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PUBLISHER: Mellalta Meets LLP | PRODUCT CODE: 1634517

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PUBLISHER: Mellalta Meets LLP | PRODUCT CODE: 1634517

Leptomeningeal Metastases | Primary Research (KOL's Insight) | Market Intelligence | Epidemiology & Market Forecast-2035

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Leptomeningeal carcinomatosis (LC), often referred to as "leptomeningeal metastasis" or "carcinomatosis meningitis," is a condition in which cancer has spread to the pia and arachnoid mater of the brain, as well as the subarachnoid space in between. Leptomeningeal metastases (LM) are detected in 1-8% of cancer patients and are found in 19% of individuals with cancer and neurologic signs and symptoms at autopsy, typically in those with widespread systemic illness. 1-5% of people with solid tumours, 5-15% of people with leukaemia, and 1% of people with primary brain tumours have LM. A promising sign of scientific advancement and patient advocacy is the recent introduction of clinical trials created especially for individuals with leptomeningeal metastases as well as brain metastases.

Description

Leptomeningeal carcinomatosis (LC), also known as "leptomeningeal metastasis" or "carcinomatosis meningitis," is a condition in which cancer has spread to the pia and arachnoid mater of the brain as well as the subarachnoid space in between. A lot of recent research has been done on the subject after it was first mentioned in the late 19th century. Studies have shown that solid tumors that involve the leptomeninges, such as brain tumors and haematological malignancies, are capable of metastasizing. It is a rare and late consequence that occurs in 5%-8% of solid tumor cases and 5%-15% of haematological cancer cases. Additionally, it implies a dismal outlook and few treatment options.

Leptomeningeal Metastases (Epidemiology)

Leptomeningeal metastases (LM) are found in 1-8% of cancer patients and 1-9% of people with cancer and neurologic symptoms at autopsy, usually in people with severe systemic illness. LM affects 1-5% of patients with solid tumors, 5-15% of patients with leukemia, and 1% of patients with primary brain tumors. It might be difficult to estimate the actual incidence of LM, which can range from 5 to 10% of cases. The gross autopsy examination may miss the LM if a non-affected area of the CNS is probed or if the seeding is multifocal, but the microscopic pathologic examination findings may be normal. The frequency of LM increases with the duration of a patient's primary cancer. The more frequently LM occurs, the longer a patient has the primary malignancy. LM is accompanied by additional cerebral metastases in 98% of patients with primary cancer that are not leukemic. With systemic cancer patients living longer, LM is becoming more common.

Leptomeningeal Metastases -Current Market Size & Forecast Trends

The market for leptomeningeal metastases is expected to grow significantly, with an estimated size of approximately USD 1.3 billion in 2021 across the major markets. This growth is driven by an increasing incidence of leptomeningeal metastases, which affects around 2.9 million patients in these regions. The market is projected to expand further as new treatment options and diagnostic approaches are developed, addressing the specific needs of this patient population. Emerging therapies in the pipeline, such as Rhenium-186 NanoLiposome and AZD1390, are anticipated to enhance treatment efficacy and improve patient outcomes. Overall, the leptomeningeal metastases market is well-positioned for substantial growth through 2035, fueled by ongoing advancements in cancer therapeutics and a growing focus on targeted treatments for this challenging condition.

The recent introduction of clinical trials designed specifically for people with leptomeningeal metastases as well as brain metastases is a promising sign of scientific progress and patient advocacy. Along with other modern therapies that have been shown to have bioactivity in the CSF in small prospective trials and case reports, proton CSI is a safe and effective method of treating LM. It is important to look into any differences in drug responses between the leptomeningeal and cerebral compartments. As part of this investigation, specialized clinical protocols for LM, pharmacokinetic monitoring to ensure adequate CSF penetration, and biomarker analysis to check for potential therapeutic resistance pathways should all be used. For this underserved patient population, new treatments must be developed, and the leptomeningeal immunological milieu and the molecular pathways underlying LM development must be further characterized. Omburtamab (Y-mAbs Therapeutics), TY 9591 (TYK Medicine), Tucatinib (Array BioPharma/Seagen), and other recently developed treatments have the potential to drive market expansion.

Report Highlights

Leptomeningeal Metastases - Current Market Trends

Leptomeningeal Metastases - Current & Forecasted Cases across the G8 Countries

Leptomeningeal Metastases - Market Opportunities and Sales Potential for Agents

Leptomeningeal Metastases - Patient-based Market Forecast to 2035

Leptomeningeal Metastases - Untapped Business Opportunities

Leptomeningeal Metastases - Product Positioning Vis-a-vis Competitors' Products

Leptomeningeal Metastases - KOLs Insight

Table of Content

1. Leptomeningeal Metastases Background

  • 1.1. Leptomeningeal Metastases Definition
  • 1.2. Signs and Symptoms
  • 1.3. Pathogenesis
  • 1.4. Clinical Manifestation
  • 1.5. Leptomeningeal Metastases biomarkers
  • 1.6. Diagnosis

2. Epidemiology Estimated and Forecast to 2035

  • 2.1. Epidemiology Research Method & Data Sources Used
  • 2.2. United States
    • 2.2.1. Incident Cases of Leptomeningeal Metastases
    • 2.2.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.3. United Kingdom
    • 2.3.1. Incident Cases of Leptomeningeal Metastases
    • 2.3.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.4. Spain
    • 2.4.1. Incident Cases of Leptomeningeal Metastases
    • 2.4.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.5. Germany
    • 2.5.1. Incident Cases of Leptomeningeal Metastases
    • 2.5.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.6. France
    • 2.6.1. Incident Cases of Leptomeningeal Metastases
    • 2.6.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.7. Italy
    • 2.7.1. Incident Cases of Leptomeningeal Metastases
    • 2.7.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.8. Japan
    • 2.8.1. Incident Cases of Leptomeningeal Metastases
    • 2.8.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.9. China
    • 2.9.1. Incident Cases of Leptomeningeal Metastases
    • 2.9.2. Diagnosed and treatable cases of Leptomeningeal Metastases by line of therapies (LOT)
  • 2.10. Current Unmet Needs in Leptomeningeal Metastases

3. Current Treatment Paradigm

  • 3.1. Treatment/Prevention guidelines
  • 3.2. Regulatory Approvals/Indication and Current Benchmarks

4. KOLs Insight (US, EU, JP, CH)

  • 4.1. Unmet Needs
  • 4.2. Analysis of the progress in terms of approvals & current pipeline
  • 4.3. Impact on the treatment algorithm and product positioning
  • 4.4. Relevance of new targets/platforms/ Therapy Uptake Share %
  • 4.5. Physicians Preferences for the new pharmacological agents

5. What's New in 2024/2025

6. Future Treatment Paradigm

  • 6.1. Leptomeningeal Metastases Competitor Landscape and Approvals Anticipated
  • 6.2. Future Treatment Algorithms and Competitor Positioning
  • 6.3. Key Data Summary for Emerging Treatment

7. Late Phase Therapies Strategic Considerations in Leptomeningeal Metastases

8. Total Market Forecast

  • 8.1. Key Summary Findings
    • 8.1.1. G8 total Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 8.1.2. G8 total Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)

9. Market Forecast by Country

  • 9.1. United States
    • 9.1.1. United States Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.1.2. United States Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.2. Germany
    • 9.2.1. Germany Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.2.2. Germany Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.3. France
    • 9.3.1. France Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.3.2. France Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.4. Italy
    • 9.4.1. Italy Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.4.2. Italy Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.5. Spain
    • 9.5.1. Spain Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.5.2. Spain Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.6. United Kingdom
    • 9.6.1. United Kingdom Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.6.2. United Kingdom Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.7. Japan
    • 9.7.1. Japan Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.7.2. Japan Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)
  • 9.8. China
    • 9.8.1. China Market for Leptomeningeal Metastases 2022-2035 (USD Million)
    • 9.8.2. China Market for Leptomeningeal Metastases by Therapies 2022-2035 (USD Million)

10. Market Drivers and Barriers

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Jeroen Van Heghe

Manager - EMEA

+32-2-535-7543

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Christine Sirois

Manager - Americas

+1-860-674-8796

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