PUBLISHER: GlobalData | PRODUCT CODE: 1489995
PUBLISHER: GlobalData | PRODUCT CODE: 1489995
This report covers the 8MM (US, France, Germany, Italy, Spain, UK, Japan, China) and provides an Excel-based forecast model for the bronchiectasis market through 2033.
Bronchiectasis, which has been given diagnostic code of J47.9 from the International Classification of Diseases, Tenth Edition (ICD-10), is defined by damage to the bronchi, causing abnormal dilation and scarring. The airways become inflamed with thick mucus that is difficult to clear, which build-up creates an environment for bacterial growth; uncontrolled bacterial growth leads to frequent infections. The cycle of repeated infections can in turn cause further damage to the airways. Bronchiectasis can occur throughout the lung or in a single section of lung.
Bronchiectasis is split into two main types: cystic fibrosis (CF), a genetically inherited disorder affecting the lungs, and non-CF bronchiectasis. Individuals who have CF can have lung symptoms similar to those of bronchiectasis, but for the purposes of this report, only non-CF bronchiectasis will be discussed. Some patients are symptom-free in everyday life and become clinically conspicuous only during exacerbations. Symptoms include excessive coughing (can be dry or productive, although productive cough is more common, especially in more severe/advanced disease), sputum production, recurrent chest infections, malaise, chest discomfort, hemoptysis, and weight loss.
Bronchiectasis is still relatively poorly understood; increasing emphasis has been placed on the role of underlying factors, such as the presence of comorbidities, but the development of bronchiectasis is multifactorial. Contributing factors include infections, immunodeficiency, impaired mucociliary clearance, previous lung injury, airway lesions, concurrent chronic respiratory diseases, and connective tissue and/or autoimmune diseases (Chalmers et al., 2018). There are no therapies marketed for the treatment of bronchiectasis, so there is a high demand due to the large unmet need
GlobalData projects the global bronchiectasis marketplace - which, for the purposes of this report, comprises eight major pharmaceutical markets (US, France, Germany, Italy, Spain, UK, Japan, China) - to experience a significant growth during the forecast period. This growth will be driven primarily by the increase in the diagnosed cases, as well as by the global launch of Insmed's dipeptidyl peptidase-1 (DPP-1) inhibitor brensocatib, subject to approval. Nevertheless, drug-class preference by patients and physicians, are expected to curtail market growth, as the current management of bronchiectasis relies on generic off-label therapies.
This model covers the market forecast for marketed and late-stage pipeline for insomnia treatment. The base year of this model is 2023, and the forecast period is 2023-2033.