Therapeutic Anti-Inflammatory Drugs & Markets: Targets, Technologies, Markets, Strategies, Forecasts

Mediating the Inflammatory Cascade

The influence of immune mediators on inflammatory diseases has put the immune mediated therapeutics at the center of inflammatory disease treatment and management. The result is a growing list of approved and development-stage drugs designed to inhibit at least one of the fifteen pathway targets that drive the transcription and secretion of inflammatory cytokines into the extracellular space where they impact patient morbidity and inflammatory disease burden. The competitive landscape now includes more than two dozen drug developers. As this marketspace has evolved, the prime product opportunities, which we define as the drugability of individual pathway targets factored by the inverse of the number of competing drugs and late-stage candidates, has been shrinking. The distribution of therapeutic products in this segment varies across pathway elements, with 84 percent targeting signaling proteins and ligands, and receptors and transcription factors accounting for 8 percent each.

Targeting Key Inflammatory Pathways:

The identification of key immune mechanisms as causative for human inflammatory disease has led to the approval and rapid development of novel therapeutic agents.

Monoclonal antibodies to a variety of cytokines and cytokine receptors and small-molecule inhibitors of RORyt and JAKs are changing the therapeutic landscape, with three dozen distinct products now approved or in clinical development.

Humanized monoclonal antibodies to both IL-17 and IL-17RA are enabling improved outcomes for moderate to severe psoriasis as well as psoriatic arthritis.

What You Will Learn:

• What are the immune factors that are responsible for immune mediated inflammatory Diseases?

• What are the inflammatory-mediated ligands, receptors, signaling proteins and transcription factors that represent druggable targets?

• What are the major factors driving the high level of development activity in immune mediated inflammatory diseases?

• What is the size of the market today, who are the market share leaders?

• What will be the effects of competing pathway solutions for the same indication and how will this dynamic impact revenue forecasts over the next four years?

• What are the significant economic, technology, and regulatory factors affecting the market for immune therapeutics?