PUBLISHER: The Business Research Company | PRODUCT CODE: 1712790
PUBLISHER: The Business Research Company | PRODUCT CODE: 1712790
HER2 inhibitors constitute a group of medications employed in treating HER2-low and HER2-positive breast cancers across various stages, from early to metastatic. These drugs target the HER2 receptor proteins present on breast cancer cells, hindering the reception of growth signals in HER2-positive breast cancer.
Treatments mainly consist of monotherapy and combination therapy. Monotherapy involves using a single medication for treating specific conditions or diseases. These treatments find applications in various cancer types such as squamous cell carcinoma, adenocarcinoma, large cell carcinoma, as well as breast cancer, and are utilized across healthcare sectors including hospitals, clinics, and other medical settings.
The HER2 inhibitors market research report is one of a series of new reports from The Business Research Company that provides HER2 inhibitors market statistics, including HER2 inhibitors industry global market size, regional shares, competitors with a HER2 inhibitors market share, detailed HER2 inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the HER2 inhibitors industry. This HER2 inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenarios of the industry.
The HER2 inhibitors market size has grown strongly in recent years. It will grow from $8.77 billion in 2024 to $9.64 billion in 2025 at a compound annual growth rate (CAGR) of 9.9%. The growth in the historic period can be attributed to biotechnological advances, clinical trial success, shift in treatment paradigm, research and development investments, patient outcomes improvement.
The HER2 inhibitors market size is expected to see strong growth in the next few years. It will grow to $13.61 billion in 2029 at a compound annual growth rate (CAGR) of 9.0%. The growth in the forecast period can be attributed to patient-centric care models, regulatory changes and approvals, drug resistance management, global market penetration, expanded indications, precision oncology adoption. Major trends in the forecast period include patient advocacy and awareness, clinical trials and research, early detection and diagnosis, precision medicine and biomarker testing, adjuvant and neoadjuvant therapy.
The increasing incidence of breast cancer cases worldwide is expected to be a significant factor contributing to the growth of the HER-2 inhibitors market in the forecast period. As of January 2022, the American Cancer Society reported projections of 1.9 million new cancer diagnoses and 609,360 cancer-related deaths in the United States alone. Breast cancer ranks among the four most common types of cancer globally, alongside lung, prostate, and bowel cancer, collectively accounting for 43% of all new cancer cases. Given this rise in breast cancer incidence, there is an anticipated increase in the demand for HER-2 inhibitors in the coming years.
Government initiatives aimed at enhancing breast cancer care and treatment are expected to drive the growth of the HER2 inhibitors market in the future. These initiatives include policies, funding, and programs designed to improve the accessibility, affordability, and quality of care for individuals diagnosed with breast cancer. Such government efforts have increased access to HER2 inhibitors, a treatment for breast cancer, through subsidized programs and research funding, thereby improving care and outcomes for patients. For example, in February 2023, the World Health Organization (WHO), a Switzerland-based intergovernmental organization, unveiled a new Global Breast Cancer Initiative Framework, providing a roadmap to achieve the goal of saving 2.5 million lives from breast cancer by 2040. Consequently, government initiatives to enhance breast cancer care and treatment are fueling the growth of the HER2 inhibitors market.
Prominent companies in the HER2 inhibitor market are strategically concentrating on the development of treatments for specific breast cancer subtypes to gain a competitive advantage. One such focus is on addressing HER2-low breast cancer, a newly defined subset of HER2-negative breast cancer characterized by tumors that do not overexpress or produce an excess of the HER2 protein. In August 2022, AstraZeneca PLC, a leading UK-based pharmaceutical and biotechnology company, achieved a milestone as the U.S. Food and Drug Administration (FDA) granted approval for Enhertu (fam-trastuzumab deruxtecan-nxki). Enhertu is recognized as the first HER2-directed therapy designed for patients with HER2-low metastatic breast cancer. Administered through intravenous infusion, Enhertu is prescribed for adults who have undergone prior metastatic chemotherapy or experienced disease recurrence within six months of completing adjuvant chemotherapy, targeting HER2-low (IHC 1+ or IHC 2+/ISH-) breast cancer.
Major players in the HER2 inhibitor market are directing their efforts towards developing treatments for pre-treated HR+/HER2-metastatic breast cancer. This particular breast cancer subtype, characterized by the presence of hormone receptors (HR+), is the focus of therapeutic development. In February 2023, Gilead Sciences, Inc., a prominent US-based biopharmaceutical company, received approval from the U.S. FDA for Trodelvy (sacituzumab govitecan-hziy). Trodelvy is intended for the treatment of adults with unresectable locally advanced or metastatic HR-positive, HER2-negative breast cancer. This approval is specifically granted for patients who have undergone prior endocrine-based therapies and two additional systemic treatments in the metastatic setting, addressing the needs of this particular patient population. These strategic initiatives underline the companies' commitment to developing targeted therapies for specific breast cancer subtypes, contributing to their competitive positioning in the HER2 inhibitor market.
In December 2023, Pfizer, a US-based multinational pharmaceutical and biotechnology company, acquired Seagen for around $43 billion. This acquisition is intended to strengthen Pfizer's leadership in oncology by incorporating Seagen's advanced cancer treatments and technologies. This strategic move aims to expedite the development of transformative therapies for cancer patients. Seagen is a US-based biotechnology firm that specializes in providing HER2 inhibitors.
Major companies operating in the HER2 inhibitors market include Pfizer Inc., Johnson & Johnson Services Inc., F Hoffmann-La Roche Ltd., Merck & Co. Inc., Novartis AG, Sanofi SA, Bristol-Myers Squibb Company, AstraZeneca plc, Takeda Pharmaceutical Company Limited, Eli Lilly International Corp., C.H. Boehringer Sohn AG & Co. KG, Teva Pharmaceutical Industries Ltd., Daiichi Sankyo Company Limited, Catalent Inc., Ipsen SA, the Pierre Fabre Group, Biocon Biopharmaceuticals Pvt. Ltd., Innovent Biologics Inc., Halozyme Therapeutics Inc., Seattle Genetics Inc., Zymeworks Inc., Puma Biotechnology Inc., MacroGenics Inc., Mersana Therapeutics Inc., Cellestia Biotech AG
North America was the largest region in the HER2 inhibitors market in 2024. Middle East is expected to be the fastest-growing region in the HER2 inhibitors market report during the forecast period. The regions covered in the her2 inhibitors market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the her2 inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain
The HER2 inhibitor market consists of sales of lapatinib, neratinib, tucatinib, and pyrotinib. Values in this market are ""factory gate values,"" that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
HER2 Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on her2 inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for her2 inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The her2 inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.