PUBLISHER: Roots Analysis | PRODUCT CODE: 1358247
PUBLISHER: Roots Analysis | PRODUCT CODE: 1358247
Pulsed field ablation market, a growing segment of the cardiac ablation market, is anticipated to grow at a compounded annual growth rate (CAGR) of ~40% during the forecast period 2023-2035.
Over the years, medical researchers and practitioners have actively pursued the development of minimally invasive procedures that are less painful, have shorter recovery periods, and offer improved patient outcomes. Such techniques have been able to carve out a niche in the huge atrial fibrillation market. Traditional treatment methods involving surgical procedures, though effective, are accompanied with a wide range of drawbacks, including extensive scarring, longer hospital stays, and a higher risk of complications. As a result, medical experts have turned their attention to ablation therapies, which involve the use of an energy source to destroy the abnormal tissues in the body without the need for invasive surgeries. Currently, several tissue ablation techniques are being employed for the treatment of a wide range of disease indications. However, the conventional ablation methods often rely on thermal energy which can potentially lead to tissue overheating, leading to necrosis of the surrounding healthy tissue. Moreover, these techniques are associated with post-procedural pain and discomfort that impact the patient's quality of life during recovery. As the limitations of traditional ablation methods became apparent, the demand for safer and more effective alternatives led to the emergence of pulsed field ablation (PFA).
Pulsed field ablation harnesses high-voltage electrical pulses delivered in short bursts. This non-thermal ablation process allows for precise targeting of abnormal tissues without causing collateral damage to surrounding healthy cells. By avoiding tissue overheating and charring, PFA ablation significantly reduces the risk of complications and post-procedural discomfort. Despite its applications across diverse medical specialties, pulsed field ablation has particularly shown significant promise in the treatment of cardiac rhythm-related disorders, including atrial fibrillation and ventricular tachycardia. Cardiac ablation through PFA involves the precise application of pulsed field electrical energy to create small scars in the cardiac tissue, effectively blocking irregular electrical signals and restoring a regular heartbeat. According to the Framingham Heart Study, over the past 50 years, the prevalence of atrial fibrillation has increased by three-fold. Owing to the rising disease burden of atrial fibrillation, as well as the ongoing research and development efforts to expand the applications of pulsed field ablation beyond cardiac ablation, the market is anticipated to witness remarkable market growth during the forecast period.
"The Pulsed Field Ablation Market: Distribution by Therapeutic Area (Cardiovascular Disorders, Oncological Disorders, Respiratory Disorders and Dermatological Disorders), Product Components (Catheters and Generators), Application Areas (Ablation, and Ablation and Mapping), Source of Ablation (Pulsed Field Energy, Pulsed Field and Radiofrequency Energy, and Pulsed Field and Cryoablation Energy), Key Geographical Regions (North America, Europe and Asia-Pacific): Market Share of Key Companies, Industry Trends and Global Forecasts, 2023-2035 report" features an extensive study of the current market landscape, market size and future opportunities associated with this industry, for the given forecast period. The market research report highlights the efforts of several stakeholders engaged in this emerging and rapidly evolving segment of the medical devices industry. Key takeaways of the pulsed field ablation market report are briefly discussed below.
Atrial Fibrillation (AF) is the most commonly occurring sustained cardiac arrhythmia affecting both men and women, across the globe. Its prevalence tends to rise with age in the general population. , Patients diagnosed with atrial fibrillation face a five-fold higher risk of stroke and a two-fold increased risk of death. According to the Global Burden of Disease, Injury and Risk Factor Study 2019, 59.7 million patients were afflicted with atrial fibrillation, globally. , Since the elderly population is at higher risk of developing atrial fibrillation, the rising ageing world population poses a threat of surged AF prevalence. In the US, around 9% of the population aged 65 and above is suffering from atrial fibrillation. In Europe, atrial fibrillation has emerged as one of the key public health problems, with its prevalence doubling over the last decade. Owing to the rapidly growing ageing population in the European countries, a 70% increase in the number of atrial fibrillation patients has been projected, over the next decade. Further, improved detection and diagnosis of atrial fibrillation has contributed to the growing number of reported cases of this disorder. Moreover, there are multiple modern lifestyle-related risk factors that play a role in the rapidly increasing prevalence of atrial fibrillation. These risk factors include hypertension, diabetes mellitus, smoking, alcohol consumption, obesity, lack of physical activity and psychological stress. Pulsed field ablation, a non-thermal modality, is proving to be a safe procedure for atrial fibrillation patients.
At present, several pulsed field ablation devices are available / being developed for therapeutic applications across cardiovascular disorders, oncological disorders, respiratory disorders, and dermatological disorders. In particular, pulsed field ablation devices have demonstrated high efficacy in treating and managing cardiac arrhythmias, while demonstrating selectivity for myocardial tissue and reducing the risk of esophageal injuries, pulmonary vein stenosis and phrenic nerve palsy. Amongst the various types of cardiac arrhythmias, PFA ablation is a proven modality for managing atrial fibrillation (persistent and paroxysmal), which is characterized by irregular beating of the atria (upper chambers) of the heart, due to which blood does not flow to the ventricles (lower chambers). The PFA ablation procedure primarily involves pulmonary vein isolation (PVI) procedure, which aims to restore normal heart rhythm by targeting and isolating the pulmonary veins, which are often the source of abnormal electrical signals that trigger atrial fibrillation. During the PVI procedure, catheters with electrodes are introduced into the heart through blood vessels. These catheters are guided to the pulmonary veins, and the electrodes deliver controlled electrical pulses to the tissue surrounding the pulmonary veins. The electrical pulses create lesions or scar tissue, which block the abnormal electrical signals from propagating to the rest of the atria. It is worth highlighting that beyond atrial fibrillation, the potential application of pulsed field ablation for the treatment of other cardiac arrythmias, including ventricular tachycardia and atrial flutter remains less explored.
In the field of oncology, pulsed field ablation has been used for the treatment of a wide range of solid tumors, including malignant tumors. Application of electrical pulses can alter the tumor microenvironment, inducing an inhibitory effect on tumors by killing the tumor cells and mobilizing the immune system to suppress tumor growth and invasion. In addition, chronic bronchitis, characterized by inflammation of the airways, can be treated through PFA's targeted ablation of the mucus producing cells lining the inner walls of bronchi. Pulsed field ablation has made significant strides in dermatology, providing an effective approach for precisely removing skin lesions, including both benign and pre-cancerous growths. The tissue selectivity of this type of ablative technology spares the non-cellular collagen foundation of the skin, allowing regeneration of target cells.
Multiple beneficial attributes of pulsed field ablation technology render it a higher safety profile as compared to other thermal ablation techniques. One of the distinguishing features of pulsed field ablation is its tissue-selective functionality, making it particularly valuable in facilitating cardiac ablation procedures by mitigating risks of phrenic palsy and esophageal injury. Even while targeting the cardiomyocytes, this technique spares stromal proteins from alterations, thereby preventing unintended coagulative necrosis and ensuring a more precise and controlled tissue ablation. Further, the delivery of pulsed field energy, whether through one-shot or point-by-point ablation procedures, creates transmural and durable atrial lesions, which effectively reduces the occurrence of pulmonary vein reconnection. , Depending on the specific medical condition and patient's need, electrophysiologists can tailor the electroporation procedure by varying various electrical parameters, such as voltage, number of pulses, pulse width, pulse shape, pulse delay and frequency. It is important to note that pulsed field ablation utilizes apoptosis to induce cell death, leading to a non-inflammatory response and quicker post-procedure recovery time.
The pulsed field ablation market features the presence of more than 45 pulsed field ablation devices. Of these, close to 90% of the devices comprise of ablation catheter as an intrinsic part of their product offering. Further, 39 pulsed field ablation devices are currently under various stages of development. In addition, the pulsed field ablation market features 35 companies that possess the necessary expertise to develop and commercialize pulsed field ablation devices. Currently, more than 40% of the pulsed field ablation companies engaged in this industry are small companies, with less than 50 employees. In terms of geographical presence, more than 50% of the pulsed field ablation companies are headquartered in North America. However, it is interesting to note that the majority of the pulsed field ablation devices have received regulatory approval in Europe.
At present, seven pulsed field ablation devices have received commercialization approval from various regulatory bodies around the globe. Of these, four devices, namely FARAPULSE™ Pulsed Field Ablation System (Boston Scientific), Affera™ Mapping and Ablation System (Medtronic), RheOx® system (Galvanize Therapeutics) and CENTAURI™ system (Galvanize Therapeutics) are available in Europe. FARAPULSE™ was the first PFA ablation system to receive CE mark in EU to treat atrial fibrillation and remained the only such system till the approval of CENTAURI™ in August 2022. Further, Medtronic's Affera™ is the latest pulsed field ablation catheter to receive CE mark in March 2023.
Further, two pulsed field ablation devices are approved in the US; these are Aliya™ system (Galvanize Therapeutics) for soft tissue ablation and CellFX System (Pulse Biosciences) for dermatological procedures. It is worth highlighting that NanoKnife System developed by AngioDynamics is the only pulsed field ablation device presently approved in China.
More than 70% of the commercialized PFA ablation devices are undergoing clinical trials in regions where they have not yet received approval. The ADVENT pivotal trial, being conducted at 34 locations across US, aims to evaluate the effectiveness of FARAPULSE™ Pulsed Field Ablation by Boston Scientific for the treatment of paroxysmal atrial fibrillation. In addition, a pilot-scale clinical trial, SPACE AF, is being carried out in Canada to evaluate the safety and efficacy of the CENTAURI™ system. , Further, Medtronic's PulseSelect™ Pulsed Field Ablation System is currently being evaluated in PULSED AF, a multi-center, non-randomized, global clinical trial, to assess its effectiveness for the treatment of atrial fibrillation. The device exceeded its performance goal with negligible side effects, thus proving its efficacy. In fact, the clinical study evaluating PulseSelect™ Pulsed Field Ablation System reported a primary adverse events rate of 0.7%, one of the lowest amongst those recorded for any prior FDA Investigational Device Exemption (IDE) trial for atrial fibrillation ablation device. In addition, there were no reported events of esophageal injury, pulmonary vein stenosis or phrenic nerve damage. It is worth highlighting that three pulsed field ablation devices, namely FARAPULSE™ Pulsed Field Ablation System (Boston Scientific), PulseSelect™ Pulsed Field Ablation System (Medtronic) and RheOx® system (Galvanize Therapeutics) have received breakthrough designation from the FDA. ,
Given the increasing prevalence of atrial fibrillation, high efficacy and safety profile of ablation through irreversible electroporation, the pulsed field ablation market size is anticipated to grow at an annualized rate (CAGR) of nearly 40% during the forecast period 2023-2035. It is worth highlighting that, in terms of therapeutic area, cardiovascular disorders segment is expected to capture the majority market share in the pulsed field ablation market in 2023 and this trend is likely to remain unchanged throughout the forecast period.
Examples of key pulsed field ablation companies (device developers which have also been profiled in this market report) include (in alphabetical order) Abbott, AccuPulse Medical, Acutus Medical, AngioDynamics, Arga Medtech, AtriAN Medical, Aurigen Medical, Biosense Webster, Boston Scientific, CathRx, ElectroPhysiology Frontiers, EnChannel Medical, Galvanize Therapeutics, Hangzhou Dinova EP Technology, Kardium, Medtronic, Mirai Medical, Pulse Biosciences and Tianjin Intelligent Health Medical. This market report includes an easily searchable excel database of all the pulsed field ablation companies worldwide.
Although the first direct current ablation was performed during the 1980s, the field gained momentum only after 2011, when PFA focused research to treat atrial fibrillation was initiated. Several developments have taken place in the field of pulsed field ablation, over the past few years. Some of these recent initiatives have been mentioned below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that we have been outlined in our analyses.
The market report presents an in-depth analysis, highlighting the capabilities of various pulsed field ablation companies, across different geographies. Amongst other elements, the market research report features:
The key objective of this market report is to provide a detailed market forecast analysis in order to estimate the existing market size and future opportunity for pulsed field ablation companies over the next decade. We have extensively studied the historical market data within this industry, in order to develop a deeper understanding of the evolutionary market trends. Based on multiple parameters, likely adoption trends and through primary validations, we have provided an informed estimate on the market evolution during the forecast period 2023-2035. The market report also features the likely distribution of the historical, current and forecasted opportunity within the pulsed field ablation market across various segments, such as therapeutic area (cardiovascular disorders, oncological disorders, respiratory disorders and dermatological disorders), product components (catheter and generator), application area (ablation, and ablation and mapping) and source of ablation (pulsed field energy, pulsed field and radiofrequency energy, and pulsed field and cryoablation energy) and geography (North America, Europe and Asia-Pacific). In addition, this report features the current and forecasted sales revenues of leading device developers engaged in this domain. In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry's market growth.
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market report are in USD, unless otherwise specified.
The data presented in this market report has been gathered via secondary research. For all our projects, we conduct interviews with experts in the area (academia, industry, medical practice and other associations) to solicit their opinions on emerging trends in the market. This is primarily useful for us to draw out our own opinion on how the market will evolve across different regions and technology segments. Where possible, the available data has been checked for accuracy from multiple sources of information.
While the focus has been on forecasting the market over the forecast period, the market report also provides our independent view of various technological and non-commercial trends emerging in the industry. This opinion is solely based on our knowledge, research and understanding of the market gathered from various secondary and primary sources of information.
Answer: Pulsed field ablation is a non-thermal ablation modality that destabilizes cell membrane by forming irreversible pores, eventually leading to cell death. The current pulsed field ablation technology is an adaptation of direct current ablation, which was first used to treat cardiac arrhythmia in the 1980s.
Answer: Pulsed field ablation operates on the mechanism of irreversible electroporation. When pulsed electric fields are applied to a cell, its intracellular charged species get redistributed, disrupting the transmembrane potential. This leads to the formation of artificial nanopores, hindering the cell's ability to maintain homeostasis. If the loss of homeostasis is of sufficient magnitude or duration, the cell cannot restore normal function and dies through either immediate necrosis or apoptosis.
Answer: Pulsed field ablation delivers short bursts of high amplitude electric current to kill abnormal tissues. In order to perform the ablation, a catheter is introduced into the human body, through a vein (femoral vein, for instance). Then the catheter is directed to the target organ (where ablation is to be performed) to ablate the abnormally functioning cells by creating transmural lesions.
Answer: Pulsed field ablation offers numerous benefits over conventional ablation techniques. These include:
Answer: Pulsed magnetic field radiofrequency ablation is an innovative technology that delivers radiofrequency oscillations at a rate of pulses per second. Such devices offer greater flexibility to electrophysiologists by allowing them to toggle between energy sources, while performing the ablation procedure.
Answer: Pulsed field ablation is currently available in Europe, with four commercialized devices in the market, of which three are approved for the treatment of atrial fibrillation, while one system is available for treating patients with chronic bronchitis. In the US, no pulsed field ablation device is commercially available for the treatment of atrial fibrillation. However, two PFA systems are approved for other indications in the US.
Answer: Several clinical studies have proven that the success rate of pulsed field ablation, in terms of freedom from recurrence of cardiac arrhythmias, is relatively higher than conventional ablation techniques. As per the recent results of the PULSED AF clinical trial conducted at 41 locations across the globe, pulsed field ablation device, PulseSelect™ Pulsed Field Ablation System, is associated with success rate of 80% for patients with paroxysmal atrial fibrillation and 81% for the persistent atrial fibrillation patients.
Answer: In 2021, FARAPULSE™ Pulsed Field Ablation System received CE mark approval for commercialization in the European Union (EU). It was the first PFA device to receive market authorization for the treatment of atrial fibrillation. However, it has not yet received approval from the FDA.
Answer: The pulsed field ablation market size is anticipated to grow at an annualized rate (CAGR) of nearly 30% during the forecast period 2023-2035.
Answer: Examples of key pulsed field ablation companies (device developers which have also been profiled in this market report) include (in alphabetical order) AccuPulse Medical, Acutus Medical, Adagio Medical, AngioDynamics, Arga Medtech, AtriAN Medical, Biosense Webster, Boston Scientific, CardioFocus, CathRx, CRC EP, Galvanize Therapeutics, Gradient Medical, Hangzhou Dinova EP Technology, Kardium, Medtronic, Mirai Medical, Pulse Biosciences and Tianjin Intelligent Health Medical.
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