PUBLISHER: The Business Research Company | PRODUCT CODE: 1664772
PUBLISHER: The Business Research Company | PRODUCT CODE: 1664772
Tumor infiltrating lymphocytes (TILs) are immune cells capable of identifying and eliminating cancer cells upon entering a tumor through the bloodstream. They are extracted from a patient's tumor, expanded in large quantities within a laboratory setting, and subsequently reintroduced into the patient's body to assist the immune system in targeting and destroying cancer cells.
Key components or anatomies of tumor-infiltrating lymphocytes encompass CD3, CD8, CD16, CD56, CD4, CD57, CD169, CD68, and FOXP3. CD3, also known as the cluster of differentiation 3, constitutes a complex protein structure involving T-cells, B-cells, and natural killer cells. These components find applications in various cancers such as melanoma, cervical cancer, ovarian cancer, among others. The end-users of these lymphocytes include hospitals, cancer research centers, and clinics involved in cancer treatment and research.
The tumor infiltrating lymphocytes market research report is one of a series of new reports from. The Business Research Company that provides tumor infiltrating lymphocytes market statistics, including tumor infiltrating lymphocytes industry global market size, regional shares, competitors with a tumor infiltrating lymphocytes market share, detailed tumor infiltrating lymphocytes market segments, market trends and opportunities, and any further data you may need to thrive in the tumor infiltrating lymphocytes industry. This tumor infiltrating lymphocytes market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.
The tumor infiltrating lymphocytes market size has grown rapidly in recent years. It will grow from $10.6 billion in 2024 to $12.15 billion in 2025 at a compound annual growth rate (CAGR) of 14.6%. The growth in the historic period can be attributed to increasing cancer incidence, research funding, regulatory approvals, growing awareness, clinical success and efficacy.
The tumor infiltrating lymphocytes market size is expected to see rapid growth in the next few years. It will grow to $20.85 billion in 2029 at a compound annual growth rate (CAGR) of 14.5%. The growth in the forecast period can be attributed to pipeline developments, increasing healthcare expenditure, emerging markets, strategic alliances, regulatory support, patient demand. Major trends in the forecast period include advancements in immunotherapy, research and development initiatives, regulatory landscape, personalized medicine, market competition.
The increasing prevalence of cancer patients is expected to drive the growth of the tumor-infiltrating lymphocytes (TIL) market in the future. Cancer is a condition characterized by the uncontrolled growth of certain cells in the body, which can spread to other areas and cause various health complications, some of which may be life-threatening. Tumor-infiltrating lymphocytes are a type of immune cell capable of identifying and eliminating cancer cells. These lymphocytes are extracted from a patient's tumor, cultivated in large quantities in a laboratory, and then reintroduced into the patient to aid the immune system in attacking the cancer cells. For example, in August 2024, a report from the Australian Institute of Health and Welfare, a national agency for health and welfare statistics in Australia, indicated that by 2034, the country is expected to see around 209,000 new cancer diagnoses, a substantial increase from the estimated 169,000 cases projected for 2024, highlighting the effects of a growing population and increasing cancer rates. Furthermore, in 2024, cancer is predicted to account for roughly 3 out of every 10 deaths in Australia. Therefore, the rise in cancer patients is set to propel the growth of the tumor-infiltrating lymphocyte market.
The growing demand from patients for personalized therapies is poised to fuel the growth of the tumor-infiltrating lymphocyte market in the foreseeable future. Personalized therapies involve tailoring medical treatments to an individual's distinct characteristics, including genetic makeup, molecular traits, lifestyle, and environmental influences. The incorporation of tumor-infiltrating lymphocytes in customized treatments aims to enhance cancer treatment strategies by leveraging the unique immune profiles of each patient. In February 2023, the Personalized Medicine Coalition reported that personalized medications constituted 34% of new drug approvals by the US Food and Drug Administration in 2022, contributing to at least 25% of approvals in each of the preceding eight years. The increasing patient demand for personalized therapies emerges as a key driver propelling the growth of the tumor-infiltrating lymphocyte market.
Technological advancements emerge as a prominent trend gaining traction in the tumor-infiltrating lymphocytes market, with major companies strategically focusing on developing cutting-edge solutions to enhance their market positions. An illustrative example is Obsidian Therapeutics Inc., a US-based biotechnology firm specializing in engineered tumor-infiltrating lymphocytes (TIL cells) and gene treatments. In May 2022, Obsidian Therapeutics announced the introduction of cytoDRIVE technology, showcasing its ability to precisely regulate the time and level of protein activity using FDA-approved small chemicals. This technological innovation holds significant potential for treating solid cancers by employing potent cytokines such as IL12 to support cell treatments. The study revealed that various cytokines, including IL12, IL23, IL2, and IFN, could be robustly and reversibly regulated, potentially enabling their safe utilization in adoptive cell therapy applications.
Leading companies in the tumor-infiltrating lymphocyte market are pursuing a strategic partnership approach to create innovative treatments focused on gene editing. Strategic partnerships involve companies leveraging each other's strengths and resources for mutual benefit and success. For example, in February 2023, Moderna, a US-based pharmaceutical and biotechnology firm, formed a strategic collaboration with Life Edit Therapeutics, a US-based next-generation genome editing company, to expedite the development of new in vivo gene editing therapies. This partnership intends to utilize Moderna's mRNA technology in conjunction with Life Edit's proprietary genome editing platform to develop more effective and precise treatments for various conditions, including cancer and genetic disorders. This collaboration exemplifies a rising trend in the biopharmaceutical sector to integrate innovative technologies for advanced therapeutic solutions.
In May 2023, Phio Pharmaceuticals, a US-based biotechnology company, teamed up with AgonOx Inc. to enhance the development of innovative tumor-infiltrating lymphocyte (TIL) therapies for cancer patients. This partnership aims to leverage Phio's proprietary technology in engineered TILs alongside AgonOx's expertise in immuno-oncology, potentially leading to improved treatment options for patients with solid tumors. AgonOx Inc. is a US-based company focused on developing novel therapies for cancer patients.
Major companies operating in the tumor infiltrating lymphocytes market include Novartis AG, Pfizer Inc., Precision BioScience Inc., TCR2 Therapeutics Inc., Merck KGaA, Autolus Therapeutics PLC., Eli Lilly and Company, Oxford Biomedica PLC., Unum Therapeutics Inc., Amgen Inc., Gilead Sciences Inc., Sorrento Therapeutics Inc., TILT Biotherapeutics Ltd., Iovance Biotherapeutics Inc., Adaptimmune Therapeutics plc, Atara Biotherapeutics Inc., BioNTech SE, CARsgen Therapeutics Ltd., Cellectis S.A., Celyad Oncology SA, CRISPR Therapeutics AG, Intellia Therapeutics Inc., MaxCyte Inc.
North America was the largest region in the tumor infiltrating lymphocytes market in 2024. The regions covered in the tumor infiltrating lymphocytes market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa
The countries covered in the tumor infiltrating lymphocytes market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Russia, South Korea, UK, USA, Canada, Italy, Spain.
The tumor infiltrating lymphocytes market consists of sales of autologous TILs (tumor infiltrating lymphocytes), allogeneic TILs, and engineered TILs. Values in this market are 'factory gate' values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors, and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.
The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD, unless otherwise specified).
The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.
Tumor Infiltrating Lymphocytes Global Market Report 2025 from The Business Research Company provides strategists, marketers and senior management with the critical information they need to assess the market.
This report focuses on tumor infiltrating lymphocytes market which is experiencing strong growth. The report gives a guide to the trends which will be shaping the market over the next ten years and beyond.
Where is the largest and fastest growing market for tumor infiltrating lymphocytes ? How does the market relate to the overall economy, demography and other similar markets? What forces will shape the market going forward? The tumor infiltrating lymphocytes market global report from the Business Research Company answers all these questions and many more.
The report covers market characteristics, size and growth, segmentation, regional and country breakdowns, competitive landscape, market shares, trends and strategies for this market. It traces the market's historic and forecast market growth by geography.
The forecasts are made after considering the major factors currently impacting the market. These include the Russia-Ukraine war, rising inflation, higher interest rates, and the legacy of the COVID-19 pandemic.