ADC TECHNOLOGY MARKET (FOCUS ON ADC LINKER & ADC CONJUGATION TECHNOLOGIES): OVERVIEW
As per Roots Analysis, the global ADC technology market is estimated to grow from USD 1.18 billion in the current year to USD 4.37 billion by 2035, at a CAGR of 11.5% during the forecast period, till 2035.
The market sizing and opportunity analysis has been segmented across the following parameters:
Generation of Technology
- Third-Generation
- Second-Generation
- Next-Generation
Type of Conjugation
- Chemical
- Chemoenzymatic
- Enzymatic
Type of Linker
Type of Payment Model Adopted
- Upfront Payments
- Milestone Payments
Key Geographical Regions
- North America
- Europe
- Asia-Pacific and Rest of the World
ADC TECHNOLOGY MARKET (FOCUS ON ADC LINKER & ADC CONJUGATION TECHNOLOGIES): GROWTH AND TRENDS
Antibody drug conjugate has emerged as a versatile anti-cancer therapy that has been proven to be more effective and less toxic to patients. Such interventions are designed to identify specific antigens that are expressed on the surface of cancer (target) cells so that the effects of the cytotoxin / drug are focused on the elimination of only the cancerous cells. Over the past few years, more than 20 ADC therapies have been approved by various regulatory agencies. Moreover, over 350 drug therapies are being evaluated in clinical trials across the globe. This demonstrates the extensive development initiatives that are being undertaken by stakeholders in this domain. However, the complex design and structure of ADCs present a significant challenge to the overall tolerability and efficacy of the molecule. Thus, more advanced ADC technology is required to generate the controlled assembly of ADCs while maintaining tolerability and safety profiles. It is worth highlighting that significant investments have been made in the ADC technology market in order to meet the growing demand for antibody drug conjugates. As drug developers invest more in these innovative therapies, the market for ADC technology is likely to witness substantial market growth during the forecast period.
ADC TECHNOLOGY MARKET (FOCUS ON ADC LINKER & ADC CONJUGATION TECHNOLOGIES): KEY INSIGHTS
The report delves into the current state of the ADC technology market and identifies potential growth opportunities within the industry. Some key findings from the report include:
1. At present, over 95 ADC linker and conjugation technologies are being offered by various technology developers across the globe; around 55% of these are third-generation technologies.
2. The current market landscape is highly fragmented, featuring the presence of both new entrants and well-established players across key geographical regions.
3. Over 2,100 patents have been filed / granted for ADC linker and conjugation technologies, by industry and non-industry players, to protect the intellectual property generated within this field.
4. To cater to the increasing demand for homogenous ADC therapies, a number of players have stepped up to introduce technologically advanced platforms and establish a strong brand position in this industry.
5. A considerable increase in partnership activity has been witnessed in this domain; ~70% of the deals were related to licensing of technologies, primarily focused on product development and R&D purposes.
6. ADC drug developers are anticipated to continue to form strategic alliances with ADC linker and conjugation technology providers to further strengthen their respective technology portfolios.
7. Stakeholders have adopted different business models to maximize the gain from ADC technologies; a considerable number of players have signed multiple partnerships to out-license their technologies.
8. In pursuit of gaining a competitive edge, stakeholders are actively enhancing their existing capabilities to improve their respective technology portfolios and compliance with evolving industry standards.
9. At present, over 350 ADC therapeutic candidates are undergoing clinical trials for the treatment of various oncological disorders; majority of these ADCs are being evaluated as monotherapies.
10. With the growing focus on development of efficacious and site-selective drugs, the ADCs linker and conjugation technologies market is anticipated to witness an annualized growth of ~15%, over the next decade.
11. The estimated market opportunity is projected to be well distributed across different types of linkers and key geographical regions.
ADC TECHNOLOGY MARKET (FOCUS ON ADC LINKER & ADC CONJUGATION TECHNOLOGIES): KEY SEGMENTS
Third-Generation Technologies are Likely to Dominate the ADC Technology Market During the Forecast Period
Based on the generation of technology, the market is segmented into second-generation, third-generation and next-generation. It is worth highlighting that majority of the current ADC technology market is captured by third-generation technologies and this trend is likely to remain the same in the forthcoming years.
Currently, Chemical Conjugation Segment Occupies the Largest Share of the ADC Technology Market
Based on the type of conjugation, the market is segmented into chemical, chemoenzymatic and enzymatic. The current market is expected to be driven by chemical conjugators. It is worth highlighting that the chemoenzymatic segment is likely to grow at a relatively higher CAGR, during the forecast period.
Cleavable Segment is Likely to Capture the Largest Share of the ADC Technology Market During the Forecast Period
Based on the type of linker, the market is segmented into cleavable and non-cleavable. It is worth highlighting that majority of the current ADC technology market is captured by cleavable linkers and this trend is unlikely to change in the mid-long term.
North America Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, and Asia-Pacific and Rest of the World. A significant proportion of the market is expected to be captured by North America and Europe. It is worth highlighting that, over the years, the market in Asia-Pacific and Rest of the World is expected to grow at a higher CAGR.
Example Players in the ADC Technology Market
- Alteogen
- Ambrx
- Antikor
- Catalent Biologics
- Heidelberg Pharma
- Iksuda Therapeutics
- LegoChem Biosciences
- Mersana Therapeutics
- NBE-Therapeutics
- Seattle Genetics
- Sutro Biopharma
Primary Research Overview
The opinions and insights presented in this study were influenced by discussions conducted with multiple stakeholders. The research report features detailed transcripts of interviews held with the following industry stakeholders:
- Scientist, Abzena
- Chief Scientific Officer, MedLink Therapeutics
- Head of Business Development, Merck KGaA
- Board Member, Singzyme
- General Manager, Research and Development, Director of ADC Process Development, Ajinomoto
- Head of Research, Eucodis Bioscience
- Former Chief Business Officer, NBE-Therapeutics
- Chief Executive Officer, Shanghai Miracogen
- Chief Scientific Officer, Synaffix
ADC TECHNOLOGY MARKET (FOCUS ON ADC LINKER & ADC CONJUGATION TECHNOLOGIES): RESEARCH COVERAGE
- Market Sizing and Opportunity Analysis: The report features an in-depth analysis of the ADC linker and antibody conjugation technologies, focusing on key market segments, including [A] generation of technology, [B] type of conjugation, [C] type of linker, [D] type of payment model adopted and [E] key geographical regions.
- Market Landscape: A comprehensive evaluation of ADC linker and conjugation technologies, considering various parameters, such as [A] type of technology, [B] availability of licensing, [C] generation of ADC technology, [D] site specificity, [E] type of conjugation, [F] drug antibody ratio, [G] compatible linker, [H] conjugation chemistry, [I] conjugation site, [J] type of linker. It also includes information on ADC linker and antibody conjugation technology companies, based on several parameters, such as their [K] year of establishment, [L] company size (based on number of employees) and [M] location of headquarters.
- Technology Competitiveness Analysis: A comprehensive competitive analysis of ADC linker and conjugation technologies, examining factors, such as portfolio strength, technology competitiveness and partnership activity (in terms of number of partnerships). The analysis was designed to enable stakeholder companies to assess their existing capabilities and identify opportunities to achieve a competitive edge in the industry.
- Company Profiles: In-depth profiles of key industry players engaged in the development of ADC linker and ADC conjugation technologies, focusing on [A] company overviews, [B] technology portfolio, [C] insightful recent developments and [D] an informed future outlook.
- Patent Analysis: Detailed analysis of various patents filed / granted related to ADC linker and ADC conjugation technologies based on [A] type of patent, [B] publication year, [C] application year, [D] number of granted patents and patent applications, [E] patent jurisdiction, [F] focus area, [G] CPC symbols, [H] patent age, [I] type of applicant (on the basis of number of patents), and [J] individual patent assignees (in terms of size of intellectual property portfolio). In addition, it includes a patent benchmarking analysis and detailed valuation analysis.
- Partnerships and Collaborations: An analysis of partnerships established in this sector, since 2014, based on several parameters, such as [A] year of partnership, [B] type of partnership, [C] type of partner, [D] generation of technology, [E] type of linker, [F] type of conjugation, [G] target therapeutic area(s), [H] most popular technologies, [I] most active players and [J] geographical location of the companies.
- Business Model Analysis: An insightful analysis on business models adopted by various ADC technology providers engaged in this industry along with the information on parameters, such as [A] year of partnership, [B] purpose of partnership, [C] type of business strategy adopted (technology-out licensing, technology-in licensing, product out-licensing, product in-licensing, collaborative research and others), [D] type of investment, [E] amount invested and [F] most active players.
- Likely Partner Analysis: A detailed evaluation of several antibody drug conjugate therapeutics developers that are most likely to collaborate with ADC linker and conjugation technology companies in the near future. This analysis considers various relevant parameters, including [A] developer strength (in terms of company size and its experience), [B] portfolio strength (based on type of linker and antibody structure), [C] pipeline strength (based on stage of development of a drug and number of pre-clinical molecules) and [D] therapeutic area.
- Brand Positioning Analysis: An insightful brand positioning analysis of prominent antibody conjugation technology providers, highlighting the current perceptions regarding their proprietary technologies by taking into consideration several relevant aspects, such as [A] experience of the technology provider, [B] number of technologies offered, [C] product diversity, [D] number of patents and [E] number of partnerships.
- Case Study: The report includes a case study discussing the overall landscape of the antibody drug conjugates market, based on a number of parameters, such as [A] stage of development, [B] target disease indication, [C] therapeutics area, [D] line of treatment, [E] dosing frequency, [F] type of therapy, [G] target antigen, [H] antibody isotype, [I] payload / cytotoxin / warhead, [J] payload type, [K] type of linker. Further, it highlights information on antibody drug conjugate developers, including details on [L] year of establishment, [M] company size and [N] location of headquarters and [N] most active players in this domain.
KEY QUESTIONS ANSWERED IN THIS REPORT
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What kind of partnership models are commonly adopted by industry stakeholders?
- Which developers are most likely to collaborate with ADC linker and conjugation technology providers?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
REASONS TO BUY THIS REPORT
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
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