The global ligase market is anticipated to observe impressive growth during the forecast period, 2023-2027. The major factors include the rising prevalence of infectious, genetic, and chronic diseases and the increase in R&D activities are impelling the growth of the market. Ligases are enzymes that catalyze the reaction by joining two molecules to form a new chemical bond. Ligase has a crucial role in the molecular diagnostics method, as it makes sure the safe and effective application of targeted therapeutics. The other factors supporting the market's growth are, increasing demand for disease treatment, increasing investments in R&D, growing research & development, expansion of diagnostics and pharmaceutical companies, adoption of advanced technology, and rising world population. Also, the increasing strategic growth, such as mergers, collaborations, and acquisitions, is strengthening the growth of the market. For instance, in 2021, BLIRT S.A. enlarged its laboratory facility at Technology Park and Gdansk Science. The new laboratory is involved in growing its production scale for key enzymes and improving production processes.

Growing Need for Ligases in Disease Treatment

The surge in incidences of chronic diseases, infectious diseases, and genetic disorders across the globe is bolstering the growth of the market. The rising number of patients suffering from one of these diseases is a contributing factor. Thus, the need for better treatment to provide better patient care is fueling the growth of the market. Not only the geriatric population but the younger generation are prone to these diseases due to unhealthy choices, lifestyle changes, consumption of fast foods, and others. Thus, strengthening the growth of the market. For instance, according to WHO, every year, 17.9 million people die from cardiovascular diseases, followed by 9.3 million deaths by cancer, 4.1 million deaths from chronic respiratory diseases, and lastly, 2.0 million deaths caused by diabetes, including kidney disease. Similarly, according to the estimation of WHO, 10 out of every 1000 people are affected by genetic diseases.

Increasing R&D and Heavy Investments Fuels the Market Growth

The rise in research and development (R&D) activities across the globe to use ligase as a therapeutic intervention is propelling the growth of the market. Owing to the increase in research activities, they are used for various purposes such as mutation detection, cloning, drug targets, and others, thus, in turn, impelling the growth of the market. For instance, in March 2022, a research study named "The Role of SUMO E3 Ligases in Signaling Pathway of Cancer Cells" stated that small ubiquitin-like modifier (SUMO)ylation is a reversible post-translational modification that plays a vital role in several aspects of cell physiology, including cell cycle regulation, protein trafficking, and DNA damage repair, which are essential for cell homeostasis. Moreover, the rising investments in R&D activities for enzyme-based molecular diagnostics are facilitating the growth of the market. In 2021, Merck invested $282.5 million at its global headquarters in Darmstadt. The company is focusing on building a new translational science center for its healthcare business sector and a new learning center.

Market Segmentation

The global ligase market is segmented into product, source, application, end user, and company. Based on product, the market is segmented into quick ligase, T4 DNA ligase, E.Coli DNA ligase, T4 RNA ligase, and others. Based on the source, the market is segmented into Archaebacterium, escherichia coli, Thermus thermophilus, and others. Based on application, the market is segmented into ligase chain reaction, ligase detection reaction, next-generation sequencing, molecular cloning, and others. Based on end-user, the market is divided into biotechnology & pharmaceutical companies, academic & research institutions, and others. In terms of country, the United States is expected to be a lucrative market in the forecast period due to the rising number of research and development and clinical trial programs in the country.

Market Players

Bio-Rad Laboratories, Inc., Agilent Technologies, Inc., Codexis, Inc., F. Hoffmann-La Roche AG, Merck KGaA, Promega Corporation, QIAGEN N.V., ArcticZymes Technologies ASA, Thermo Fisher Scientific, Inc., and Takara Bio Inc. are some of the leading companies operating in the market.

Report Scope

In this report, global ligase market has been segmented into the following categories, in addition to the industry trends, which have also been detailed below:

Ligase Market, By Product:

Quick Ligase
T4 DNA Ligase
E.Coli DNA Ligase
T4 RNA Ligase
Others

Ligase Market, By Source:

Archaebacterium
Escherichia coli
Thermus thermophilus
Others

Ligase Market, By application:

Ligase Chain Reaction
Ligase Detection Reaction
Next-Generation Sequencing
Molecular Cloning
Others

Ligase Market, By End User:

Biotechnology & Pharmaceutical Companies
Academic & Research Institutions
Others

Ligase Market, By Region:

North America
- United States
- Canada
- Mexico

Asia-Pacific
- China
- India
- Japan
- Australia
- South Korea

Europe & CIS
- Germany
- France
- United Kingdom
- Spain
- Italy

South America
- Brazil
- Argentina
- Colombia

Middle East & Africa
- South Africa
- Saudi Arabia
- UAE

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in Global Ligase Market

Available Customizations

With the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report:

Company Information

Detailed analysis and profiling of additional market players (up to five).

Product Code: 13055

1. Product Overview

2. Research Methodology

3. Executive Summary

4. Impact of COVID-19 on Global Ligase Market

5. Voice of Customer

6. Global Ligase Market Outlook

6.1. Market Size & Forecast
- 6.1.1. By Value
6.2. Market Share & Forecast
- 6.2.1. By Product (Quick Ligase, T4 DNA Ligase, E.Coli DNA Ligase, T4 RNA Ligase, Others)
- 6.2.2. By Source (Archaebacterium, Escherichia coli, Thermus thermophilus, Others)
- 6.2.3. By Application (Ligase Chain Reaction, Ligase Detection Reaction, Next Generation Sequencing, Molecular Cloning, Others)
- 6.2.4. By End User (Biotechnology & Pharmaceutical Companies, Academic & Research Institutions, Others)
- 6.2.5. By Region
- 6.2.6. By Company (2021)
6.3. Market Map

7. North America Ligase Market Outlook

7.1. Market Size & Forecast
- 7.1.1. By Value
7.2. Market Share & Forecast
- 7.2.1. By Product
- 7.2.2. By Source
- 7.2.3. By Application
- 7.2.4. By End User
- 7.2.5. By Country
7.3. North America: Country Analysis
- 7.3.1. United States Ligase Market Outlook
  - 7.3.1.1. Market Size & Forecast
    - 7.3.1.1.1. By Value
  - 7.3.1.2. Market Share & Forecast
    - 7.3.1.2.1. By Product
    - 7.3.1.2.2. By Source
    - 7.3.1.2.3. By Application
    - 7.3.1.2.4. By End User
- 7.3.2. Mexico Ligase Market Outlook
  - 7.3.2.1. Market Size & Forecast
    - 7.3.2.1.1. By Value
  - 7.3.2.2. Market Share & Forecast
    - 7.3.2.2.1. By Product
    - 7.3.2.2.2. By Source
    - 7.3.2.2.3. By Application
    - 7.3.2.2.4. By End User
- 7.3.3. Canada Ligase Market Outlook
  - 7.3.3.1. Market Size & Forecast
    - 7.3.3.1.1. By Value
  - 7.3.3.2. Market Share & Forecast
    - 7.3.3.2.1. By Product
    - 7.3.3.2.2. By Source
    - 7.3.3.2.3. By Application
    - 7.3.3.2.4. By End User

8. Europe Ligase Market Outlook

8.1. Market Size & Forecast
- 8.1.1. By Value
8.2. Market Share & Forecast
- 8.2.1. By Product
- 8.2.2. By Source
- 8.2.3. By Application
- 8.2.4. By End User
- 8.2.5. By Country
8.3. Europe: Country Analysis
- 8.3.1. France Ligase Market Outlook
  - 8.3.1.1. Market Size & Forecast
    - 8.3.1.1.1. By Value
  - 8.3.1.2. Market Share & Forecast
    - 8.3.1.2.1. By Product
    - 8.3.1.2.2. By Source
    - 8.3.1.2.3. By Application
    - 8.3.1.2.4. By End User
- 8.3.2. Germany Ligase Market Outlook
  - 8.3.2.1. Market Size & Forecast
    - 8.3.2.1.1. By Value
  - 8.3.2.2. Market Share & Forecast
    - 8.3.2.2.1. By Product
    - 8.3.2.2.2. By Source
    - 8.3.2.2.3. By Application
    - 8.3.2.2.4. By End User
- 8.3.3. United Kingdom Ligase Market Outlook
  - 8.3.3.1. Market Size & Forecast
    - 8.3.3.1.1. By Value
  - 8.3.3.2. Market Share & Forecast
    - 8.3.3.2.1. By Product
    - 8.3.3.2.2. By Source
    - 8.3.3.2.3. By Application
    - 8.3.3.2.4. By End User
- 8.3.4. Italy Ligase Market Outlook
  - 8.3.4.1. Market Size & Forecast
    - 8.3.4.1.1. By Value
  - 8.3.4.2. Market Share & Forecast
    - 8.3.4.2.1. By Product
    - 8.3.4.2.2. By Source
    - 8.3.4.2.3. By Application
    - 8.3.4.2.4. By End User
- 8.3.5. Spain Ligase Market Outlook
  - 8.3.5.1. Market Size & Forecast
    - 8.3.5.1.1. By Value
  - 8.3.5.2. Market Share & Forecast
    - 8.3.5.2.1. By Product
    - 8.3.5.2.2. By Source
    - 8.3.5.2.3. By Application
    - 8.3.5.2.4. By End User

9. Asia-Pacific Ligase Market Outlook

9.1. Market Size & Forecast
- 9.1.1. By Value
9.2. Market Share & Forecast
- 9.2.1. By Product
- 9.2.2. By Source
- 9.2.3. By Application
- 9.2.4. By End User
- 9.2.5. By Country
9.3. Asia-Pacific: Country Analysis
- 9.3.1. China Ligase Market Outlook
  - 9.3.1.1. Market Size & Forecast
    - 9.3.1.1.1. By Value
  - 9.3.1.2. Market Share & Forecast
    - 9.3.1.2.1. By Product
    - 9.3.1.2.2. By Source
    - 9.3.1.2.3. By Application
    - 9.3.1.2.4. By End User
- 9.3.2. India Ligase Market Outlook
  - 9.3.2.1. Market Size & Forecast
    - 9.3.2.1.1. By Value
  - 9.3.2.2. Market Share & Forecast
    - 9.3.2.2.1. By Product
    - 9.3.2.2.2. By Source
    - 9.3.2.2.3. By Application
    - 9.3.2.2.4. By End User
- 9.3.3. Japan Ligase Market Outlook
  - 9.3.3.1. Market Size & Forecast
    - 9.3.3.1.1. By Value
  - 9.3.3.2. Market Share & Forecast
    - 9.3.3.2.1. By Product
    - 9.3.3.2.2. By Source
    - 9.3.3.2.3. By Application
    - 9.3.3.2.4. By End User
- 9.3.4. South Korea Ligase Market Outlook
  - 9.3.4.1. Market Size & Forecast
    - 9.3.4.1.1. By Value
  - 9.3.4.2. Market Share & Forecast
    - 9.3.4.2.1. By Product
    - 9.3.4.2.2. By Source
    - 9.3.4.2.3. By Application
    - 9.3.4.2.4. By End User
- 9.3.5. Australia Ligase Market Outlook
  - 9.3.5.1. Market Size & Forecast
    - 9.3.5.1.1. By Value
  - 9.3.5.2. Market Share & Forecast
    - 9.3.5.2.1. By Product
    - 9.3.5.2.2. By Source
    - 9.3.5.2.3. By Application
    - 9.3.5.2.4. By End User

10. South America Ligase Market Outlook

10.1. Market Size & Forecast
- 10.1.1. By Value
10.2. Market Share & Forecast
- 10.2.1. By Product
- 10.2.2. By Source
- 10.2.3. By Application
- 10.2.4. By End User
- 10.2.5. By Country
10.3. South America: Country Analysis
- 10.3.1. Brazil Ligase Market Outlook
  - 10.3.1.1. Market Size & Forecast
    - 10.3.1.1.1. By Value
  - 10.3.1.2. Market Share & Forecast
    - 10.3.1.2.1. By Product
    - 10.3.1.2.2. By Source
    - 10.3.1.2.3. By Application
    - 10.3.1.2.4. By End User
- 10.3.2. Argentina Ligase Market Outlook
  - 10.3.2.1. Market Size & Forecast
    - 10.3.2.1.1. By Value
  - 10.3.2.2. Market Share & Forecast
    - 10.3.2.2.1. By Product
    - 10.3.2.2.2. By Source
    - 10.3.2.2.3. By Application
    - 10.3.2.2.4. By End User
- 10.3.3. Colombia Ligase Market Outlook
  - 10.3.3.1. Market Size & Forecast
    - 10.3.3.1.1. By Value
  - 10.3.3.2. Market Share & Forecast
    - 10.3.3.2.1. By Product
    - 10.3.3.2.2. By Source
    - 10.3.3.2.3. By Application
    - 10.3.3.2.4. By End User

11. Middle East and Africa Ligase Market Outlook

11.1. Market Size & Forecast
- 11.1.1. By Value
11.2. Market Share & Forecast
- 11.2.1. By Product
- 11.2.2. By Source
- 11.2.3. By Application
- 11.2.4. By End User
- 11.2.5. By Country
11.3. MEA: Country Analysis
- 11.3.1. South Africa Ligase Market Outlook
  - 11.3.1.1. Market Size & Forecast
    - 11.3.1.1.1. By Value
  - 11.3.1.2. Market Share & Forecast
    - 11.3.1.2.1. By Product
    - 11.3.1.2.2. By Source
    - 11.3.1.2.3. By Application
    - 11.3.1.2.4. By End User
- 11.3.2. Saudi Arabia Ligase Market Outlook
  - 11.3.2.1. Market Size & Forecast
    - 11.3.2.1.1. By Value
  - 11.3.2.2. Market Share & Forecast
    - 11.3.2.2.1. By Product
    - 11.3.2.2.2. By Source
    - 11.3.2.2.3. By Application
    - 11.3.2.2.4. By End User
- 11.3.3. UAE Ligase Market Outlook
  - 11.3.3.1. Market Size & Forecast
    - 11.3.3.1.1. By Value
  - 11.3.3.2. Market Share & Forecast
    - 11.3.3.2.1. By Product
    - 11.3.3.2.2. By Source
    - 11.3.3.2.3. By Application
    - 11.3.3.2.4. By End User

12. Market Dynamics

12.1. Drivers
12.2. Challenges

13. Market Trends & Developments

14. Competitive Landscape

14.1. Bio-Rad Laboratories, Inc.
14.2. Agilent Technologies, Inc.
14.3. Codexis, Inc.
14.4. F. Hoffmann-La Roche AG
14.5. Merck KGaA
14.6. Promega Corporation
14.7. QIAGEN N.V.
14.8. ArcticZymes Technologies ASA
14.9. Thermo Fisher Scientific, Inc.
14.10. Takara Bio Inc.

15. Strategic Recommendations

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