PUBLISHER: The Business Research Company | PRODUCT CODE: 1670873
PUBLISHER: The Business Research Company | PRODUCT CODE: 1670873
Proteasome inhibitors constitute a class of drugs designed to disrupt the activity of proteasomes, cellular complexes responsible for the regulated degradation of proteins. These inhibitors find primary application in the treatment of specific types of cancer, particularly multiple myeloma, and certain forms of lymphoma. They have demonstrated significant efficacy in targeting cancer cells and inducing cell death.
The main types of products in proteasome inhibitors include Velcade, Kyprolis, Ninlaro, and others. Velcade, for instance, is the brand name for the prescription drug bortezomib. Bortezomib, as a proteasome inhibitor, is utilized in the treatment of multiple myeloma cancer. Various drugs fall under this category, such as bortezomib, carfilzomib, and ixazomib. Proteasome inhibitors are employed to treat diverse indications, including lymphoma, mantle cell lymphoma, and multiple myeloma. These drugs are distributed through hospital pharmacies, online pharmacies, and retail pharmacies, with end-users primarily consisting of hospitals, specialty clinics, and others.
The proteasome inhibitors market research report is one of a series of new reports from The Business Research Company that provides proteasome inhibitors market statistics, including proteasome inhibitors industry global market size, regional shares, competitors with a proteasome inhibitors market share, detailed proteasome inhibitors market segments, market trends and opportunities, and any further data you may need to thrive in the proteasome inhibitors industry. This proteasome inhibitors market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The proteasome inhibitors market size has grown strongly in recent years. It will grow from $2.01 billion in 2024 to $2.19 billion in 2025 at a compound annual growth rate (CAGR) of 9.0%. The growth in the historic period can be attributed to scientific breakthroughs, clinical research and trials, FDA approvals, rising cancer cases, advancements in drug delivery
The proteasome inhibitors market size is expected to see strong growth in the next few years. It will grow to $3.2 billion in 2029 at a compound annual growth rate (CAGR) of 9.9%. The growth in the forecast period can be attributed to precision medicine approaches, next-generation inhibitors, healthcare infrastructure growth, targeted therapies combination, emerging markets adoption. Major trends in the forecast period include immunotherapy combinations, selective proteasome inhibition, longer half-life inhibitors, oral formulations, resistant cancer variant treatments.
The growing prevalence of pancreatic cancer is anticipated to drive the expansion of the proteasome inhibitors market in the future. Pancreatic cancer occurs when cancer develops in the cells of the pancreas, an organ situated in the abdomen behind the stomach. Proteasome inhibitors are primarily utilized in the treatment of pancreatic cancer, as the proteasome plays a vital role in promoting cell survival and growth by degrading proteins that regulate cell cycle progression and apoptosis. By disrupting cancer cell survival, these inhibitors hinder tumor growth and metastasis. For instance, in January 2024, reports from the American Cancer Society, a US-based health organization, indicated that approximately 64,050 adults in the US were diagnosed with pancreatic cancer in 2023, resulting in 50,550 deaths. Additionally, this number is projected to rise to 66,440 diagnosed cases, with deaths increasing to 51,750. Therefore, the rising prevalence of pancreatic cancer is propelling the growth of the proteasome inhibitors market.
The growth of the proteasome inhibitors market is further propelled by increasing government funding for research and development. Government funding plays a crucial role in advancing proteasome inhibitor research by financially supporting scientific investigations, clinical trials, and drug development. For example, the National Cancer Institute in the US received a budget of $7.3 billion in fiscal year 2023, a $408 million increase over 2022. This substantial funding boost contributes to driving the growth of the proteasome inhibitors market.
Investments are emerging as a key trend in the proteasome inhibitors market, with major companies investing in the development and commercialization of these inhibitors. In September 2022, QLi5 Therapeutics GmbH, a Germany-based developer of novel proteasome inhibitors, secured a significant investment of $10.96 million from venture capital firms such as SV Investment, KHAN Technology Transfer Fund I, Atinum Investment Co., Ltd., and Daol Investment & Securities Co., Ltd. This funding supports QLi5's efforts to advance its pipeline of distinct proteasome inhibitors for cancer, inflammatory, and autoimmune disorders, contributing to the market's growth.
Major companies in the proteasome inhibitor market are intensifying their efforts to develop novel generic medications, such as single-dose vials, to secure a competitive advantage. A single-dose vial is a sealed container, usually made of glass, that holds a single dose of medication intended for parenteral administration, which means it is delivered through injection or infusion. For example, in July 2022, Dr. Reddy's Laboratories, a pharmaceutical company based in India, launched Bortezomib for Injection, 3.5 mg, in the U.S. market. This product serves as the generic equivalent of Velcade (bortezomib) injection, having received approval from the U.S. Food and Drug Administration (USFDA). Bortezomib is indicated for adult patients diagnosed with multiple myeloma and is available in a 3.5 mg per 10 mL single-dose vial format for subcutaneous (SQ) or intravenous (IV) administration.
In October 2022, Karyopharm Therapeutics Inc., a US-based pharmaceutical company, collaborated with Bristol-Myers Squibb to assess mezigdomide in patients who have received previous treatments. This collaboration with Bristol-Myers Squibb, a provider of innovative medicines, demonstrates a strategic approach to advancing research and development in the proteasome inhibitors market.
Major companies operating in the proteasome inhibitors market include Pfizer Inc., Johnson And Johnson, AbbVie, Novartis AG, Merck & Co. Inc., Bristol-Myers Squibb Company, Thermo Fisher Scientific Inc., AstraZeneca Plc, Fresenius Kabi AG, GlaxoSmithKline PLC, Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Amgen Inc., Baxter International Inc., Sigma-Aldrich, Zydus Pharmaceuticals, Onyx Pharmaceuticals Inc., Tocris Bioscience, Accuitis Inc., TG Therapeuticsn Inc., QLi5 Therapeutics GmbH, Progenra Inc., Nurix Inc., Cephalon Inc., Cleave Therapeutics, Lifesensors Inc., MimiVax LLC, Apotex Inc.
North America was the largest region in the proteasome inhibitors market in 2024. The regions covered in the proteasome inhibitors market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
The countries covered in the proteasome inhibitors market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The proteasome inhibitor market consists of sales of marizomib, oprozomib, and delanzomib, epoxyketone proteasome inhibitors, non-peptidic proteasome inhibitors, panobinostat and olaparib. Values in this market are 'factory gate' values, that is, the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Proteasome Inhibitors Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on proteasome inhibitors market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for proteasome inhibitors ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The proteasome inhibitors market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.