Global Vascular Endothelial Growth Factor Receptor (VEGFR) Inhibitors Market - 2025-2033

The global vascular endothelial growth factor receptor (VEGFR) inhibitors market reached US$ 14.12 billion in 2024 and is expected to reach US$ 22.34 billion by 2033, growing at a CAGR of 5.9 % during the forecast period of 2025-2033.

Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) inhibitors are therapeutic agents that block the activity of VEGF and VEGFR, which play a key role in angiogenesis, the formation of new blood vessels from existing ones. VEGF and VEGFR signaling is critical for various physiological and pathological processes, including cancer progression, degenerative eye conditions, and inflammatory diseases.

In cancer, abnormal angiogenesis facilitates tumor growth and metastasis, making VEGF/VEGFR inhibitors important in blocking these pathways. These inhibitors include monoclonal antibodies that target VEGF itself (e.g., bevacizumab) and tyrosine kinase inhibitors (TKIs) that target VEGFR (e.g., pazopanib). These drugs are widely used to treat different cancers, such as renal cell carcinoma, colorectal cancer, and hepatocellular carcinoma, among others.

Tyrosine kinase inhibitors (TKIs) are the most common VEGFR inhibitors, which block the intracellular signaling required for angiogenesis and tumor growth. Common examples include pazopanib, sunitinib, and cabozantinib. Monoclonal antibody (mAbs) inhibitors directly bind to the VEGF molecule or its receptor, preventing it from triggering angiogenesis. Drugs like bevacizumab fall into this category.

Market Dynamics: Drivers & Restraints

Rising Incidence and Prevalence of Cancer

The rising incidence and prevalence of cancer are significantly driving the growth of the global vascular endothelial growth factor receptor (VEGFR) inhibitors market and are expected to drive it throughout the market forecast period. Cancer is one of the leading causes of death worldwide, and its incidence is expected to rise due to factors such as aging populations, lifestyle changes, and environmental influences.

For instance, according to the globocon data in 2022, the cancer incidence for males was 10.3 million, while for females, it was 9.7 million. By 2025, the cancer incidence is projected to reach 12.5 million for males and 11.6 million for females. As the global cancer burden continues to increase, the demand for effective treatment options, including VEGFR inhibitors, has surged.

Additionally, key players in the industry have announced product launches and approvals that would drive this market growth. For instance, in November 2023, HUTCHMED announced that Takeda has received U.S. FDA approval for FRUZAQLA (fruquintinib) to treat metastatic colorectal cancer (mCRC) in adults who have already undergone prior chemotherapy and anti-VEGF treatment. The approval is based on data from the Phase 3 FRESCO-2 trial, which demonstrated that fruquintinib significantly improves both overall survival (OS) and progression-free survival (PFS) in patients with previously treated mCRC. All these factors demand the global vascular endothelial growth factor receptor (VEGFR) inhibitors market.

High Cost of Treatment

The high cost of treatment will hinder the growth of the global vascular endothelial growth factor receptor (VEGFR) inhibitors market. VEGFR inhibitors, including tyrosine kinase inhibitors (TKIs) and monoclonal antibodies, are among the most expensive cancer therapies due to their complex development processes, high manufacturing costs, and the specialized nature of the treatments. This financial burden is exacerbated by the long duration of treatment, especially in cancers that require ongoing management, such as renal cell carcinoma, colorectal cancer, and hepatocellular carcinoma.

A key factor contributing to the high costs is the research and development (R&D) investment needed to bring these drugs to market. For instance, drugs like Bevacizumab monotherapy had an individual treatment cost of $14,772 over 11 years, with a societal return of $357,680, resulting in an impressive 2,421% return on investment (ROI). In comparison, ranibizumab therapy cost $106,582, yielding a societal return of $265,870 (249% ROI), while aflibercept treatment cost $61,811 and generated $310,611 in societal returns (503% ROI). For the 2018 NVAMD treatment cohort, the total 11-year societal gain was estimated at $28.5 billion, with $24.2 billion (about 85%) attributed to bevacizumab, $0.7 billion (2.5%) to ranibizumab, and $3.6 billion (12.6%) to aflibercept. Thus, the above factors could be limiting the global vascular endothelial growth factor receptor (VEGFR) inhibitors market's potential growth.

Segment Analysis

The global vascular endothelial growth factor receptor (VEGFR) inhibitors market is segmented based on type, drug type, application, route of administration, and region.

Drug Type:

The tyrosine kinase inhibitor (TKI) segment in the drug type is expected to dominate the global vascular endothelial growth factor receptor (VEGFR) inhibitors market

The tyrosine kinase inhibitor (TKI) segment plays a crucial role in the global vascular endothelial growth factor receptor (VEGFR) inhibitors market, largely driven by the increasing demand for targeted cancer therapies. TKIs block VEGFR signaling, which is essential for angiogenesis, the process of forming new blood vessels that support tumor growth and metastasis. By targeting this pathway, TKIs help limit the blood supply to tumors, inhibiting their growth and spread. This has made them particularly effective in treating various cancers, such as renal cell carcinoma, colorectal cancer, and hepatocellular carcinoma.

Notable TKIs in the VEGFR inhibitor market include pazopanib, sunitinib, cabozantinib, lenvatinib, and regorafenib. These drugs are designed to specifically block VEGFR and interfere with the angiogenesis process, thereby preventing tumors from forming the blood vessels they need to grow. The TKI segment has been strengthened by strong clinical trial data, showing that these inhibitors are effective both as monotherapies and in combination with other cancer treatments. This has expanded their use across multiple cancer types, boosting their market demand.

Additionally, key players in the industry's product launches and approvals would drive this segment growth in the market. For instance, in December 2023, the U.S. Food and Drug Administration (FDA) approved belzutifan (Welireg) for the treatment of advanced renal cell carcinoma (RCC) in patients who have previously received a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor and a vascular endothelial growth factor tyrosine kinase inhibitor (VEGF-TKI). These factors have solidified the segment's position in the global vascular endothelial growth factor receptor (VEGFR) inhibitors market.

Geographical Analysis

North America is expected to hold a significant position in the global vascular endothelial growth factor receptor (VEGFR) inhibitors market share

North America holds a substantial position in the global vascular endothelial growth factor receptor (VEGFR) inhibitors market and is expected to hold most of the market share. The increasing prevalence of diseases such as cancer, which require targeted treatments to inhibit angiogenesis, is driving the growing demand for VEGFR inhibitors. These therapies, which disrupt the formation of blood vessels that support tumor growth, are becoming essential in managing various cancers, thus leading to a significant rise in their market adoption.

According to the National Institutes of Health (NIH) data in May 2024, cancer has a significant impact on society both in the United States and globally. Cancer statistics offer insight into the scope of the disease and reflect its burden on society. In 2024, it is estimated that 2,001,140 new cases of cancer will be diagnosed in the United States, and 611,720 people will succumb to the disease. The escalating incidence of cancer underscores the urgent need for VEGFR inhibitor solutions.

Both the U.S. and Canada have significantly increased their investments in healthcare research and development (R&D), which has played a pivotal role in advancing VEGFR-targeted therapies. This enhanced financial support is expected to continue driving market growth in the coming years.Furthermore, the adoption of cutting-edge medical technologies, including advanced diagnostic tools, is accelerating the use of VEGFR inhibitors. As healthcare providers increasingly incorporate these technologies into personalized treatment plans, the demand for these therapies is growing, contributing to the overall expansion of the market.

In this region, a major number of key players are present, with well-advanced healthcare infrastructure, government initiatives, and product approvals that would drive this market growth. For instance, in October 2024, Elevar Therapeutics announced the acceptance of its New Drug Application (NDA) for rivoceranib, in combination with camrelizumab, by the U.S. FDA. This combination therapy is being proposed as a first-line treatment for patients with unresectable hepatocellular carcinoma (uHCC), a form of liver cancer. Thus, the above factors are consolidating the region's position as a dominant force in the global vascular endothelial growth factor receptor (VEGFR) inhibitors market.

Competitive Landscape

The major global players in the vascular endothelial growth factor receptor (VEGFR) inhibitors market include Novartis AG, F. Hoffmann-La Roche Ltd, Amgen Inc., Pfizer Inc., Biocon, Exelixis, Inc., Bayer AG, Eisai Co., Ltd., Takeda Pharmaceuticals U.S.A., Inc., Sanofi (Regeneron Pharmaceuticals, Inc.), AVEO Pharmaceuticals, Inc., Eli Lilly and Company, and Genentech USA, Inc. among others.

Key Developments

• In September 2024, Takeda received approval in Japan for FRUZAQLA (fruquintinib) to treat unresectable advanced or recurrent colorectal cancer (CRC). This approval was granted by the Japanese Ministry of Health, Labour and Welfare (MHLW) and is based on results from the FRESCO-2 global Phase 3 trial.

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• Post-market Surveillance: Uses post-market data to enhance product safety and access.
• Pharmacoeconomics & Value-Based Pricing: Analyzes the shift to value-based pricing and data-driven decision-making in R&D.

The global vascular endothelial growth factor receptor (VEGFR) inhibitors market report delivers a detailed analysis with 60+ key tables, more than 50 visually impactful figures, and 176 pages of expert insights, providing a complete view of the market landscape.

Target Audience 2024

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