PUBLISHER: KuicK Research | PRODUCT CODE: 1627538
PUBLISHER: KuicK Research | PRODUCT CODE: 1627538
Molecular Switches As Therapeutic Targets, Drug Development, Drug Delivery Mechanism & Application By Indications Insight 2025
Molecular Switches As Therapeutic Targets, Drug Development, Drug Delivery Mechanism & Application By Indications Insight 2025 Research Insights:
- Top 20 Drugs Sales Targeting Molecular Switches: 2022 - 2024
- Molecular Switches Significance In Regenerative Medicine & Nanomedicine
- Molecular Switches Significance In Drug Delivery & Release
- Molecular Switches Significance As Therapeutic Targets
- Molecular Switches In Cancer Therapeutics: Breast Cancer, Prostate Cancer, Lung Cancer, Colorectal Cancer, Gastric Cancer
- Molecular Switches In Neurological Disorder: Parkinson's Disease, Alzheimer's Disease, Multiple Sclerosis
- Molecular Switches In Autoimmune & Inflammatory Disorder: Diabetes, Arthritis, Lupus, Psoriasis
Molecular switches are dynamic entities capable of transitioning between distinct states in response to specific environmental or biological triggers. These triggers can include changes in pH, light exposure, temperature, redox conditions, or the presence of certain ions or biomolecules. The concept of molecular switching has significantly influenced the medical and pharmaceutical domain by providing a foundation for highly controlled diagnostic and therapeutic systems. The ability to precisely regulate biological responses has made molecular switches indispensable in the development of advanced drug delivery systems, real-time diagnostic tools, and personalized therapeutic interventions.
In the pharmaceutical sector, molecular switches have revolutionized drug delivery by enabling precise spatiotemporal control over the release of active pharmaceutical ingredients. One of the most widely explored triggers is pH, as pathological conditions like cancer and inflammation often create acidic microenvironments. pH-sensitive molecular switches are employed in nanoparticle-based drug carriers, which remain stable under normal physiological conditions but disassemble in acidic environments to release their payload. For example, the FPBC@SN nanoparticle system integrates a pH-sensitive molecular switch to target acidic cytoplasm in breast cancer cells. This system releases both sorafenib, which induces ferroptosis, and an IDO inhibitor to enhance tumor immunity. By leveraging such switches, these systems reduce off-target effects and enhance the therapeutic index, addressing key challenges in oncology.
Table of Contents
1. Introduction To Molecular Switches
- 1.1 Overview
- 1.2 History & Emergence In Medicine
2. Molecular Switches Clinical Significance In Medicine
3. Molecular Switches Significance In Drug Delivery & Release
- 3.1 Overview
- 3.2 Ongoing Research & Developments
4. Molecular Switches Significance As Therapeutic Targets
5. Molecular Switches - Broad Classification
6. Molecular Switches By Cancer Indication
- 6.1 Breast Cancer
- 6.2 Prostate Cancer
- 6.3 Colorectal cancer
- 6.4 Lung Cancer
- 6.5 Gastric Cancer
7. Molecular Switches By Neurological Disorder
- 7.1 Parkinson's Disease
- 7.2 Alzheimer's Disease
- 7.3 Multiple Sclerosis
8. Molecular Switches By Infectious Disease
- 8.1 Viral Infection
- 8.2 Bacterial Infection
9. Molecular Switches By Autoimmune & Inflammatory Disorder
- 9.1 Diabetes
- 9.2 Arthritis
- 9.3 Lupus
- 9.4 Psoriasis
10. Molecular Switches By Cardiovascular Disease
- 10.1 Myocardial Infarction (Heart Attack)
- 10.2 Others
11. Molecular Switches Significance In Regenerative Medicine
12. Sales Insight Of Key Drugs Targeting Molecular Switches
13. Molecular Switches In Drug Formulation
- 13.1 Smart Drug Formulations & Molecular Switches
- 13.2 Biomaterial Based Drug Delivery Systems
- 13.3 Self Regulating Drug Systems
14. Current Trends & Emerging Technologies
- 14.1 Molecular Switches In Nanomedicine
- 14.2 Innovations In Responsive Drug Systems
- 14.3 Integration With Artificial Intelligence & Machine Learning
15. Future Perspectives & Directions
- 15.1 Advancements In Molecular Switch Technology
- 15.2 The Future Of Personalized Medicine With Molecular Switches
- 15.3 Potential Impact On Drug Discovery & Therapeutics
List of Figures
- Figure 1-1: Molecular Switches - Introduction
- Figure 1-2: Molecular Switches - Emergence & Evolution
- Figure 3-1: Molecular Switches In Drug Delivery & Release
- Figure 3-2: Drug Delivery Systems With Molecular Switches
- Figure 3-3: Peptide-Based Drug Delivery System
- Figure 3-4: Switchable Molecular Tweezers
- Figure 3-5: Rotaxane-Based Drug Delivery System
- Figure 3-6: Enzyme-Activatable Drug Delivery System
- Figure 3-7: Light-Responsive Drug Delivery Systems
- Figure 3-8: Photo-Responsive Drug Delivery Using Spiropyran
- Figure 3-9: Photopharmacological Approach For Neuropathic Pain
- Figure 3-10: Insulin Prodrug Activation
- Figure 6-1: AR Activation & Its Dual Role In Tumor Growth
- Figure 6-2: PRL-3 Activation & AMPI-109's Impact On TNBC
- Figure 6-3: Molecular Switch in Prostate Cancer
- Figure 7-1: PINK1-Parkin Molecular Switch In Parkinson's Disease
- Figure 8-1: Molecular Switches In Viral infections
Figure 11 1: Molecular Switches In Regenerative Medicine
- Figure 13-1: Smart Drug Delivery With Molecular Switches
- Figure 13-2: Biomaterial Based Drug Delivery Systems With Molecular Switches
- Figure 13-3: Self-regulating Drug Systems With Molecular Switches
- Figure 14-1: Molecular Switches In Nanomedicine
- Figure 14-2: Molecular switches In Responsive Drug Systems
- Figure 14-3: Integration Of Molecular Switches With Artificial Intelligence & Machine Learning
List of Tables
- Table 1-1: Traditional v/s Molecular Switch Enabled Drug Delivery
- Table 4-1: Examples Of Approved Drugs Targeting Molecular Switches
- Table 5-1: Molecular Switches - Broad Classification
- Table 12-1: Top 20 Drugs Targeting Molecular Switches (US$ Billion), 2022-2024
