Global Ovarian Cancer Drugs Market - 2024-2032

The global ovarian cancer drugs market reached US$ 3.58 billion in 2023 and is expected to reach US$ 6.27 billion by 2032, growing at a CAGR of 6.4% during the forecast period 2024-2031.

Ovarian cancer is the growth of abnormal cancerous cells in the ovaries, fallopian tube, or peritoneum- the major parts of the woman's reproductive system. Ovaries are made up of different cells, and depending on the neoplasms in cell type, ovarian cancers are categorized into epithelial carcinomas, germ cell tumors, and stromal cell tumors.

Ovarian cancer is one of the highly mortal cancers among women. Globally, 207k women were mortalized due to ovarian cancer in 2022, and in 2030, the mortal cases are expected to reach 250k, as projected by the World Health Organization, and International Agency for Research on Cancer.

The treatment modalities for ovarian cancer primarily include surgery, chemotherapy, and maintenance therapy with targeted drugs. The type of treatment varies on the stages of ovarian cancer.

Market Dynamics: Drivers & Restraints

Rising incidence and mortality of ovarian cancer.

Ovarian cancer is one of the leading causes of oncology-related deaths among women. The cancer is aggressive and nearly 70% of all patients experience recurrence in 18 months after the initial treatment. Globally, ovarian cancer has become a major health concern among women population. The survival rate among patients with ovarian cancer is low, with an overall five-year survival rate of 50.8%, as stated by the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program.

Moreover, the incidence rate of ovarian cancer is continuously rising. As per the International Agency for Research on Cancer statistics, new cases are projected to be 381,600 in 2030 and 447,500 in 2040, from 324,600 in 2022. The Mortality rate is similarly rising, with 250,100 deaths to occur in 2030, and 303,700 deaths in 2040, from 207,000 in 2022.

This rising incidence and mortality rates are expected to drive the demand for advanced therapeutics in the forecasted period.

The high cost of advanced therapies can hinder treatment rates and restrain market growth.

Several innovative therapies were approved by the regulatory bodies for use in ovarian cancer along with chemotherapy. These innovations include targeted therapies such as monoclonal antibodies, and enzyme poly (ADP-ribose) polymerase (PARP) inhibitors. These drugs are prescribed to reduce the recurrence and delay the progression of ovarian cancer. However, these drugs come at high prices and cause a high economic burden to the patient. This high cost may result to a decreased adoption rate among low and middle-income patient populations.

For instance, a study published in PLoS ONE journal in February 2024, stated that treatment of ovarian cancer patients with olaparib in Malaysia is expensive and may reflect an incremental cost of US$ 33,213. The life expectancy of patients treated with olaparib has increased by 3.05 years. This reflects an incremental cost-effectiveness ratio (ICER) of US$ 10,895 per life year gained.

Segment Analysis

The global ovarian cancer drugs market is segmented based on type, drug class, and region.

Drug Class:

Targeted therapy is dominating the ovarian cancer drugs market with the highest share in 2023

Targeted therapy drugs are approved for ovarian cancer as a maintenance therapy to improve the overall survival rate. These currently approved drugs include monoclonal antibodies such as bevacizumab, mirvetuximab soravtansine-gynx, and PARP inhibitors such as olaparib, niraparib, and rucaparib. The introduction of these into the market has revolutionized ovarian therapeutics. These drugs improved the survival rate, life expectancy, and quality of life, and reduced the recurrence rate.

At present PARP inhibitors have the major market share due to their high cost. These drugs are expensive and occupy a major share of the patient's out-of-pocket costs. Moreover, these drugs retain brand exclusivity and their manufacturers generate higher revenues. This is the major contributing factor for the dominance of targeted therapy in the ovarian cancer drugs market.

For instance, Zejula (niraparib) a PARP inhibitor dedicated for the treatment of advanced ovarian cancer, has reported sales of US$ 565 million in 2023. This single drug represents 15% of the 2023 ovarian cancer market share. Moreover, in 2024 a novel antibody-drug conjugate (Elahere) was launched in the U.S. and European market for the treatment of platinum-resistant ovarian cancer. The drug has reported sales of US$ 139 million in the first quarter of its launch.

There are several targeted therapies in the clinical pipeline which are anticipated to make market entry in the forecasted period. This will propel the targeted therapy market with the highest CAGR.

Geographical Analysis

North America is expected to hold a significant share of the ovarian cancer drugs market.

North America is expected to hold a significant market share due to the availability of advanced therapies. North America, being the leader in the healthcare industry, pharmaceutical companies heavily invest in developing novel therapies, and launch their product first in the region. Moreover, the demand from the patient population for these novel therapies is also higher. The patient population in the region gets first access to the medicine, and also manufacturers capture most of their revenue from the region.

For instance, in 2024, AbbVie first launched Elahere in the U.S. market and has already generated US$ 139 million in one quarter. This signifies the higher adoption rates of advanced therapies in the region.

Moreover, the rising incidence and mortality of ovarian cancer in the region is a significant contributing factor to the market growth in North America. As per the International Agency for Research on Cancer, the ovarian cancer incidence is projected to reach 30.4 thousand cases in 2040 from 24.5 thousand cases in 2022.

Competitive Landscape

The major global players in the ovarian cancer drugs market are AbbVie Inc., AstraZeneca., Merck & Co., Inc., GSK plc., pharmaand GmbH., Pfizer Inc., Amneal Pharmaceuticals LLC., Amgen, Inc., Sanofi, Teva Pharmaceuticals USA, Inc.

Key Developments

• In March 2024, The U.S. Food and Drug Administration approved ELAHERE (mirvetuximab soravtansine-gynx) and antibody-drug conjugate for the treatment of folate receptor alpha (FRa)-positive, platinum-resistant epithelial ovarian, fallopian tube or primary peritoneal adult cancer patients treated with up to three prior therapies.
• Following the U.S. FDA approval, ELAHERE received a European Commission nod for marketing authorization in November 2024, for the Treatment of platinum-resistant ovarian cancer. ELAHERE is developed by ImmunoGen, Inc., an AbbVie company.
• In July 2024, the U.S. FDA approved TEPYLUTE, a liquid form of thiotepa developed by SHORLA ONCOLOGY for the treatment of breast and ovarian cancer. This new formulation is designed to eliminate the complexities in the reconstitution of thiotepa and provide consistent dosing accuracy.
• On December 9, 2024, Merck & Co., Inc. announced results from the phase 3 KEYLYNK-001 trial that has evaluated KEYTRUDA (pembrolizumab) an immunotherapy drug combined with chemotherapy followed by maintenance therapy with LYNPARZA (Olaparib), with or without bevacizumab, as a first-line treatment for people with BRCA non-mutated advanced epithelial ovarian cancer. The therapy has met the primary end-point but has failed to meet the secondary end-points.

Emerging Players

The emerging players in the anti-amyloid monoclonal antibodies market include Corcept Therapeutics, Incorporated, SHORLA ONCOLOGY, DAIICHI SANKYO COMPANY, LIMITED., Zentalis Pharmaceuticals., Shenzhen Chipscreen Biosciences Co., Ltd., etc.

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The global ovarian cancer drugs market report would provide approximately 54 tables, 43 figures, and 184 pages.

Target Audience 2023

• Manufacturers: Pharmaceutical, Biotech Companies, Contract Manufacturers, Distributors, Hospitals.
• Regulatory & Policy: Compliance Officers, Government, Health Economists, Market Access Specialists.
• Technology & Innovation: R&D Professionals, Clinical Trial Managers, Pharmacovigilance Experts.
• Investors: Healthcare Investors, Venture Fund Investors, Pharma Marketing & Sales.
• Consulting & Advisory: Healthcare Consultants, Industry Associations, Analysts.
• Supply Chain: Distribution and Supply Chain Managers.
• Consumers & Advocacy: Patients, Advocacy Groups, Insurance Companies.
• Academic & Research: Academic Institutions.