PUBLISHER: The Insight Partners | PRODUCT CODE: 1498570
PUBLISHER: The Insight Partners | PRODUCT CODE: 1498570
North America Cardiac Markers Market Size and Forecast, Regional Share, Trend, and Growth Opportunity Analysis Report Coverage: By Product Type, Biomarker Type, Indication, End User, and Country
The global North America cardiac marker market is expected to reach US$ 2.87 billion by 2031 from US$ 1.17 billion in 2023. The market is estimated to grow with a CAGR of 11.8% from 2023 to 2031.
The North America cardiac marker market forecast presented in this report can help stakeholders in this marketplace plan their growth strategies. The rising prevalence of cardiovascular diseases and a surge in the demand for point-of-care cardiac testing kits are the key factors propelling the North America cardiac marker market growth.
Ongoing Research in Use of Exosomes as CVD Biomarkers
Hypoxia significantly affects exosome cargo and produces various proteins and miRNAs that indicate angiogenesis, growth, and progression for CVD through different signaling pathways. Exosomes has gathered the attention of researchers because they are relevant to intercellular communication under both physiological and pathological conditions. The upregulated exosome miRNAs miR-133a, miR-208a, miR-1, miR-499-5p, and miR-30a have been designated for the timely diagnosis of acute myocardial infarction (AMI). Further, derived exosomes namely, miR-192, miR-146a, miR-194, and miR-92b-5p are considered as potential biomarkers for HF.
- Table 1. Exosomes as CVD Biomarkers
Biomarker Disease Function
miRNA-126, miRNA-223, and miRNA-320b Acute myocardial infarction Platelet activation and thrombus formation, endothelial damage, myocardial apoptosis, and fibroblast proliferation
miRNA-1, miRNA-21a/b, and miRNA-29b Acute myocardial infraction Myocardial apoptosis, fibroblast proliferation, and cardiac hypertrophy
miRNA-208a Acute myocardial infarction Cardiac hypertrophy and electrical conduction
miRNA-499 Acute myocardial infarction Myocardial apoptosis
miRNA-486 Acute myocardial infarction Myocardial apoptosis (protective)
miRNA-223-5p Acute myocardial infarction, atherosclerosis, and heart failure Cell proliferation, migration, apoptosis, and polarization; cardiomyocyte hypertrophy; and electrical conduction
miRNA-941 Acute coronary syndrome Cell proliferation and inflammation
miRNA-216a and miRNA-451 Coronary artery disease Endothelial damage and monocyte recruitment
miRNA-223-3p, miRNA-122-5p, and miRNA-93-5p Coronary artery disease Inflammation, migration and apoptosis, cardiomyocyte hypertrophy, electrical conduction, and cardiomyocyte apoptosis
miRNA-142-3p, miRNA-17-5p, and miRNA-126 Acute myocardial infarction and coronary artery disease Inflammation; cardiomyocyte hypertrophy; and cell proliferation, migration, and apoptosis
miRNA-133a Coronary artery disease Cell proliferation and differentiation, cardiac hypertrophy, and electrical conduction (arrhythmia)
Serpin G1, Serpin F2, and Cystatin C CD14 Heart failure and acute coronary syndrome Inflammation, decrease in kidney function, decrease in fibrinolysis, and thrombotic process
Source: Allen Press
In coronary artery disease (CAD) patients, upregulated exosome proteins-including fibrinogen beta/gamma chain, alpha-1-antichymotrypsin, and inter-alpha-trypsin inhibitor heavy chain-were evaluated as putative protein biomarkers. The function of exosomes in CVD pathogenesis through diverse intercellular communication mechanisms is gaining significant recognition. Several studies conducted in recent years have generated evidence supporting the association of exosomes with normal physiology (cardiac development, reticulocyte maturation, and myocardial angiogenesis) and pathophysiological processes, including ischemia/reperfusion (IR) injury, atherosclerosis, and cardiac remodeling. Stressful conditions such as hypoxia and inflammation can modulate biological exosome content and target cells, thereby contributing to improving or impairing cardiac function. The integration of exosome-based miRNAs and proteins in body fluids enables a comprehensive analysis of the potential biomarker role of these components in cardiovascular diseases. Therefore, the use of exosome biomarkers is emerging as a new approach for the diagnosis of CVDs.
Factor Hampering North American Cardiac Marker Market
Companies can submit an application for regulatory qualification for a cardiac marker to the FDA Biomarker Qualification Program for a specific application. Only the qualified marker can be used in multiple drug development programs without the need for the Center for Drug Evaluation and Research (CDER) approval to reconfirm the suitability of the markers.
Cardiac markers are widely used in epidemiological studies for completing the investigation of numerous stages of CVD. The process requires more careful handling and storage of valuable biological samples to obtain detailed information. Precise quality control measures are required to ensure that these samples are handled in appropriate storage conditions to avoid data loss. Cardiac marker studies depend on the integrity of samples and the manner of collection, processing, and storage, as archived samples are used in these studies. Handling, labeling, processing, aliquoting, storage, and transportation may affect study results. The sample must be placed on dry ice and shipped the same day. If the process is not carried out properly, it can impact the quality of the sample, subsequently hampering the outcomes. Therefore, strict validation protocols established by the US FDA and technical issues associated with sample collection and storage hamper the growth of the North America cardiac markers market.
Based on disease, the North America cardiac marker market is divided into HIV testing, influenza testing, sexually transmitted diseases testing, hepatitis C virus testing, tropical diseases testing, respiratory infection testing, hospital-acquired infections, strep, and others. The market is further divided on the basis of molecular diagnostics into polymerase chain reactions (PCR), isothermal nucleic acid amplification technology (INAAT), and others. The respiratory infection testing segment held the largest market share in 2023.
Based on product type, the North America cardiac markers market is segmented into reagents and kits, and analyzers. The analyzers segment held a larger share in 2023. The reagents and kits segment is expected to register a higher CAGR during 2023-2031.
Based on biomarker type, the North America cardiac markers market is divided into troponin, creatine kinase-MB, myoglobin, B-type natriuretic peptide, and others. The troponin segment held the largest market share in 2023 and is estimated to register the highest CAGR in the market during 2023-2031.
By indication, the market is segmented into congestive heart failure, myocardial infraction, acute coronary syndrome, and others. The congestive heart failure segment held the largest share of the market in 2023. The acute coronary syndrome segment is estimated to register the highest CAGR during 2023-2031.
In terms of end user, the North America cardiac markers market is divided into hospitals, diagnostic laboratories, point-of-care testing facilities, and others. The hospitals segment held the largest market share in 2023. The diagnostic laboratories segment is estimated to register the highest CAGR in the market during 2023-2031.
North America Point-Of-Care Molecular Testing for Infectious Diseases Market: Regional Overview
The the developed healthcare system and the high acceptance of cardiac markers for diagnosing and predicting diseases. The growing geriatric population needs biomarker testing for detecting conditions such as acute myocardial infarction, thereby driving demand for testing products. The existence of key players such as Quidel Corporation and Danaher Corporation in the region is another factor contributing to the growth of this market. According to the World Health Organization (WHO), ~77 million adults over the age of 18 have type 2 diabetes, including 25 million prediabetes, which increases the possibility of cardiovascular diseases (CVDs) and puts additional pressure on the healthcare system. Furthermore, increasing strategies adopted by market players in this region to develop innovative cardiac biomarker tests are expected to contribute to the market growth in this region.
A few of the major primary and secondary sources referred to while preparing the report on the North America cardiac marker market are the World Bank Data, National Health Service (NHS), US Department of Health and Human Services (HHS), and WHO (World Health Organization).
Table Of Contents
1. Introduction
- 1.1 The Insight Partners Research Report Guidance
- 1.2 Market Segmentation
2. Executive Summary
- 2.1 Key Insights
3. Research Methodology
- 3.1 Secondary Research
- 3.2 Primary Research
- 3.2.1 Hypothesis formulation:
- 3.2.2 Macro-economic factor analysis:
- 3.2.3 Developing base number:
- 3.2.4 Data Triangulation:
- 3.2.5 Country level data:
4. North America Cardiac Marker Market Landscape
- 4.1 Overview
- 4.2 PEST Analysis
5. North America Cardiac Marker Market - Key Market Dynamics
- 5.1 North America Cardiac Marker Market - Key Market Dynamics
- 5.2 Market Drivers
- 5.2.1 Rising Prevalence of Cardiovascular Diseases
- 5.2.2 Surge in Demand for Point-of-Care Cardiac Testing Kits
- 5.3 Market Restraints
- 5.3.1 Strict Validation and Technical Issues Related to Sample Collection and Storage
- 5.4 Market Opportunities
- 5.4.1 Investments in Cardiovascular Sector
- 5.5 Future Trends
- 5.5.1 Ongoing Research in Use of Exosomes as CVD Biomarkers
- 5.6 Impact analysis
6. North America Cardiac Marker Market Analysis
- 6.1 North America Cardiac Marker Market Revenue (US$ Million), 2021-2031
7. North America Cardiac Marker Market Analysis - by Product Type
- 7.1 Analyzers
- 7.1.1 Overview
- 7.1.2 Analyzers: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 7.2 Reagents and Kits
- 7.2.1 Overview
- 7.2.2 Reagents and Kits: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
8. North America Cardiac Marker Market Analysis - by Biomarker Type
- 8.1 Troponin
- 8.1.1 Overview
- 8.1.2 Troponin: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 8.2 Creatine Kinase-MB
- 8.2.1 Overview
- 8.2.2 Creatine Kinase-MB: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 8.3 Myoglobin
- 8.3.1 Overview
- 8.3.2 Myoglobin: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 8.4 B-Type Natriuretic Peptide
- 8.4.1 Overview
- 8.4.2 B-Type Natriuretic Peptide: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 8.5 Others
- 8.5.1 Overview
- 8.5.2 Others: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
9. North America Cardiac Marker Market Analysis - by Indication
- 9.1 Congestive Heart Failure
- 9.1.1 Overview
- 9.1.2 Congestive Heart Failure: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 9.2 Myocardial Infraction
- 9.2.1 Overview
- 9.2.2 Myocardial Infraction: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 9.3 Acute Coronary Syndrome
- 9.3.1 Overview
- 9.3.2 Acute Coronary Syndrome: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 9.4 Others
- 9.4.1 Overview
- 9.4.2 Others: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
10. North America Cardiac Marker Market Analysis - by End User
- 10.1 Hospitals
- 10.1.1 Overview
- 10.1.2 Hospitals: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 10.2 Diagnostic Laboratories
- 10.2.1 Overview
- 10.2.2 Diagnostic Laboratories: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 10.3 Point-of-Care Testing Facilities
- 10.3.1 Overview
- 10.3.2 Point-of-Care Testing Facilities: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 10.4 Others
- 10.4.1 Overview
- 10.4.2 Others: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
11. North America Cardiac Marker Market - Country Analysis
- 11.1 North America
- 11.1.1 North America Cardiac Marker Market Breakdown by Countries
- 11.1.2 North America Cardiac Marker Market Revenue and Forecast and Analysis - by Country
- 11.1.2.1 United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 11.1.2.1.1 United States: North America Cardiac Marker Market Breakdown by Product Type
- 11.1.2.1.2 United States: North America Cardiac Marker Market Breakdown by Biomarker Type
- 11.1.2.1.3 United States: North America Cardiac Marker Market Breakdown by Indication
- 11.1.2.1.4 United States: North America Cardiac Marker Market Breakdown by End User
- 11.1.2.2 Canada: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 11.1.2.2.1 Canada: North America Cardiac Marker Market Breakdown by Product Type
- 11.1.2.2.2 Canada: North America Cardiac Marker Market Breakdown by Biomarker Type
- 11.1.2.2.3 Canada: North America Cardiac Marker Market Breakdown by Indication
- 11.1.2.2.4 Canada: North America Cardiac Marker Market Breakdown by End User
- 11.1.2.3 Mexico: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- 11.1.2.3.1 Mexico: North America Cardiac Marker Market Breakdown by Product Type
- 11.1.2.3.2 Mexico: North America Cardiac Marker Market Breakdown by Biomarker Type
- 11.1.2.3.3 Mexico: North America Cardiac Marker Market Breakdown by Indication
- 11.1.2.3.4 Mexico: North America Cardiac Marker Market Breakdown by End User
- 11.1.2.1 United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
12. Industry Landscape
- 12.1 Overview
- 12.2 Recent Development Strategies
- 12.2.1 Overview
13. Cardiac Marker Market-Industry Landscape
- 13.1 Overview
- 13.2 Organic Growth Strategies
- 13.2.1 Overview
14. Company Profiles
- 14.1 Abbott Laboratories
- 14.1.1 Key Facts
- 14.1.2 Business Description
- 14.1.3 Products and Services
- 14.1.4 Financial Overview
- 14.1.5 SWOT Analysis
- 14.1.6 Key Developments
- 14.2 F. Hoffmann-La Roche Ltd
- 14.2.1 Key Facts
- 14.2.2 Business Description
- 14.2.3 Products and Services
- 14.2.4 Financial Overview
- 14.2.5 SWOT Analysis
- 14.2.6 Key Developments
- 14.3 Thermo Fisher Scientific Inc
- 14.3.1 Key Facts
- 14.3.2 Business Description
- 14.3.3 Products and Services
- 14.3.4 Financial Overview
- 14.3.5 SWOT Analysis
- 14.3.6 Key Developments
- 14.4 Beckman Coulter Inc
- 14.4.1 Key Facts
- 14.4.2 Business Description
- 14.4.3 Products and Services
- 14.4.4 Financial Overview
- 14.4.5 SWOT Analysis
- 14.4.6 Key Developments
- 14.5 Bio-Rad Laboratories Inc
- 14.5.1 Key Facts
- 14.5.2 Business Description
- 14.5.3 Products and Services
- 14.5.4 Financial Overview
- 14.5.5 SWOT Analysis
- 14.5.6 Key Developments
- 14.6 Creative Diagnostics
- 14.6.1 Key Facts
- 14.6.2 Business Description
- 14.6.3 Products and Services
- 14.6.4 Financial Overview
- 14.6.5 SWOT Analysis
- 14.6.6 Key Developments
- 14.7 Diazyme Laboratories, Inc.
- 14.7.1 Key Facts
- 14.7.2 Business Description
- 14.7.3 Products and Services
- 14.7.4 Financial Overview
- 14.7.5 SWOT Analysis
- 14.7.6 Key Developments
- 14.8 bioMerieux SA
- 14.8.1 Key Facts
- 14.8.2 Business Description
- 14.8.3 Products and Services
- 14.8.4 Financial Overview
- 14.8.5 SWOT Analysis
- 14.8.6 Key Developments
- 14.9 HyTest Ltd.
- 14.9.1 Key Facts
- 14.9.2 Business Description
- 14.9.3 Products and Services
- 14.9.4 Financial Overview
- 14.9.5 SWOT Analysis
- 14.9.6 Key Developments
- 14.10 QuidelOrtho Corp
- 14.10.1 Key Facts
- 14.10.2 Business Description
- 14.10.3 Products and Services
- 14.10.4 Financial Overview
- 14.10.5 SWOT Analysis
- 14.10.6 Key Developments
15. Appendix
- 15.1 About The Insight Partners
- 15.2 Glossary of Terms
List Of Tables
- Table 1. North America Cardiac Marker Market Segmentation
- Table 2. Available POC Products in the US
- Table 3. Exosomes as CVD Biomarkers
- Table 4. United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Product Type
- Table 5. United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Biomarker Type
- Table 6. United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Indication
- Table 7. United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by End User
- Table 8. Canada: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Product Type
- Table 9. Canada: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Biomarker Type
- Table 10. Canada: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Indication
- Table 11. Canada: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by End User
- Table 12. Mexico: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Product Type
- Table 13. Mexico: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Biomarker Type
- Table 14. Mexico: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by Indication
- Table 15. Mexico: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million) - by End User
- Table 16. Recent Development Activities in the Cardiac Marker Market
- Table 17. Recent Organic Growth Strategies in the Cardiac Marker Market
- Table 18. Glossary of Terms, North America Cardiac Marker Market
List Of Figures
- Figure 1. North America Cardiac Marker Market Segmentation, by Country
- Figure 2. PEST Analysis
- Figure 3. Impact Analysis of Drivers and Restraints
- Figure 4. North America Cardiac Marker Market Revenue (US$ Million), 2021-2031
- Figure 5. North America Cardiac Marker Market Share (%) - by Product Type, 2023 and 2031
- Figure 6. Analyzers: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 7. Reagents and Kits: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 8. North America Cardiac Marker Market Share (%) - by Biomarker Type, 2023 and 2031
- Figure 9. Troponin: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 10. Creatine Kinase-MB: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 11. Myoglobin: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 12. B-Type Natriuretic Peptide: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 13. Others: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 14. North America Cardiac Marker Market Share (%) - by Indication, 2023 and 2031
- Figure 15. Congestive Heart Failure: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 16. Myocardial Infraction: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 17. Acute Coronary Syndrome: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 18. Others: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 19. North America Cardiac Marker Market Share (%) - by End User, 2023 and 2031
- Figure 20. Hospitals: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 21. Diagnostic Laboratories: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 22. Point-of-Care Testing Facilities: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 23. Others: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 24. North America Cardiac Marker Market Breakdown by Key Countries, 2023 and 2031 (%)
- Figure 25. United States: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 26. Canada: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
- Figure 27. Mexico: North America Cardiac Marker Market - Revenue and Forecast to 2031 (US$ Million)
