Gene Therapy Market by Type, Vector Type, Application

List of Tables

[196 Pages Report] The Gene Therapy Market size was estimated at USD 5.67 billion in 2023 and expected to reach USD 7.05 billion in 2024, at a CAGR 27.15% to reach USD 30.48 billion by 2030.

Gene therapy is a medical procedure that introduces, alters, or corrects genetic material within an individual's cells to treat or prevent disease. The primary purpose of gene therapy is to address genetic disorders by replacing or repairing faulty genes, introducing therapeutic genes, or regulating the expression of genes. This field holds great promise for treating various genetic and acquired diseases at their root cause. Several factors are contributing to the growth of the gene therapy market, including an increase in the prevalence of chronic conditions, a rise in acceptance of gene therapy treatment, a surge in clinical trials, and escalated R&D expenditure in the pharmaceutical sector. However, the cost of these therapies is exceptionally high, accompanied by a complex and lengthy development process. Additionally, concerns regarding off-target effects, immunogenicity, and long-term safety may hamper its market demand. Moreover, advanced technology development has opened several previously inaccessible gene editing and therapy frontiers. The gene therapy market is anticipated to grow further due to regulatory authorities' rising approval of gene therapy products, which brought forth many potential opportunities with targeted disease treatments.

KEY MARKET STATISTICS
Base Year [2023]	USD 5.67 billion
Estimated Year [2024]	USD 7.05 billion
Forecast Year [2030]	USD 30.48 billion
CAGR (%)	27.15%

Type: Prevalence of cancer gene therapy for cancer treatment

Antigen gene therapy introduces genes that encode specific antigens into a patient's cells. The goal is stimulating the immune system to recognize and mount an immune response against cells expressing these antigens. This approach is often explored in cancer immunotherapy, where the immune system is encouraged to target and eliminate cancer cells. Cancer gene therapy aims to treat or eliminate cancer by targeting specific aspects of cancer cells. This therapy uses gene editing technologies to modify or correct specific genetic mutations associated with cancer. Cytokine gene therapy involves introducing genes encoding specific cytokines into the patient's cells. This approach aims to enhance the immune system's capacity to identify and eliminate cancer cells by introducing genes that produce immune-stimulating cytokines. Suicide gene therapy, also known as gene-directed enzyme prodrug therapy (GDEPT), involves introducing a gene that encodes an enzyme into target cells. The enzyme produced by the gene activates a prodrug (a non-toxic substance), converting it into a toxic drug selectively in the target cells. This approach is often used in cancer therapy to cause apoptosis in cancer cells. Tumor suppressor gene therapy focuses on restoring or enhancing the function of tumor suppressor genes. Tumor suppressor gene therapy aims to either replace or activate these genes to control or inhibit the growth of cancer cells.

Vector Type: Significant utilization of viral vector providing higher efficiency in delivering genes into cells

Non-viral vectors in gene therapy are carriers or delivery systems that do not involve viruses. These vectors transport therapeutic genetic material, such as DNA or RNA, into target cells to treat or prevent diseases. Non-viral vectors are considered safer in terms of immunogenicity than viral vectors and have some advantages in terms of ease of production and reduced risk of integration into the host genome. Viral vectors are vehicles or carriers derived from viruses modified to deliver therapeutic genetic material into target cells as part of gene therapy. These vectors are engineered to be safe and effective, taking advantage of the natural ability of viruses to enter cells and deliver their genetic payload. Viral vectors are key to many gene therapy strategies because they efficiently deliver genes into cells.

Application: Potential adoption of gene therapy as a revolutionary approach to treating cardiovascular diseases

Gene therapy has appeared as a revolutionary method to treating cardiovascular diseases. It mainly focuses on delivering genes to replace, inactivate, or introduce new genetic material to cells to cure or manage cardiovascular illness. Advancements in gene therapy offer promising treatment pathways to hinder the progression of genetic diseases. Gene therapy holds significant promise in treating genetic diseases by addressing the underlying genetic abnormalities that cause these conditions. Gene therapy can play a role in combating infectious diseases through various strategies to enhance the host's immune response, develop antiviral agents, or directly target the infectious agent. Gene therapy holds promise for treating neurological diseases by addressing the underlying genetic and molecular abnormalities associated with these disorders. Gene therapy holds promise in oncology for treating various types of cancer. The goal of gene therapy in oncology is to target and modify the genetic factors contributing to cancer development, growth, and resistance to treatment.

Regional Insights

The Americas has a significant landscape in gene therapy owing to rising research and innovation with significant investments in this domain. The gene therapy market has witnessed exponential growth, mainly due to the improved prevalence of chronic diseases, availability of funding for genetic research, a strong presence of industry players, and FDA approvals that significantly impact gene therapy trends. The European region shows considerable growth in the gene therapy sector due to advanced research in gene therapy due to its well-established pharmaceutical companies. The European Union invests heavily in healthcare research, including gene therapy. Countries lead in therapeutic clinical trials, particularly in oncology, cardiovascular, and inherited diseases. The Asia-Pacific region is a rapidly emerging market in the arena of gene therapy. The surge in clinical trials spurred by its burgeoning biotech sector and substantial government funding, fast-track innovative gene therapy research is further fueled by expanded market demand. Overall, the APAC region's growth in gene therapy is driven by a combination of large patient populations, growing healthcare expenditure, and evolving regulatory environments.

FPNV Positioning Matrix

The FPNV Positioning Matrix is pivotal in evaluating the Gene Therapy Market. It offers a comprehensive assessment of vendors, examining key metrics related to Business Strategy and Product Satisfaction. This in-depth analysis empowers users to make well-informed decisions aligned with their requirements. Based on the evaluation, the vendors are then categorized into four distinct quadrants representing varying levels of success: Forefront (F), Pathfinder (P), Niche (N), or Vital (V).

Market Share Analysis

The Market Share Analysis is a comprehensive tool that provides an insightful and in-depth examination of the current state of vendors in the Gene Therapy Market. By meticulously comparing and analyzing vendor contributions in terms of overall revenue, customer base, and other key metrics, we can offer companies a greater understanding of their performance and the challenges they face when competing for market share. Additionally, this analysis provides valuable insights into the competitive nature of the sector, including factors such as accumulation, fragmentation dominance, and amalgamation traits observed over the base year period studied. With this expanded level of detail, vendors can make more informed decisions and devise effective strategies to gain a competitive edge in the market.

Key Company Profiles

The report delves into recent significant developments in the Gene Therapy Market, highlighting leading vendors and their innovative profiles. These include Abeona Therapeutics Inc., Adaptimmune Therapeutics PLC, AGC Biologics., Alnylam Pharmaceuticals, Inc., American Gene Technologies Inc., Amgen Inc., AnGes, Inc., Applied Genetic Technologies Corporation, Astellas Gene Therapies, Biogen Inc., Bluebird Bio, Inc., Cellectis, Inc., Editas Medicine, Inc., Human Stem Cells Institute, Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Mustang Bio, Novartis AG, Orchard Therapeutics PLC, Poseida Therapeutics, Inc., Sangamo Therapeutics, Inc., Sarepta Therapeutics, Inc., Shenzhen SiBiono GeneTech Co. Ltd., Spark Therapeutics, Inc., and Uniqure N.V..

Market Segmentation & Coverage

This research report categorizes the Gene Therapy Market to forecast the revenues and analyze trends in each of the following sub-markets:

Type
- Antigen Gene Therapy
- Cancer Gene Therapy
- Cytokine Gene Therapy
- Suicide Gene Therapy
- Tumor Suppressor Gene Therapy

Vector Type
- Non-viral Vectors
- Viral Vectors

Application
- Cardiovascular Diseases
- Genetic Diseases
- Infectious Diseases
- Neurological Diseases
- Oncological Disorders

Region
- Americas
  - Argentina
  - Brazil
  - Canada
  - Mexico
  - United States
    - California
    - Florida
    - Illinois
    - New York
    - Ohio
    - Pennsylvania
    - Texas
- Asia-Pacific
  - Australia
  - China
  - India
  - Indonesia
  - Japan
  - Malaysia
  - Philippines
  - Singapore
  - South Korea
  - Taiwan
  - Thailand
  - Vietnam

Europe, Middle East & Africa
- Denmark
- Egypt
- Finland
- France
- Germany
- Israel
- Italy
- Netherlands
- Nigeria
- Norway
- Poland
- Qatar
- Russia
- Saudi Arabia
- South Africa
- Spain
- Sweden
- Switzerland
- Turkey
- United Arab Emirates
- United Kingdom

The report offers valuable insights on the following aspects:

1. Market Penetration: It presents comprehensive information on the market provided by key players.

2. Market Development: It delves deep into lucrative emerging markets and analyzes the penetration across mature market segments.

3. Market Diversification: It provides detailed information on new product launches, untapped geographic regions, recent developments, and investments.

4. Competitive Assessment & Intelligence: It conducts an exhaustive assessment of market shares, strategies, products, certifications, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players.

5. Product Development & Innovation: It offers intelligent insights on future technologies, R&D activities, and breakthrough product developments.

The report addresses key questions such as:

1. What is the market size and forecast of the Gene Therapy Market?

2. Which products, segments, applications, and areas should one consider investing in over the forecast period in the Gene Therapy Market?

3. What are the technology trends and regulatory frameworks in the Gene Therapy Market?

4. What is the market share of the leading vendors in the Gene Therapy Market?

5. Which modes and strategic moves are suitable for entering the Gene Therapy Market?

Product Code: MRR-437517DB6C62

1. Preface

1.1. Objectives of the Study
1.2. Market Segmentation & Coverage
1.3. Years Considered for the Study
1.4. Currency & Pricing
1.5. Language
1.6. Stakeholders

2. Research Methodology

2.1. Define: Research Objective
2.2. Determine: Research Design
2.3. Prepare: Research Instrument
2.4. Collect: Data Source
2.5. Analyze: Data Interpretation
2.6. Formulate: Data Verification
2.7. Publish: Research Report
2.8. Repeat: Report Update

3. Executive Summary

4. Market Overview

5. Market Insights

5.1. Market Dynamics
- 5.1.1. Drivers
  - 5.1.1.1. Increasing Prevalence of Chronic Diseases and Upsurge in Number of Gene Therapy Treatment Centers
  - 5.1.1.2. Government Support and Ethical Acceptance of Gene Therapy For Treatments
- 5.1.2. Restraints
  - 5.1.2.1. High Costs Associated with Gene Therapies
- 5.1.3. Opportunities
  - 5.1.3.1. Ongoing Research & Development in Orphan Diseases and Advancements in Gene Therapy
  - 5.1.3.2. Innovative Payment Models and Favorable Regulatory Approvals
- 5.1.4. Challenges
  - 5.1.4.1. Potential Harmful Effects and Moral Concerns Regarding New Gene Therapy
5.2. Market Segmentation Analysis
- 5.2.1. Type: Prevalence of cancer gene therapy for cancer treatment
- 5.2.2. Vector Type: Significant utilization of viral vector providing higher efficiency in delivering genes into cells
- 5.2.3. Application: Potential adoption of gene therapy as a revolutionary approach to treating cardiovascular diseases
5.3. Market Trend Analysis
5.4. Cumulative Impact of Russia-Ukraine Conflict
5.5. Cumulative Impact of High Inflation
5.6. Porter's Five Forces Analysis
- 5.6.1. Threat of New Entrants
- 5.6.2. Threat of Substitutes
- 5.6.3. Bargaining Power of Customers
- 5.6.4. Bargaining Power of Suppliers
- 5.6.5. Industry Rivalry
5.7. Value Chain & Critical Path Analysis
5.8. Regulatory Framework Analysis
5.9. Client Customization

6. Gene Therapy Market, by Type

6.1. Introduction
6.2. Antigen Gene Therapy
6.3. Cancer Gene Therapy
6.4. Cytokine Gene Therapy
6.5. Suicide Gene Therapy
6.6. Tumor Suppressor Gene Therapy

7. Gene Therapy Market, by Vector Type

7.1. Introduction
7.2. Non-viral Vectors
7.3. Viral Vectors

8. Gene Therapy Market, by Application

8.1. Introduction
8.2. Cardiovascular Diseases
8.3. Genetic Diseases
8.4. Infectious Diseases
8.5. Neurological Diseases
8.6. Oncological Disorders

9. Americas Gene Therapy Market

9.1. Introduction
9.2. Argentina
9.3. Brazil
9.4. Canada
9.5. Mexico
9.6. United States

10. Asia-Pacific Gene Therapy Market

10.1. Introduction
10.2. Australia
10.3. China
10.4. India
10.5. Indonesia
10.6. Japan
10.7. Malaysia
10.8. Philippines
10.9. Singapore
10.10. South Korea
10.11. Taiwan
10.12. Thailand
10.13. Vietnam

11. Europe, Middle East & Africa Gene Therapy Market

11.1. Introduction
11.2. Denmark
11.3. Egypt
11.4. Finland
11.5. France
11.6. Germany
11.7. Israel
11.8. Italy
11.9. Netherlands
11.10. Nigeria
11.11. Norway
11.12. Poland
11.13. Qatar
11.14. Russia
11.15. Saudi Arabia
11.16. South Africa
11.17. Spain
11.18. Sweden
11.19. Switzerland
11.20. Turkey
11.21. United Arab Emirates
11.22. United Kingdom

12. Competitive Landscape

12.1. Market Share Analysis, 2023
12.2. FPNV Positioning Matrix, 2023
12.3. Competitive Scenario Analysis
- 12.3.1. Charles River Unveils Lentivation Platform to Expedite LVV-based Gene Therapy Manufacturing
- 12.3.2. Laurus to launch Gene Therapy Assets in India
- 12.3.3. Bluebird bio Lays Gene Therapy Launch Groundwork As Sickle Cell Application Nears

13. Competitive Portfolio

13.1. Key Company Profiles
13.2. Key Product Portfolio