Gonadotropin-Releasing Hormone (GnRH) Agonists and Antagonists Drugs Market - 2024-2031

Report Overview

The Global Gonadotropin-Releasing Hormone (GnRH) Agonists and Antagonists Drugs Market reached US$ 1.64 billion in 2023 and is expected to reach US$ 3.39 billion by 2031, growing at a CAGR of 9.6% during the forecast period 2024-2031.

The gonadotropins are peptide hormones that regulate ovarian and testicular function and are essential for normal growth, sexual development, and reproduction. The human gonadotropins include follicle-stimulating hormone (FSH) and luteinizing hormone (LH) which are made in the pituitary, and chorionic gonadotropin (hCG) which is made by the placenta. Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle-stimulating hormone and luteinizing hormone, which then regulate both the endocrine function and gamete maturation in the gonads.

Gonadotropin-releasing hormone (GnRH) agonists are synthetic substances that prevent the ovaries and testicles from producing sex hormones. They work by blocking other hormones that are required for sex hormone production. Gonadotropin-releasing hormone (GnRH) antagonists are a class of drugs that block the pituitary gland from producing hormones like follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Market Dynamics: Drivers

Increasing prevalence of ovarian and prostate cancers

The rising prevalence of ovarian and prostate cancers propels the market growth. For instance, In the UK, more than 52,000 men are diagnosed with prostate cancer every year on average, that is 144 men every day. More than 44,000 men are diagnosed with prostate cancer every year in England. More than 10,000 men die from prostate cancer every year in England. More than 3,800 men are diagnosed with prostate cancer every year in Scotland. More than 1,000 men die from prostate cancer every year in Scotland. More than 2,800 are diagnosed with prostate cancer every year in Wales. Around 630 men die from prostate cancer every year in Wales.

Moreover, according to the World Cancer Research Fund International, ovarian cancer is the 18th most common cancer worldwide. It is the 8th most common cancer in women. There were more than 324,603 new cases of ovarian cancer in 2022. Around

206,956 women died of ovarian cancer. The rate of new cases of ovarian cancer was 10.2 per 100,000 women per year. The death rate was 6.0 per 100,000 women per year. Approximately 1.1 percent of women will be diagnosed with ovarian cancer at some point during their lifetime.

Restraints

Factors such as adverse effects and risks related to gonadotropin-releasing hormone agonists and antagonists are expected to hamper the market. In some cases, the usage of GnRH agonists and antagonists results in hot flashes, gynecomastia, fatigue, weight gain, fluid retention, erectile dysfunction, decreased libido, decrease in bone density, and irregular menstrual cycle.

Market Segment Analysis

The global GnRH agonists and antagonists drugs market is segmented based on drug type, application, end-user, and region.

The segment GnRH agonists accounted for approximately 43.6% of the global GnRH agonists and antagonists drugs market share

The GnRH agonists segment is expected to hold the largest market share over the forecast period. In this segment, technological advancements would drive this market.

Gonadotropin-releasing hormone (GnRH) agonists work by temporarily switching off the ovaries by signaling the brain not to develop an egg. This causes the ovaries to stop producing estrogen and progesterone, which can help with a number of health conditions. GnRH agonists can help treat estrogen receptor-positive breast cancer cells by stopping the ovaries from producing estrogen. GnRH agonists can help thin the endometrium before endometrial ablation procedures

For instance, in June 2023, the US Food and Drug Administration approved the use of leuprolide acetate in a depot preparation, goserelin implant, and intranasal nafarelin for up to six months when administered alone for the treatment of symptomatic endometriosis.

Market Geographical Analysis

North America accounted for approximately 49.3% of the global GnRH agonists and antagonists drugs market share

North America region is expected to hold the largest market share over the forecast period. The rising incidence of prostate and ovarian cancers and endometriosis, and technological advancements among people, in this region, help to propel the market.

For instance, according to the U.S. Department of Health and Human Services, endometriosis happens when tissue similar to the lining of the uterus (womb) grows outside of the uterus. It may affect more than 11% of American women between 15 and 44. It is widespread among women in their 30s and 40s and may make it harder to get pregnant. Several different treatment options can help manage the symptoms and improve your chances of getting pregnant. Endometriosis affects an estimated 2 to 10 percent of American women between the ages of 25 and 40.

Moreover, according to an article published Centers for Disease Control and Prevention, based on the most recent data available, in the United States in 2022, 33,363 males died from prostate cancer. The rate of new cases of prostate cancer was 116.5 per 100,000 men per year. The death rate was 19.0 per 100,000 men per year. Approximately 12.8 percent of men will be diagnosed with prostate cancer at some point during their lifetime.

Market Segmentation

By Drug Type

GnRH Agonists

Leuprorelin

Goserelin

Triptorelin

Histrelin

Buserelin

GnRH Antagonists

Degarelix

Abarelix

Cetrorelix

Ganirelix

By Application

Gynecology

Oncology

Others

By End-User

Hospitals

Specialty Clinics

Others

By Region

North America

U.S.

Canada

Mexico

Europe

Germany

U.K.

France

Spain

Italy

Rest of Europe

South America

Brazil

Argentina

Rest of South America

Asia-Pacific

China

India

Japan

South Korea

Rest of Asia-Pacific

Middle East and Africa

Market Competitive Landscape

The major global players in the global GnRH agonists and antagonists drugs market include Bayer AG, Ferring, Abbvie Inc., AstraZeneca, Merck KGaA, Ipsen Pharma, TerSera Therapeutics LLC, Takeda Pharmaceutical Company Limited, Cipla, Lupin among others.

Key Developments

In November 2023, Global pharma major Lupin Limited (Lupin) announced that it had received approval from the United States Food and Drug Administration (U.S.FDA) for its Abbreviated New Drug Application for Ganirelix Acetate Injection, 250 mcg/0.5 mL Single-Dose Prefilled Syringe, to market a generic equivalent to the reference listed drug (RLD), of Ganirelix Acetate Injection, 250 mcg/0.5 mL of Organon USA LLC. Ganirelix is Lupin's first peptide-based injectable, strengthening the Company's commitment to innovative healthcare solutions.

Why Purchase the Report?

To visualize the global GnRH agonists and antagonists drugs market segmentation based on drug type, application, end-user, and region, as well as understand key commercial assets and players.

Identify commercial opportunities by analyzing trends and co-development

Excel data sheet with numerous data points of global GnRH agonists and antagonists drugs market level with all segments.

PDF report consists of a comprehensive analysis after exhaustive qualitative interviews and an in-depth study.

Product mapping is available in Excel consisting of key products of all the major players.

The global GnRH agonists and antagonists drugs market report would provide approximately 51 tables, 54 figures, and 181 Pages.

Target Audience 2024

Manufacturers/ Buyers

Industry Investors/Investment Bankers

Research Professionals

Emerging Companies