Global Orthobiologics Market - 2024-2032

The global orthobiologics market reached US$5.26 billion in 2023 and is expected to reach US$7.85 billion by 2032, growing at a CAGR of 4.6% during the forecast period 2024-2032.

Orthobiologics are therapies that originate from biological sources and are aimed at treating orthopedic conditions. Orthobiologics sometimes referred to as regenerative therapies are painless alternatives to surgical procedures. They help reduce the pain, accelerate healing, and improve the overall recovery of the patient. The most commonly used orthobiologics include platelet-rich plasma, autografts, allografts, bone morphogenetic proteins, demineralized bone matrix, marrow concentrates, stem cells, and viscosupplements.

These novel therapies are used in orthopedic conditions and procedures like osteoarthritis, spinal fusion surgery, trauma surgery, reconstructive surgery, sports injuries, etc. Since these therapies are relatively new, the majority of them lack proper clinical evidence studies to validate their efficacy in different population groups. However, with the burgeoning research, and rising prevalence of orthopedic conditions, the market is expected to grow in the mid-single digit CAGR.

Market Dynamics: Drivers & Restraints

Rising prevalence of orthopedic conditions

Orthobiologics are the designated therapies for several orthopedic conditions such as osteoarthritis, traumatic injuries, spinal injuries, bone fractures, etc. Due to their novelty, and non-invasive nature, their demand has been rising for the past decade. These are the newer therapies in orthopedics, and as they promote regeneration and quick healing, they are gaining huge importance and are being integrated into the standard of care.

Moreover, with the growing elderly population worldwide, the prevalence of several orthopedic conditions is rising across the globe. This rising patient population is a significant opportunity for orthobiologics market expansion.

For instance, as per the global burden of disease study conducted on osteoarthritis and published in The Lancet Rheumatology Journal has stated that in 2020, globally 595 million cases of osteoarthritis were reported. The study projected that by 2050, osteoarthritis cases are expected to reach 1.1 billion. Based on the study and dataM estimates, by 2030, nearly 731 million cases are expected to be reported.

The high costs can significantly hinder the orthobiologics market growth.

Orthobiologics offer pain-free and regenerative therapy for the recipient, as compared to the surgical approaches. However, majority of the orthobiologics are expensive and are not usually covered under medical insurance. Patients, who are opting to get the orthobiologic treatment must spend out of their pockets. This can pose an economic burden on certain patient populations, especially those in the low- to middle-income category. For instance, upon review of prices from various clinics and hospitals in the U.S., the cost of a protein-rich plasma session can vary between US$1300 to US$2500 per session. A patient may need multiple sessions based on their indication, to get the therapeutic benefits.

Segment Analysis

The global orthobiologics market is segmented based on product, application, end-user, and region.

Platelet-rich plasma (PRP) in the product segment is dominating with the highest market share.

Platelet-rich plasma (PRP) is derived from the blood of the patient, by centrifuging the patient's whole blood. The concentrated plasma is rich in platelets which contain growth factors essential for tissue healing, regeneration, and inflammation modulation. In orthopedics, platelet-rich plasma (PRP) is widely used as an orthobiologic due to its ability to heal musculoskeletal tissues. t is commonly used in chronic tendinopathies like tennis elbow and patellar tendinitis, where it stimulates collagen production and repairs tendon damage. PRP also shows promise in managing osteoarthritis (OA) by reducing inflammation, alleviating pain, and slowing cartilage degradation. In fracture healing and bone grafts, PRP aids in bone regeneration by activating osteoblasts. Its anti-inflammatory properties help mitigate chronic swelling, contributing to improved joint function and mobility.

Among the other orthobiologics, PRP is the preferred choice in many conditions, as its autologous pose no immunogenic, infectious threat to patients, and is a safe and painless solution. For instance, as per the article published in the Journal of Arthroscopic Surgery and Sports Medicine in September 2024, platelet-rich plasma (PRP) has widely emerged as the most commonly used orthobiologic agent for knee osteoarthritis as it directly influences the cartilage microenvironment.

Geographical Analysis

North America is expected to hold a significant share of the Orthobiologics market.

North America region dominates the global orthobiologics market due to its advanced healthcare infrastructure, high adoption rates of innovative medical technologies such as orthobiologics, and strong research and development activities by market players. Additionally, the prevalence of orthopedic conditions, such as osteoarthritis, and sports injuries, spinal injuries are steadily rising in the region.

North America also has a significant patient population who are aware of and demand minimally invasive procedures, supported by skilled healthcare professionals who adopt emerging therapies rapidly.

According to the Centers for Disease Control and Prevention (CDC), osteoarthritis affects approximately 32.5 million adult population in the U.S. which is approximately 10% of the total population in 2023. This population is expected to rise steadily in the future due to the aging population.

Moreover, a robust pipeline of orthobiologics and collaborations between industry and academic institutions further reinforce the region's market leadership.

For instance, the American Academy of Orthopaedic Surgeons released a new 2024-2028 Strategic Plan. It focuses on collaboration efforts in the musculoskeletal (MSK) community and encourages partnerships with specialty societies, digital health organizations, etc. For orthobiologics, this collaboration can improve the development and adoption.

These are some of the factors that position North America as the leading region in the global orthobiologics market.

Competitive Landscape

The major global players in the orthobiologics market are Stryker, Zimmer Biomet., Arthrex, Inc., Sanofi, Anika Therapeutics, Inc., Ferring, Bioventus LLC, SeaSpine, Globus Medical, and Biotech among others.

Emerging Players

The emerging players in the orthobiologics market include Xtant Medical, Isto Biologics, LocateBio, Kuros Biosciences A.G., OssDsign AB, and Octane Medical Group Inc. among others.

Key Developments

• In September 2024, Xtant Medical Holdings, Inc. launched OsteoVive Plus, an extensive portfolio of viable bone grafts aimed for use in various grafting procedures. This advanced portfolio of bone grafts is featured with Xtant's proprietary Purloc Fiber Technology which produces a cohesive and moldable allograft containing a high concentration of elongated cortical fibers.
• In June 2024, Octane Medical Group announced the acquisition of B. Braun's global orthobiologics business. The acquisition is composed of two subsidiaries of B. Braun- TETEC AG in Germany and Aesculap Biologics, LLC. in the United States. The current orthobiologics portfolio includes NOVOCART 3D and NOVOCART Inject which are aimed for cartilage repair.
• In August 2024, LifeNet Health launched PliaFX Pak in the U.S. in collaboration with Johnson & Johnson MedTech. PilaFX Pak is a bone allograft made with a combination of mineralized bone chips, and moldable mineralized fibers. This advanced bone allograft finds its application in orthopedic spine and trauma procedures, including fractures, fusions, and osteotomies.
• In September 2023, Elutia Inc. announced the sale of its Orthobiologics business to Berkeley Biologics LLC, a wholly owned subsidiary of GNI Group Ltd. Elutia received US$15 million upfront payment at closing, and will receive US$20 million over the period of 5 years.
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The global orthobiologics market report would provide approximately 80 tables, 68 figures, and 185 pages.

Target Audience 2023

• Manufacturers: Pharmaceutical, Biotech Companies, Contract Manufacturers, Distributors, Hospitals.
• Regulatory & Policy: Compliance Officers, Government, Health Economists, Market Access Specialists.
• Technology & Innovation: R&D Professionals, Clinical Trial Managers, Pharmacovigilance Experts.
• Investors: Healthcare Investors, Venture Fund Investors, Pharma Marketing & Sales.
• Consulting & Advisory: Healthcare Consultants, Industry Associations, Analysts.
• Supply Chain: Distribution and Supply Chain Managers.
• Consumers & Advocacy: Patients, Advocacy Groups, Insurance Companies.
• Academic & Research: Academic Institutions.