PUBLISHER: Inkwood Research | PRODUCT CODE: 1516707
PUBLISHER: Inkwood Research | PRODUCT CODE: 1516707
Global Tcr Therapy Market Pipeline
KEY FINDINGS
TCR therapy, or T-cell receptor therapy, is an innovative form of immunotherapy that leverages the body's own immune system to combat cancer. This approach involves extracting a patient's T-cells and genetically engineering them to express receptors specifically designed to recognize and bind to cancer-associated antigens presented by the major histocompatibility complex (MHC) on tumor cells.
Unlike CAR-T therapy, which targets antigens on the cell surface, TCR therapy can target intracellular proteins, allowing for a broader range of cancer targets. Once engineered, these T-cells are expanded in the laboratory and reinfused into the patient, where they seek out and destroy cancer cells. TCR therapy holds significant promise for treating various cancers, including solid tumors, and is currently the focus of extensive research to optimize its efficacy and safety.
MARKET INSIGHTS
Key enablers of the global TCR therapy market growth:
- Growing number of promising clinical and preclinical studies
- Rising cancer incidence rates
According to the American Cancer Society, the United States is projected to see 1,958,310 new cancer cases and 609,820 cancer deaths in 2023. The rising incidence of cancer underscores the urgent need for more effective treatments, propelling TCR (T-cell receptor) therapy into the forefront. As cancer rates surge globally, the demand for innovative therapies like TCR, which harnesses the immune system to target cancer cells, is increasing.
With more patients being diagnosed with various forms of cancer, the market for TCR therapy naturally expands to address these diverse indications. This trend showcases the versatility of TCR therapy and its potential to meet the evolving needs of cancer patients, positioning it as a significant player in the field of oncology.
As more patients require advanced therapeutic options, TCR therapy's ability to specifically target cancer cells positions it as a promising solution. Its adaptability across different cancer types enhances its appeal, making TCR therapy a crucial component in the ongoing battle against cancer and a key factor in the future landscape of oncology treatments.
- Surge in innovation and research activities
Key growth restraining factors of the global TCR therapy market:
- Toxicity from cytokine storms in TCR therapy
- Off-target effects and safety concerns in TCR gene transfer
- Challenges in selecting the optimal target antigen
T-cell receptors (TCRs) can only recognize peptide-HLA complexes and are effective against cancer cells that have matching HLA alleles, necessitating appropriate HLA matching. This means that TCR-T-cells derived from non-Chinese individuals cannot be directly applied to Chinese patients. The screening process for identifying TCRs with the optimal affinity threshold is challenging, as high-affinity TCRs are needed to enhance immune responses.
Identifying TCRs with high affinity for antigens is crucial for effective immune responses, but the affinity must be carefully regulated. If TCR affinity exceeds physiological limits, it can result in injury to the T-cells.
The mechanism of antigen recognition by TCR-expressing T-cells is vital for T-cell immunity. T-cells must quantitatively respond to antigens presented by pathogens while remaining unresponsive to similar antigens on host tissues.
TCR Therapy | Overview
- Introduction
- Structural characteristics of the TCR
- TCR diversity in the pre-selection repertoire
The pre-selection repertoire of T-cell receptors (TCRs) is shaped by both genetic and epigenetic factors. According to the accessibility hypothesis, gene segments must be accessible to recombination machinery, involving processes such as subnuclear relocation, DNA methylation, chromatin remodeling, histone modification, and germline transcription.
Although the activation of the 3' proximal region of antigen receptor loci is well understood, the mechanisms controlling the accessibility and activation of the 5' V region remain unclear. Research has shown that V genes in the immunoglobulin heavy chain locus recombine at different frequencies even when they have equal accessibility, implying that similar biases might also be present in TCR loci.
Recent analyses reveal that the frequency of out-of-frame TCR-a sequences is affected by the usage of V and J segments, indicating a genetic influence. Additionally, recombination bias causes a notable overlap in the TCR-B chain repertoire among syngeneic mice before thymic selection, highlighting a predisposition in the TCR repertoire composition that is significantly shaped by V(D)J recombination.
- TCR diversity in the naive pool
- TCR diversity in health and disease
- TCR clonotypes as markers of disease
- The TCR complex
The TCR receptor complex is an octameric structure with three dimeric signaling modules: CD247 ζ/ζ, CD3δ/ε, and CD3Y/ε, and variable a and B chains. Ionizable residues in the transmembrane domains stabilize the complex, while signaling molecules are essential due to the TCR's short cytoplasmic tail.
TCRs exhibit low affinity for peptide/MHC ligands (dissociation constants of 1-100 μM); but T-cells maintain high antigen specificity and sensitivity through the formation of TCR microclusters, enhancing antigen recognition via an avidity-based mechanism.
Antigen-experienced T-cells (effector and memory) show increased sensitivity and require fewer costimulatory signals and lower antigen concentrations compared to naive T-cells, achieved through functional avidity maturation without changes in affinity.
- TCR co-receptors
- Associated molecules of the TCR complex involved in T-cell activation
- T-cell receptor-engineered T-cells for cancer treatment: Current status and future directions
- Identification of TCR sequences
- Improving the function of TCR-engineered T-cells in tumor microenvironment
COMPETITIVE INSIGHTS
Major players in the global TCR therapy market:
- Adaptimmune
- Gilead Sciences
- Alaunos Therapeutics
- Triumvira Immunologics
- Takara Bio
Gilead Sciences, a biopharmaceutical company established in 1987 in Foster City, California, specializes in researching, developing, and marketing medicines for life-threatening diseases. With over 7,000 employees spread across offices on six continents, Gilead focuses on therapeutic areas such as HIV/AIDS, hepatitis B and C, influenza, COVID-19, liver diseases, hematology, and oncology. Some of their notable products include Biktarvy, Complera, Descovy, Emtriva, Genvoya, Odefsey, Stribild, and Sunlenca.
KITE-439, developed by Gilead Sciences, is a T lymphocyte replacement therapy. Preclinical studies have shown efficacy with MHC class I-restricted T-cell receptor (TCR)-engineered T-cells targeting the E7 protein on HPV16-positive tumor cells. The drug is currently in Phase II clinical trials for the treatment of both solid and hematological malignancies.
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Frequently Asked Questions (FAQs):
- How does TCR therapy work?
A: TCR therapy works by extracting T-cells from a patient, genetically engineering them to express specific T-cell receptors (TCRs) that can recognize cancer-associated antigens, and then reinfusing these modified T-cells back into the patient. These engineered T-cells then target and kill cancer cells displaying the specific antigen.
- What are the risks and side effects of TCR therapy?
A: Common risks and side effects of TCR therapy include cytokine release syndrome (CRS), neurotoxicity, and potential off-target effects that might damage healthy tissues. These side effects necessitate careful monitoring and management during and after treatment.
- How is TCR therapy different from CAR-T therapy?
A: While both TCR and CAR-T therapies involve genetically modifying T-cells, they differ in their target recognition mechanisms. CAR-T-cells recognize surface antigens on cancer cells through chimeric antigen receptors, whereas TCR therapy targets intracellular antigens presented by MHC molecules. This allows TCR therapy to target a broader range of cancer-associated proteins.
TABLE OF CONTENTS
1. INTRODUCTION TO THE REPORT
2. TCR THERAPY: SUMMARY
3. OVERVIEW
- 3.1. INTRODUCTION
- 3.2. STRUCTURAL CHARACTERISTICS OF THE TCR
- 3.3. TCR DIVERSITY IN THE PRE-SELECTION REPERTOIRE
- 3.4. TCR DIVERSITY IN THE NAIVE POOL
- 3.5. TCR DIVERSITY IN HEALTH AND DISEASE
- 3.6. TCR CLONOTYPES AS MARKERS OF DISEASE
- 3.7. THE TCR COMPLEX
- 3.8. TCR CO-RECEPTORS
- 3.9. ASSOCIATED MOLECULES OF THE TCR COMPLEX INVOLVED IN T-CELL ACTIVATION
- 3.10. T-CELL RECEPTOR-ENGINEERED T-CELLS FOR CANCER TREATMENT: CURRENT STATUS AND FUTURE DIRECTIONS
- 3.11. IDENTIFICATION OF TCR SEQUENCES
- 3.12. IMPROVING THE FUNCTION OF TCR-ENGINEERED T-CELLS IN TUMOR MICROENVIRONMENT
4. MARKET DYNAMICS
- 4.1. KEY DRIVERS
- 4.1.1. GROWING NUMBER OF PROMISING CLINICAL AND PRECLINICAL STUDIES
- 4.1.2. RISING CANCER INCIDENCE RATES
- 4.1.3. SURGE IN INNOVATION AND RESEARCH ACTIVITIES
- 4.2. KEY RESTRAINTS
- 4.2.1. TOXICITY FROM CYTOKINE STORMS IN TCR THERAPY
- 4.2.2. OFF-TARGET EFFECTS AND SAFETY CONCERNS IN TCR GENE TRANSFER
- 4.2.3. CHALLENGES IN SELECTING THE OPTIMAL TARGET ANTIGEN
5. PIPELINE THERAPEUTICS
- 5.1. CURRENT PIPELINE OVERVIEW
- 5.2. COMPARATIVE ANALYSIS: PRODUCTS IN VARIOUS PHASES
6. THERAPEUTIC ASSESSMENT: ACTIVE PRODUCTS
- 6.1. EVALUATION BY ROUTE OF ADMINISTRATION
- 6.2. EVALUATION BY STAGE AND ROUTE OF ADMINISTRATION
- 6.3. EVALUATION BY MOLECULE TYPE
- 6.4. EVALUATION BY STAGE AND MOLECULE TYPE
- 6.5. EVALUATION BY PRODUCT TYPE
- 6.6. EVALUATION BY STAGE AND PRODUCT TYPE
- 6.7. EVALUATION BY THERAPY AREA
- 6.8. EVALUATION BY STAGE AND THERAPY AREA
7. LATE-STAGE PRODUCTS (PRE-REGISTRATION)
- 7.1. COMPARATIVE ANALYSIS
- 7.2. ADP-A2M4: ADAPTIMMUNE
- 7.2.1. PRODUCT DESCRIPTION
- 7.2.2. RESEARCH AND DEVELOPMENT
- 7.2.3. SAFETY AND EFFICACY
- 7.2.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
8. LATE-STAGE PRODUCTS (PHASE III)
- 8.1. COMPARATIVE ANALYSIS
- 8.2. IMC F106C: IMMUNOCORE
- 8.2.1. PRODUCT DESCRIPTION
- 8.2.2. RESEARCH AND DEVELOPMENT
- 8.2.3. SAFETY AND EFFICACY
- 8.2.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
9. MID-STAGE PRODUCTS (PHASE II/III)
- 9.1. COMPARATIVE ANALYSIS
- 9.2. IMC-GP100: IMMUNOCORE
- 9.2.1. PRODUCT DESCRIPTION
- 9.2.2. RESEARCH AND DEVELOPMENT
- 9.2.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
10. MID-STAGE PRODUCTS (PHASE II)
- 10.1. COMPARATIVE ANALYSIS
- 10.2. TAEST 16001: GUANGDONG XIANGXUE PRECISION MEDICAL TECHNOLOGY CO LTD
- 10.2.1. PRODUCT DESCRIPTION
- 10.2.2. RESEARCH AND DEVELOPMENT
- 10.2.3. SAFETY AND EFFICACY
- 10.2.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 10.3. GSK 3377794: GLAXOSMITHKLINE
- 10.3.1. PRODUCT DESCRIPTION
- 10.3.2. RESEARCH AND DEVELOPMENT
- 10.3.3. SAFETY AND EFFICACY
- 10.3.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 10.4. ALT-801: ALTIMMUNE
- 10.4.1. PRODUCT DESCRIPTION
- 10.4.2. RESEARCH AND DEVELOPMENT
- 10.4.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 10.5. KITE-439: GILEAD SCIENCES
- 10.5.1. PRODUCT DESCRIPTION
- 10.5.2. RESEARCH AND DEVELOPMENT
- 10.5.3. SAFETY AND EFFICACY
- 10.5.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 10.6. KITE-718: GILEAD SCIENCES
- 10.6.1. PRODUCT DESCRIPTION
- 10.6.2. RESEARCH AND DEVELOPMENT
- 10.6.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
11. EARLY-STAGE PRODUCTS (PHASE I/II)
- 11.1. COMPARATIVE ANALYSIS
- 11.2. TC-510: ADAPTIMMUNE
- 11.2.1. PRODUCT DESCRIPTION
- 11.2.2. RESEARCH AND DEVELOPMENT
- 11.2.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.3. TCR-T LIBRARY: ALAUNOS THERAPEUTICS INC
- 11.3.1. PRODUCT DESCRIPTION
- 11.3.2. RESEARCH AND DEVELOPMENT
- 11.3.3. SAFETY AND EFFICACY
- 11.3.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.4. SCG101: SCG CELL THERAPY
- 11.4.1. PRODUCT DESCRIPTION
- 11.4.2. RESEARCH AND DEVELOPMENT
- 11.4.3. SAFETY AND EFFICACY
- 11.5. TK-8001: T-KNIFE GMBH
- 11.5.1. PRODUCT DESCRIPTION
- 11.5.2. RESEARCH AND DEVELOPMENT
- 11.5.3. SAFETY AND EFFICACY
- 11.5.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.6. ECT 204: JW THERAPEUTICS
- 11.6.1. PRODUCT DESCRIPTION
- 11.6.2. RESEARCH AND DEVELOPMENT
- 11.6.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.7. JWATM 203: JW THERAPEUTICS
- 11.7.1. PRODUCT DESCRIPTION
- 11.7.2. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.8. IMC I109V: IMMUNOCORE
- 11.8.1. PRODUCT DESCRIPTION
- 11.8.2. RESEARCH AND DEVELOPMENT
- 11.8.3. SAFETY AND EFFICACY
- 11.8.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.9. IMCM113V: IMMUNOCORE
- 11.9.1. PRODUCT DESCRIPTION
- 11.9.2. SAFETY AND EFFICACY
- 11.9.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.10. MDG 1011: MEDIGENE AG
- 11.10.1. PRODUCT DESCRIPTION
- 11.10.2. SAFETY AND EFFICACY
- 11.10.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.11. TC-210: ADAPTIMMUNE THERAPEUTICS
- 11.11.1. PRODUCT DESCRIPTION
- 11.11.2. RESEARCH AND DEVELOPMENT
- 11.11.3. SAFETY AND EFFICACY
- 11.11.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 11.12. TC-110: ADAPTIMMUNE THERAPEUTICS
- 11.12.1. PRODUCT DESCRIPTION
- 11.12.2. RESEARCH AND DEVELOPMENT
- 11.12.3. SAFETY AND EFFICACY
12. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 12.1. TBI 1301: TAKARA BIO
- 12.1.1. PRODUCT DESCRIPTION
- 12.1.2. RESEARCH AND DEVELOPMENT
- 12.1.3. SAFETY AND EFFICACY
- 12.1.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 12.2. IMA402: IMMATICS
- 12.2.1. PRODUCT DESCRIPTION
- 12.2.2. RESEARCH AND DEVELOPMENT
- 12.2.3. SAFETY AND EFFICACY
- 12.2.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 12.3. TAC01 HER2: TRIUMVIRA
- 12.3.1. PRODUCT DESCRIPTION
- 12.3.2. RESEARCH AND DEVELOPMENT
- 12.3.3. SAFETY AND EFFICACY
- 12.4. TAC01 CLDN18.2: TRIUMVIRA
- 12.4.1. PRODUCT DESCRIPTION
- 12.4.2. RESEARCH AND DEVELOPMENT
- 12.4.3. SAFETY AND EFFICACY
- 12.5. HBV ANTIGEN SPECIFIC TCR REDIRECTED T-CELL: LION TCR
- 12.5.1. PRODUCT DESCRIPTION
- 12.5.2. RESEARCH AND DEVELOPMENT
- 12.5.3. SAFETY AND EFFICACY
- 12.5.4. PRODUCT AND DEVELOPMENTAL ACTIVITIES
- 12.6. TC-E202: TCRCURE BIOTECH
- 12.6.1. PRODUCT DESCRIPTION
- 12.6.2. RESEARCH AND DEVELOPMENT
- 12.6.3. PRODUCT AND DEVELOPMENTAL ACTIVITIES
13. EARLY-STAGE PRODUCTS (PHASE I)
- 13.1. COMPARATIVE ANALYSIS
- 13.2. TSC-100: TSCAN THERAPEUTICS
- 13.2.1. PRODUCT DESCRIPTION
- 13.2.2. RESEARCH AND DEVELOPMENT
- 13.2.3. SAFETY AND EFFICACY
- 13.3. TSC-200: TSCAN THERAPEUTICS
- 13.3.1. PRODUCT DESCRIPTION
- 13.3.2. RESEARCH AND DEVELOPMENT
- 13.4. IMA201: IMMATICS
- 13.4.1. PRODUCT DESCRIPTION
- 13.4.2. RESEARCH AND DEVELOPMENT
- 13.5. IMA203: IMMATICS
- 13.5.1. PRODUCT DESCRIPTION
- 13.5.2. RESEARCH AND DEVELOPMENT
- 13.5.3. SAFETY AND EFFICACY
- 13.6. ADP-A2M10: ADAPTIMMUNE
- 13.6.1. PRODUCT DESCRIPTION
- 13.6.2. RESEARCH AND DEVELOPMENT
- 13.6.3. SAFETY AND EFFICACY
- 13.6.4. PRODUCT DEVELOPMENTAL ACTIVITY
- 13.7. ADP-A2AFP: ADAPTIMMUNE
- 13.7.1. PRODUCT DESCRIPTION
- 13.7.2. RESEARCH AND DEVELOPMENT
- 13.7.3. SAFETY AND EFFICACY
- 13.7.4. PRODUCT DEVELOPMENTAL ACTIVITY
- 13.8. CMV TCR-T: CHINA IMMUNOTECH
- 13.8.1. PRODUCT DESCRIPTION
- 13.8.2. RESEARCH AND DEVELOPMENT
- 13.8.3. SAFETY AND EFFICACY
- 13.9. IMA401: IMMATICS
- 13.9.1. PRODUCT DESCRIPTION
- 13.9.2. RESEARCH AND DEVELOPMENT
- 13.9.3. SAFETY AND EFFICACY
- 13.9.4. PRODUCT DEVELOPMENTAL ACTIVITIES
- 13.10. BNT221: BIONTECH
- 13.10.1. PRODUCT DESCRIPTION
- 13.10.2. RESEARCH AND DEVELOPMENT
- 13.10.3. SAFETY AND EFFICACY
- 13.11. NT 125: NEOGENE THERAPEUTICS
- 13.11.1. PRODUCT DESCRIPTION
- 13.11.2. PRODUCT DEVELOPMENTAL ACTIVITIES
- 13.12. NT-175: NEOGENE THERAPEUTICS
- 13.12.1. PRODUCT DESCRIPTION
- 13.12.2. RESEARCH AND DEVELOPMENT
- 13.12.3. PRODUCT DEVELOPMENTAL ACTIVITIES
- 13.13. LYL-845: LYELL IMMUNOPHARMA
- 13.13.1. PRODUCT DESCRIPTION
- 13.13.2. RESEARCH AND DEVELOPMENT
- 13.14. BRL03: BIOSYNGEN
- 13.14.1. PRODUCT DESCRIPTION
- 13.15. TSC 101: TSCAN THERAPEUTICS
- 13.15.1. PRODUCT DESCRIPTION
- 13.15.2. RESEARCH AND DEVELOPMENT
- 13.15.3. SAFETY AND EFFICACY
- 13.16. AB-1015: ARSENALBIO
- 13.16.1. PRODUCT DESCRIPTION
- 13.16.2. RESEARCH AND DEVELOPMENT
- 13.16.3. SAFETY AND EFFICACY
- 13.17. TSC 204: TSCAN THERAPEUTICS
- 13.17.1. PRODUCT DESCRIPTION
- 13.17.2. RESEARCH AND DEVELOPMENT
- 13.18. TSC 203: TSCAN THERAPEUTICS
- 13.18.1. PRODUCT DESCRIPTION
- 13.18.2. PRODUCT DEVELOPMENTAL ACTIVITY
- 13.19. 800 TCR: T-CURE
- 13.19.1. PRODUCT DESCRIPTION
- 13.19.2. RESEARCH AND DEVELOPMENT
- 13.19.3. PRODUCT DEVELOPMENTAL ACTIVITY
- 13.20. 820 TCR: T-CURE
- 13.20.1. PRODUCT DESCRIPTION
- 13.20.2. RESEARCH AND DEVELOPMENT
14. IND-STAGE PRODUCTS
- 14.1. COMPARATIVE ANALYSIS
15. PRECLINICAL-STAGE PRODUCTS
- 15.1. COMPARATIVE ANALYSIS
16. DISCOVERY-STAGE PRODUCTS
- 16.1. COMPARATIVE ANALYSIS
17. INACTIVE PRODUCTS
- 17.1. COMPARATIVE ANALYSIS
18. STRATEGIC DEVELOPMENTS
- 18.1. MERGERS & ACQUISITIONS
- 18.2. PARTNERSHIPS & AGREEMENTS
19. UNMET NEEDS
LIST OF TABLES
- TABLE 1: TOTAL ACTIVE PRODUCTS IN THE TCR THERAPY PIPELINE
- TABLE 2: PRODUCTS IN VARIOUS PHASES
- TABLE 3: EVALUATION BY ROUTE OF ADMINISTRATION
- TABLE 4: EVALUATION BY MOLECULE TYPE
- TABLE 5: EVALUATION BY PRODUCT TYPE
- TABLE 6: EVALUATION BY THERAPY AREA
- TABLE 7: LATE-STAGE PRODUCTS (PRE-REGISTRATION)
- TABLE 8: CLINICAL TRIALS DESCRIPTION: ADP-A2M4
- TABLE 9: GENERAL DESCRIPTION: ADP-A2M4
- TABLE 10: LATE-STAGE PRODUCTS (PHASE III)
- TABLE 11: CLINICAL TRIALS DESCRIPTION: IMC-F106C
- TABLE 12: GENERAL DESCRIPTION: IMC-F106C
- TABLE 13: MID-STAGE PRODUCTS (PHASE II/III)
- TABLE 14: CLINICAL TRIALS DESCRIPTION: IMCGP100
- TABLE 15: GENERAL DESCRIPTION: IMCGP100
- TABLE 16: MID-STAGE PRODUCTS (PHASE II)
- TABLE 17: CLINICAL TRIALS DESCRIPTION
- TABLE 18: GENERAL DESCRIPTION: TAEST 16001
- TABLE 19: CLINICAL TRIALS DESCRIPTION: GSK 3377794
- TABLE 20: GENERAL DESCRIPTION: GSK 3377794
- TABLE 21: CLINICAL TRIALS DESCRIPTION: ALT-801
- TABLE 22: GENERAL DESCRIPTION: ALT-801
- TABLE 23: CLINICAL TRIALS DESCRIPTION: KITE-439
- TABLE 24: GENERAL DESCRIPTION: KITE-439
- TABLE 25: CLINICAL TRIALS DESCRIPTION: KITE-718
- TABLE 26: GENERAL DESCRIPTION: KITE-718
- TABLE 27: EARLY-STAGE PRODUCTS (PHASE I/II)
- TABLE 28: CLINICAL TRIALS DESCRIPTION: TC-510
- TABLE 29: GENERAL DESCRIPTION: TC-510
- TABLE 30: CLINICAL TRIALS DESCRIPTION: TCR-T LIBRARY
- TABLE 31: GENERAL DESCRIPTION: TCR-T LIBRARY
- TABLE 32: CLINICAL TRIALS DESCRIPTION: SCG101
- TABLE 33: GENERAL DESCRIPTION: SCG101
- TABLE 34: CLINICAL TRIALS DESCRIPTION: TK-8001
- TABLE 35: GENERAL DESCRIPTION: TK-8001
- TABLE 36: CLINICAL TRIALS DESCRIPTION: ECT204
- TABLE 37: GENERAL DESCRIPTION: ECT204
- TABLE 38: GENERAL DESCRIPTION: JWATM 203
- TABLE 39: CLINICAL TRIALS DESCRIPTION: IMC-I109V
- TABLE 40: GENERAL DESCRIPTION: IMC-I109V
- TABLE 41: GENERAL DESCRIPTION: IMC M113V
- TABLE 42: GENERAL DESCRIPTION: MDG 1011
- TABLE 43: CLINICAL TRIALS DESCRIPTION: TC-210
- TABLE 44: GENERAL DESCRIPTION: TC-210
- TABLE 45: CLINICAL TRIALS DESCRIPTION: TC-110
- TABLE 46: GENERAL DESCRIPTION: TC-110
- TABLE 47: CLINICAL TRIALS DESCRIPTION: TBI 1301
- TABLE 48: GENERAL DESCRIPTION: TBI 1301
- TABLE 49: CLINICAL TRIALS DESCRIPTION: IMA402
- TABLE 50: GENERAL DESCRIPTION: IMA402
- TABLE 51: CLINICAL TRIALS DESCRIPTION: TAC01 HER2
- TABLE 52: GENERAL DESCRIPTION: TAC01 HER2
- TABLE 53: CLINICAL TRIALS DESCRIPTION: TAC01 CLDN18.2
- TABLE 54: GENERAL DESCRIPTION: TAC01 CLDN18.2
- TABLE 55: CLINICAL TRIALS DESCRIPTION: HBV ANTIGEN SPECIFIC TCR REDIRECTED T-CELL
- TABLE 56: GENERAL DESCRIPTION: HBV ANTIGEN SPECIFIC TCR REDIRECTED T-CELL
- TABLE 57: CLINICAL TRIALS DESCRIPTION: TC-E202
- TABLE 58: GENERAL DESCRIPTION: TC-E202
- TABLE 59: EARLY-STAGE PRODUCTS (PHASE I)
- TABLE 60: CLINICAL TRIALS DESCRIPTION: TSC-100
- TABLE 61: GENERAL DESCRIPTION: TSC-100
- TABLE 62: CLINICAL TRIALS DESCRIPTION: TSC-200
- TABLE 63: GENERAL DESCRIPTION: TSC-200
- TABLE 64: CLINICAL TRIALS DESCRIPTION: IMA201
- TABLE 65: GENERAL DESCRIPTION: IMA201
- TABLE 66: CLINICAL TRIALS DESCRIPTION: IMA203
- TABLE 67: GENERAL DESCRIPTION: IMA203
- TABLE 68: CLINICAL TRIALS DESCRIPTION: ADP-A2M10
- TABLE 69: GENERAL DESCRIPTION: ADP-A2M10
- TABLE 70: CLINICAL TRIALS DESCRIPTION: ADP-A2AFP
- TABLE 71: GENERAL DESCRIPTION: ADP-A2AFP
- TABLE 72: CLINICAL TRIALS DESCRIPTION: CMV-TCR-T
- TABLE 73: GENERAL DESCRIPTION: CMV-TCR-T
- TABLE 74: CLINICAL TRIALS DESCRIPTION: IMA401
- TABLE 75: GENERAL DESCRIPTION: IMA401
- TABLE 76: CLINICAL TRIALS DESCRIPTION: BNT221
- TABLE 77: GENERAL DESCRIPTION: BNT221
- TABLE 78: GENERAL DESCRIPTION: NT-125
- TABLE 79: CLINICAL TRIALS DESCRIPTION: NT-175
- TABLE 80: GENERAL DESCRIPTION: NT-175
- TABLE 81: CLINICAL TRIALS DESCRIPTION: LYL845
- TABLE 82: GENERAL DESCRIPTION: LYL845
- TABLE 83: GENERAL DESCRIPTION: BRL03
- TABLE 84: CLINICAL TRIALS DESCRIPTION: TSC-101
- TABLE 85: GENERAL DESCRIPTION: TSC-101
- TABLE 86: CLINICAL TRIALS DESCRIPTION: AB-1015
- TABLE 87: GENERAL DESCRIPTION: AB-1015
- TABLE 88: CLINICAL TRIALS DESCRIPTION: TSC-204
- TABLE 89: GENERAL DESCRIPTION: TSC-204
- TABLE 90: GENERAL DESCRIPTION: TSC-203
- TABLE 91: CLINICAL TRIALS DESCRIPTION: 800 TCR
- TABLE 92: GENERAL DESCRIPTION: 800 TCR
- TABLE 93: CLINICAL TRIALS DESCRIPTION: 820 TCR
- TABLE 94: GENERAL DESCRIPTION: 820 TCR
- TABLE 95: IND-STAGE PRODUCTS
- TABLE 96: PRECLINICAL-STAGE PRODUCTS
- TABLE 97: DISCOVERY-STAGE PRODUCTS
- TABLE 98: INACTIVE-STAGE PRODUCTS
- TABLE 99: LIST OF MERGERS & ACQUISITIONS
- TABLE 100: LIST OF PARTNERSHIPS & AGREEMENTS
LIST OF FIGURES
- FIGURE 1: TCR PROTEIN AND GENE STRUCTURE
- FIGURE 2: GENE REARRANGEMENT AT THE TR LOCI
- FIGURE 3: SIZE AND COMPOSITION OF THE PRE-SELECTION, NAIVE AND ANTIGEN-EXPERIENCED REPERTOIRES
- FIGURE 4: SKEWING OF THE TCR REPERTOIRE IN HUMAN DISEASE
- FIGURE 5: PROCESS OF TCR-ENGINEERED T-CELLS THERAPY
- FIGURE 6: TCR SIGNALING
- FIGURE 7: THREE TYPICAL PROCEDURES TO OBTAIN TCR SEQUENCE
- FIGURE 8: PRODUCTS IN VARIOUS PHASES
- FIGURE 9: EVALUATION BY ROUTE OF ADMINISTRATION
- FIGURE 10: EVALUATION BY STAGE AND ROUTE OF ADMINISTRATION
- FIGURE 11: EVALUATION BY MOLECULE TYPE
- FIGURE 12: EVALUATION BY STAGE AND MOLECULE TYPE
- FIGURE 13: EVALUATION BY PRODUCT TYPE
- FIGURE 14: EVALUATION BY STAGE AND PRODUCT TYPE
- FIGURE 15: EVALUATION BY THERAPY AREA
- FIGURE 16: EVALUATION BY STAGE AND THERAPY AREA
- FIGURE 17: LATE-STAGE PRODUCTS (PRE-REGISTRATION)
- FIGURE 18: LATE-STAGE PRODUCTS (PHASE III)
- FIGURE 19: MID-STAGE PRODUCTS (PHASE II/III)
- FIGURE 20: MID-STAGE PRODUCTS (PHASE II)
- FIGURE 21: EARLY-STAGE PRODUCTS (PHASE I/II)
- FIGURE 22: EARLY-STAGE PRODUCTS (PHASE I)
- FIGURE 23: IND-STAGE PRODUCTS
- FIGURE 24: PRECLINICAL-STAGE PRODUCTS
- FIGURE 25: DISCOVERY-STAGE PRODUCTS
- FIGURE 26: INACTIVE STAGE PRODUCTS
