Base Editing Market by Component, Type, Technique, Application, End-use

List of Tables

[183 Pages Report] The Base Editing Market size was estimated at USD 277.65 million in 2023 and expected to reach USD 319.93 million in 2024, at a CAGR 16.01% to reach USD 785.47 million by 2030.

Base Editing is a form of precision genome editing technique that enables the direct, irreversible conversion of one DNA base pair into another at a specific location in the genome without requiring a double-stranded DNA break or a donor DNA template. This innovative approach uses a fusion protein consisting of a catalytically disabled CRISPR-Cas9 linked to a base deaminase enzyme. By targeting the desired genomic loci with guide RNA, base editors can induce point mutations by chemically modifying the DNA bases, leading to a base pair substitution after DNA replication. This technique offers potential applications in therapeutic gene editing, research on disease genetics, and the development of new agricultural products. This market includes the development and sales of base editing tools, services, consumables, and various applications in therapeutic development, agriculture, and biotechnology research. The applications of base editing are vast and varied. In the therapeutic space, base editing is used to correct single-point mutations that cause genetic diseases. Base editing can develop crops with beneficial traits such as disease resistance or increased yield in agriculture. For research and development, it is an invaluable tool for understanding gene function and creating models of human disease. The market scope for base editing includes pharmaceutical companies developing gene therapies, agricultural biotechnology firms, and academic and research institutions. Key factors influencing the growth of base editing include rising government funding and growing focus on genomic studies, expanding the application of genomics in the pharmaceutical sector, and increasing prevalence of rare diseases. Additionally, strategic collaborations among biotech firms and research organizations fuel market expansion. However, the base editing market faces several limitations and challenges, such as issues associated with ethics and safety and stringent regulations regarding base editing. On the other hand, the expanding application of base editing in the agricultural sector and increasing preference for personalized medicine worldwide present opportunities for expanding base editing.

KEY MARKET STATISTICS
Base Year [2023]	USD 277.65 million
Estimated Year [2024]	USD 319.93 million
Forecast Year [2030]	USD 785.47 million
CAGR (%)	16.01%

Regional Insights

In North America, the United States and Canada are at the forefront of base editing research and applications, with the presence of major biotechnology companies, heavy investments in gene editing technologies, and a favorable regulatory environment contributing to the rapid adoption of base editing. Partnerships between academic institutions and biotech firms are fueling innovation, with an emphasis on therapeutic applications to treat genetic disorders. South America has shown an increased interest in base editing, particularly in the areas of agriculture and crop improvement. Countries such as Brazil and Argentina are investing in biotechnology to bolster their vast agricultural sectors, using base editing to enhance crop resilience and productivity. The APAC region is experiencing substantial growth in the base editing market due to the rise in genetic research and increased investments in biotechnology. Countries such as China and Japan are at the forefront, with China leading in research output and patented technologies. China, in particular, has made headlines with significant advancements in gene editing and is actively implementing base editing in clinical research. Japan is notable for its precise regulatory framework, which balances innovation with ethical considerations. Europe boasts a strong pharmaceutical industry and a robust research environment, which propels the adoption of base editing technology. With the European Union's active support for gene editing research through various funding initiatives, several European countries are making notable contributions to the field. The Middle East has seen increased investment in healthcare innovation, particularly in nations such as Saudi Arabia and the United Arab Emirates, where base editing is emerging as a tool for medical research and potential treatments. In Africa, while the technology is still developing, it has the prospect of addressing critical challenges in healthcare and agriculture. Capacity building through international partnerships and educational initiatives is essential for the expansion of base editing in the region.

Market Insights

Market Dynamics

The market dynamics represent an ever-changing landscape of the Base Editing Market by providing actionable insights into factors, including supply and demand levels. Accounting for these factors helps design strategies, make investments, and formulate developments to capitalize on future opportunities. In addition, these factors assist in avoiding potential pitfalls related to political, geographical, technical, social, and economic conditions, highlighting consumer behaviors and influencing manufacturing costs and purchasing decisions.

Market Drivers
- Rising government funding and growing focus on genomic studies
- Expanding the application of genomics in pharmaceutical sector
- Increasing prevalence of rare diseases

Market Restraints
- Issues associated with ethics and safety

Market Opportunities
- Expanding application of base editing in the agricultural sector
- Increasing preference for personalized medicine worldwide

Market Challenges
- Stringent regulations regarding base editing

Market Segmentation Analysis
- Component: Increasing preference for base editing services for external services
- Type: Expanding usage of DNA base editing for high precision
- Application: Growing application of base editing for drug discovery & development
- End-use: Growing adoption of base editing in academic & research institutes

Market Disruption Analysis
Porter's Five Forces Analysis
Value Chain & Critical Path Analysis
Pricing Analysis
Technology Analysis
Patent Analysis
Trade Analysis
Regulatory Framework Analysis

FPNV Positioning Matrix

The FPNV positioning matrix is essential in evaluating the market positioning of the vendors in the Base Editing Market. This matrix offers a comprehensive assessment of vendors, examining critical metrics related to business strategy and product satisfaction. This in-depth assessment empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success, namely Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The market share analysis is a comprehensive tool that provides an insightful and in-depth assessment of the current state of vendors in the Base Editing Market. By meticulously comparing and analyzing vendor contributions, companies are offered a greater understanding of their performance and the challenges they face when competing for market share. These contributions include overall revenue, customer base, and other vital metrics. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With these illustrative details, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Recent Developments

Beam Announces Agreement for Lilly to Acquire Beam's Opt-In Rights to Verve Therapeutics' Base Editing Programs for Cardiovascular Disease

Beam Therapeutics Inc., a prominent provider in base editing technology, has crafted a strategic alliance with Eli Lilly and Company, a pharmaceutical company. Lilly is expected to acquire rights from Beam's updated agreement with Verve Therapeutics, Inc., taking a significant step forward with co-development and co-commercialization options for programs targeting key cardiovascular disease markers like PCSK9 and ANGPTL3-plus an undisclosed target. [Published On: 2023-10-31]

Revvity Expands Access to Base Editing Technology With Aim to Accelerate Discovery to Cure

Revvity Inc. has launched its state-of-the-art Pin-point base editing platform reagents, heralding a new era in CRISPR gene editing technology for preclinical research researchers. With the ability to carry out precision single base changes across various genomic sites, Revvity's Pin-point platform enhances functional genomics, aiding in the optimization of drug development and the simplification of cell line and cell therapy production. [Published On: 2023-09-26]

Researchers develop new base editing tools using AI-predicted protein structure clustering

The research team at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, has significantly advanced the field of base editing with their groundbreaking use of artificial intelligence. By leveraging the AlphaFold2 platform to predict and classify structures of deaminase proteins, they have made strides in identifying novel enzymes with unique functions. These enzymes have paved the way for the innovation of custom genetic traits in plants, addressing previous limitations in gene editing due to sequence specificity and organism compatibility. Their research led to the development of various new base editors, which exhibit enhanced efficiencies, minimized off-target effects, and are adaptable to preferred sequence contexts. [Published On: 2023-06-27]

Strategy Analysis & Recommendation

The strategic analysis is essential for organizations seeking a solid foothold in the global marketplace. Companies are better positioned to make informed decisions that align with their long-term aspirations by thoroughly evaluating their current standing in the Base Editing Market. This critical assessment involves a thorough analysis of the organization's resources, capabilities, and overall performance to identify its core strengths and areas for improvement.

Key Company Profiles

The report delves into recent significant developments in the Base Editing Market, highlighting leading vendors and their innovative profiles. These include Addgene, Inc., Beam Therapeutics, Beijing Qi Biodesign Biotechnology Company Limited, Bio Palette Co., Ltd., Creative Biogene, DH Life Sciences, LLC, Editas Medicine, Inc., ElevateBio, LLC, GenScript Biotech Corporation, Intellia Therapeutics, Inc., KromaTiD Inc., Pairwise Plants Services, ProQR Therapeutics N.V., QIAGEN GmbH, Revvity, Inc., Sangamo Therapeutics, Inc., Synthego Corporation, Tecan Group, and TriLink BioTechnologies by Maravai LifeSciences.

Market Segmentation & Coverage

This research report categorizes the Base Editing Market to forecast the revenues and analyze trends in each of the following sub-markets:

Component
- Consumables
  - Base Editing Libraries
  - Kits & Reagents
  - Plasmids

Services
- Cell Line Engineering
- gRNA Design

Type
- DNA Base Editing
- RNA Base Editing

Technique
- CRISPR-Cas9
- TALE Nucleases
- Zinc-Finger Nucleases

Application
- Human Therapeutics
- Livestock
- Plant Breeding

End-use
- Academic & Research Institutes
- Contract Research Organizations
- Pharmaceutical & Biotechnology Companies

Region
- Americas
  - Argentina
  - Brazil
  - Canada
  - Mexico
  - United States
    - California
    - Florida
    - Illinois
    - New York
    - Ohio
    - Pennsylvania
    - Texas
- Asia-Pacific
  - Australia
  - China
  - India
  - Indonesia
  - Japan
  - Malaysia
  - Philippines
  - Singapore
  - South Korea
  - Taiwan
  - Thailand
  - Vietnam

Europe, Middle East & Africa
- Denmark
- Egypt
- Finland
- France
- Germany
- Israel
- Italy
- Netherlands
- Nigeria
- Norway
- Poland
- Qatar
- Russia
- Saudi Arabia
- South Africa
- Spain
- Sweden
- Switzerland
- Turkey
- United Arab Emirates
- United Kingdom

Product Code: MRR-F3183FD145E1

1. Preface

1.1. Objectives of the Study
1.2. Market Segmentation & Coverage
1.3. Years Considered for the Study
1.4. Currency & Pricing
1.5. Language
1.6. Stakeholders

2. Research Methodology

2.1. Define: Research Objective
2.2. Determine: Research Design
2.3. Prepare: Research Instrument
2.4. Collect: Data Source
2.5. Analyze: Data Interpretation
2.6. Formulate: Data Verification
2.7. Publish: Research Report
2.8. Repeat: Report Update

3. Executive Summary

4. Market Overview

5. Market Insights

5.1. Market Dynamics
- 5.1.1. Drivers
  - 5.1.1.1. Rising government funding and growing focus on genomic studies
  - 5.1.1.2. Expanding the application of genomics in pharmaceutical sector
  - 5.1.1.3. Increasing prevalence of rare diseases
- 5.1.2. Restraints
  - 5.1.2.1. Issues associated with ethics and safety
- 5.1.3. Opportunities
  - 5.1.3.1. Expanding application of base editing in the agricultural sector
  - 5.1.3.2. Increasing preference for personalized medicine worldwide
- 5.1.4. Challenges
  - 5.1.4.1. Stringent regulations regarding base editing
5.2. Market Segmentation Analysis
- 5.2.1. Component: Increasing preference for base editing services for external services
- 5.2.2. Type: Expanding usage of DNA base editing for high precision
- 5.2.3. Application: Growing application of base editing for drug discovery & development
- 5.2.4. End-use: Growing adoption of base editing in academic & research institutes
5.3. Market Disruption Analysis
5.4. Porter's Five Forces Analysis
- 5.4.1. Threat of New Entrants
- 5.4.2. Threat of Substitutes
- 5.4.3. Bargaining Power of Customers
- 5.4.4. Bargaining Power of Suppliers
- 5.4.5. Industry Rivalry
5.5. Value Chain & Critical Path Analysis
5.6. Pricing Analysis
5.7. Technology Analysis
5.8. Patent Analysis
5.9. Trade Analysis
5.10. Regulatory Framework Analysis

6. Base Editing Market, by Component

6.1. Introduction
6.2. Consumables
6.3. Services

7. Base Editing Market, by Type

7.1. Introduction
7.2. DNA Base Editing
7.3. RNA Base Editing

8. Base Editing Market, by Technique

8.1. Introduction
8.2. CRISPR-Cas9
8.3. TALE Nucleases
8.4. Zinc-Finger Nucleases

9. Base Editing Market, by Application

9.1. Introduction
9.2. Human Therapeutics
9.3. Livestock
9.4. Plant Breeding

10. Base Editing Market, by End-use

10.1. Introduction
10.2. Academic & Research Institutes
10.3. Contract Research Organizations
10.4. Pharmaceutical & Biotechnology Companies

11. Americas Base Editing Market

11.1. Introduction
11.2. Argentina
11.3. Brazil
11.4. Canada
11.5. Mexico
11.6. United States

12. Asia-Pacific Base Editing Market

12.1. Introduction
12.2. Australia
12.3. China
12.4. India
12.5. Indonesia
12.6. Japan
12.7. Malaysia
12.8. Philippines
12.9. Singapore
12.10. South Korea
12.11. Taiwan
12.12. Thailand
12.13. Vietnam

13. Europe, Middle East & Africa Base Editing Market

13.1. Introduction
13.2. Denmark
13.3. Egypt
13.4. Finland
13.5. France
13.6. Germany
13.7. Israel
13.8. Italy
13.9. Netherlands
13.10. Nigeria
13.11. Norway
13.12. Poland
13.13. Qatar
13.14. Russia
13.15. Saudi Arabia
13.16. South Africa
13.17. Spain
13.18. Sweden
13.19. Switzerland
13.20. Turkey
13.21. United Arab Emirates
13.22. United Kingdom

14. Competitive Landscape

14.1. Market Share Analysis, 2023
14.2. FPNV Positioning Matrix, 2023
14.3. Competitive Scenario Analysis
- 14.3.1. Beam Announces Agreement for Lilly to Acquire Beam's Opt-In Rights to Verve Therapeutics' Base Editing Programs for Cardiovascular Disease
- 14.3.2. Revvity Expands Access to Base Editing Technology With Aim to Accelerate Discovery to Cure
- 14.3.3. Researchers develop new base editing tools using AI-predicted protein structure clustering
- 14.3.4. Pfizer and Beam Enter Exclusive Multi-Target Research Collaboration to Advance Novel In Vivo Base Editing Programs for a Range of Rare Diseases
14.4. Strategy Analysis & Recommendation

15. Competitive Portfolio

15.1. Key Company Profiles
15.2. Key Product Portfolio