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PUBLISHER: GlobalData | PRODUCT CODE: 1689307

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PUBLISHER: GlobalData | PRODUCT CODE: 1689307

Innovation Insights: Cell Therapy for Autoimmune diseases

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PAGES: 50 Pages
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Cell therapy for autoimmune diseases involves using various types of cells, such as mesenchymal stem cells or regulatory T cells, to modulate the immune system and reduce inflammation in patients with autoimmune disorders. These cells are often derived from the patient's own body or from a donor and are administered through injections or infusions. The goal of cell therapy is to restore immune balance and tolerance, ultimately leading to a reduction in disease symptoms and progression. While still in the early stages of research and development, cell therapy shows promise as a potential treatment option for a wide range of autoimmune diseases, including rheumatoid arthritis, multiple sclerosis, and lupus. Further clinical trials and studies are needed to fully understand the effectiveness and safety of cell therapy for autoimmune diseases.

Cell therapies for autoimmune diseases utilize stem cells such as iPSCs, MSCs, HPSCs, or programmed immune cells like T-cells, natural killer cells, or dendritic cells of allogenic or autologous origin. This innovation is considered a medium-impact innovation in the near term among the 15 key innovation areas. Patent analysis shows a significant growth in CAR-T cell-based treatments, which could impact the field in the coming years.

The majority of patenting activity is led by small biotech companies and universities, with less participation from big pharma. While there has been an overall increasing trend in patent filings, there was a slight dip in 2023. Graft v. Host Disease and Multiple Sclerosis are the top indications mentioned in patents, with 56% of recent patents focusing on the use of CAR-T cells or genetically modified immune cells for treating autoimmune diseases.

Leading patent filers include Fate Therapeutics, Vertex, and Bristol-Myers Squibb, with big pharma companies acquiring key innovating companies to build their innovation portfolios in this area. The US, Europe, and Japan are the main regions for patenting activity, with China showing growth driven by small biotech companies.

In the startup ecosystem, over 50 startups are identified and ranked, with companies like Mozart Therapeutics, Magenta Therapeutics, and Kyverna leading the way. Magenta has reportedly halted its autoimmune therapy development program.

The drug landscape for Cell Therapy for Autoimmune Disease includes 267 drugs, primarily focusing on Immunology and Oncology therapies. Intravenous administration is the most common route for drug delivery. Major players like Sangamo Therapeutics Inc and Cartesian Therapeutics Inc are advancing drug development, particularly in Preclinical and Phase I trials, indicating a maturing pipeline with potential market entry in the near future.

There are 539 clinical trials for Cell Therapy for Autoimmune Disease drugs, with top sponsors being Foundation for Orthopaedics and Regenerative Medicine and Hope Biosciences Stem Cell Research Foundation. Oncology trials dominate, with Systemic Lupus Erythematosus being the top indication.

In terms of deals, there have been 298 deals totaling $34.10 billion, with the United States leading in M&A deals. The highest deal volume was in 2020, while the highest deal value was in 2022. The decline in 2023 and slight decrease in 2024 may indicate market adjustments and strategic consolidations, with the United States being the major geography for deals.

How is our 'State of Innovation intelligence 2024' report unique from other reports in the market?

Our "Cell Therapy for Autoimmune Diseases" report is uniquely positioned in the market because:

Integrated Data Ecosystem: Unlike many reports that focus on a single aspect, our report consolidates patents, drugs, clinical trials, and deals data, offering a 360° view of the cell therapy landscape specifically for autoimmune diseases.

Niche Focus with Depth: While broader cell therapy reports exist, our report hones in on autoimmune diseases, delivering deep, targeted insights that address the unique challenges and opportunities in this niche.

Advanced Analytics and Actionable Insights: We employ state-of-the-art analytics and visualizations, transforming complex data into clear, strategic intelligence to support informed decision-making.

Strategic Market Positioning: By detailing competitive dynamics, investment trends, and regulatory developments, our report empowers biopharma companies, investors, and researchers to stay ahead of market shifts.

We recommend this valuable source of information to anyone involved in -

Drug Development and Pharma/Biotech Companies - Value chain

Pharmaceutical Industry Suppliers and Distributors

Pharma/Drug Manufacturing Companies - Leaders and Startups

Business Development and Market Intelligence

Investment Analysts and Portfolio Managers

Professional Services - Investment Banks, PE/VC Firms

M&A/Investment, Management Consultants, and Consulting Firms

Key Highlights

  • Cell Therapy for Autoimmune Diseases report is a high-impact innovation area in the Pharma industry, with a growing number of patents being filed and a focus on new indications such as Autoimmune g diseases.
  • Big pharma companies like BMS and co dominate the patent activity in Cell Therapy for Autoimmune Diseases with a dip in new companies filing patents in recent years.
  • Competitive intelligence shows that sana biotech and Fate Ther in terms of portfolio size are among the leaders with strong innovation portfolios in Cell Therapy for Autoimmune Diseases.
  • Startups like Mozart and Abelzeta are leading in terms of innovation impact and focus in the Cell Therapy for Autoimmune Diseases.
  • The drug landscape for Cell Therapy for Autoimmune Diseases is dominated by innovator drugs, with a focus on Immunology and Oncology, and major players like Sangamo Therapeutics and Cartesian Therapeutics leading in drug development.
  • Clinical trials in Cell Therapy for Autoimmune Diseases are dominated by Oncology trials, with the Foundation for Orthopedics and Regenerative Medicine leading in the number of trials.

Scope

  • Innovation Insights: innovation examples by each use cases segment of various sectors to present key trends.
  • Key player: This represents a sample list of key players in each use case highlighted in the report.
  • Startups: This represents a sample list of emerging starups in each use case highlighted in the report.
  • University: This represents a sample list of leading universities in each use case highlighted in the report.

Reasons to Buy

Comprehensive Market Intelligence -

  • The report integrates patents, drugs, clinical trials, and deals data, providing a holistic view of the latest advancements in cell therapy for autoimmune diseases.

Competitive Benchmarking -

  • Identify leading companies, emerging startups, and research institutions driving innovation in this space, helping you stay ahead of competitors.

Strategic R&D Insights -

  • Gain actionable insights into promising therapies, clinical trial trends, and novel mechanisms to refine your R&D pipeline and accelerate drug development.

Investment & Partnership Opportunities -

  • Discover licensing, M&A, and collaboration opportunities by analyzing funding trends, strategic alliances, and key deals in the market.

Regulatory & Intellectual Property Landscape -

  • Understand the evolving regulatory frameworks and patent trends to mitigate risks and enhance IP and market entry strategies.
Product Code: GDPD-HI-P0007

Table of Contents

Table of Contents

1. Innovation Insights

  • 1.1 Innovation radar
  • 1.2 Innovation s-curve
  • 1.3 Innovation deep dive
  • 1.4 Innovation deep dive - trending indications
  • 1.5 Top companies Based on portfolio strength and temporal indicators

2. Competitive Insights

  • 2.1 Key innovation leaders - big pharma
  • 2.2.Key innovators - startups and small biotech
  • 2.3 Key innovations - Universities and research institutions
  • 2.4 Most cited patents
  • 2.5 Insights from AI hub

3.Market Insights

  • 3.1 Drugs
    • 3.1.1 Key Players
    • 3.1.2 Route of administration & drug type
    • 3.1.3 Top therapy area & indication
  • 3.2 Clinical Trials
    • 3.2.1 Key Sponsors
    • 3.2.2 Key development stages
  • 3.3 Deals
    • 3.3.1. Key Acquirers
    • 3.3.2 Deal type distribution
    • 3.3.3 Geographical distribution
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Jeroen Van Heghe

Manager - EMEA

+32-2-535-7543

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Christine Sirois

Manager - Americas

+1-860-674-8796

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