PUBLISHER: DelveInsight | PRODUCT CODE: 1663183
PUBLISHER: DelveInsight | PRODUCT CODE: 1663183
DelveInsight's "Postoperative Pain Drugs Market Insights, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding of postoperative pain, historical and forecasted epidemiology, as well as the postoperative pain market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
The Postoperative Pain Drugs Market report provides current treatment practices, emerging drugs, Postoperative Pain market share of individual therapies, and current and forecasted 7MM postoperative pain market size from 2020 to 2034. The Postoperative Pain drugs market report also covers postoperative pain treatment market practices/algorithms and Postoperative Pain unmet needs to curate the best opportunities and assess the market's potential.
Postoperative Pain Treatment Market: Overview
Postoperative pain is the expected, transient rise in baseline pain that occurs after surgery. It is a kind of pain that usually subsides in a matter of days to months, or it may be pain that is directly associated with soft tissue injury, like an ankle sprain or paper cut. Although the pain is brief, it eventually goes away as the damaged tissues heal. Each patient's experience of pain is unique and multifaceted. Preoperative psychological and pharmaceutical preparation, type of anesthesia, pain management before and after the surgical procedure, the incidence of surgical complications, and quality of postoperative care are the main factors influencing the intensity, quality, and duration of postoperative pain. Other factors include the location, type, and duration of the surgical procedure, the type and extent of the incision and surgical trauma, and the patient's physical and mental state, including their approach to pain.
Postoperative Pain Diagnosis
Appropriate and focused treatment of acute pain depends on a precise diagnosis of the kind and severity of the pain. The location and radiation of the pain, its intensity (dull, sharp, throbbing, shooting, burning, etc.), its duration (constant, intermittent, paroxysmal), its causative factors (movement, sitting position, cough, etc.), its accompanying symptoms, its quality of sleep, its assessment of the patient's expectations, its approach to pain, stress, and pain coping strategies, and its preferences for analgesic therapy are all considered in a specific evaluation of pain.
Postoperative pain Treatment
The treatment strategy for postoperative pain typically employs a multimodal approach aimed at optimizing pain relief while minimizing adverse effects and complications. Despite most surgical patients experiencing acute postoperative pain, studies indicate that less than half report satisfactory pain relief afterward. This treatment pattern encompasses both pharmacological and non-pharmacological interventions. Pharmacological therapies include various types of analgesics such as opioids, NSAIDs, acetaminophen, corticosteroids, and anesthetics. Additionally, benzodiazepines, muscle relaxants, antidepressants, alpha-2 agonists, gamma-aminobutyric agonists, and cannabinoids are utilized for acute pain management. Non-pharmacological approaches encompass acupuncture, psychological methods like cognitive behavioral therapy and mindfulness-based stress reduction, chiropractic manipulation, physical therapy, transcutaneous electrical stimulation, massage therapy, exercise, and other complementary and alternative medicine therapies. This comprehensive approach is known as multimodal analgesia.
Opioids are a large group of pain-relieving drugs that are used for reducing pain in postoperative cases. These drugs majorly include fentanyl, hydromorphone, morphine, oxycodone, oxymorphone, and tramadol. Examples of opioids prescribed in pill form after surgery include oxycodone. The approved opioids include Zalviso, Olinvyk (Olinvo), Dzuveo (Dsuvia), Nucynta, DepoDur, etc.
The real-world prescription analysis reveals that patients with postoperative pain commonly receive treatment with opioids, NSAIDs, corticosteroids, and anesthetics. However, there has been a concerning trend over the past decade, particularly in the US, where there has been an increasing reliance on opioids for pain management, contributing to an opioid misuse epidemic. One significant contributor to opioid misuse is their frequent prescription for severe pain after surgery or acute injuries. In contrast, evidence indicates that opioids are used less frequently in Japan compared to the US. In the US, the primary modifiable risk factors for persistent postoperative opioid use include the use of modified-release opioids, prolonged initial prescription durations, and repeated prescriptions. Opioid use and misuse are also significant issues in the UK, with recent research linking prolonged opioid use to surgical procedures.
Leading medical organizations such as the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists Committee on Regional Anesthesia strongly advocate for clinicians to consider incorporating paracetamol (acetaminophen) or NSAIDs into multimodal analgesic regimens for both adult and pediatric patients, unless there are specific contraindications. This recommendation is supported by robust evidence.
As the Postoperative Pain drugs market is derived using a patient-based model, the postoperative pain epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by the total number of surgical procedures, total number of incident cases of postoperative pain, severity-specific incident cases of postoperative pain the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan from 2020 to 2034.
Postoperative Pain Drugs Market Chapters
The drug chapter segment of the postoperative pain therapeutics market report encloses a detailed analysis of postoperative pain-marketed drugs and mid to late-stage (Phase III and Phase II) Postoperative Pain pipeline drugs analysis. It also helps to understand the postoperative pain clinical trials details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest Postoperative Pain news and press releases.
Postoperative Pain Marketed Drugs
DEXTENZA is dexamethasone delivered via hydrogel technology. It is a corticosteroid indicated for treating ocular inflammation and pain following ophthalmic surgery and for treating ocular itching associated with allergic conjunctivitis.
The Ocular Therapeutix product, DEXTENZA, is only approved in the US, where it received approval in December 2018 for treating ocular pain following ophthalmic surgery. However, later in June 2019, the US FDA approved the supplemental new drug application for DEXTENZA to include the treatment of ocular inflammation following ophthalmic surgery as an additional indication.
Ocular Therapeutics DEXTENZA contains practically all the key attributes one would want to see in a new medical product in the post-ophthalmology surgery sector, particularly cataract surgery. It allows patients to receive a whole course of steroid treatment with just one preservative-free insert, which is given by the ocular surgeon during surgery or an ophthalmologist following surgery. The current standard of treatment might call for as many as 70 steroidal eye drops to be administered over a month, with varying dose frequencies. For physicians, DEXTENZA puts control of post-surgical steroid treatment back in their hands by mitigating the risk of patient noncompliance. DEXYCU is the direct competitor of DEXTENZA because most patients will get either DEXTENZA or DEXYCU, and 100% of them are manageable for elevated IOP, even the high responders.
Postoperative Pain Emerging Drugs
IV Tramadol, is a centrally-acting synthetic analgesic of the aminocyclohexanol group with opioid-like effects. Tramadol is extensively metabolized following administration, which results in several enantiomeric metabolites that display different opioid-receptor binding properties and monoaminergic reuptake inhibition. Tramadol is a synthetic dual-acting opioid with a well-established efficacy and safety profile and has been used throughout the world for more than 30 years, accumulating an abundance of available clinical data. Oral tramadol is currently approved and marketed in the US.
Currently, the drug candidate is being investigated for post-operative surgical pain, further, they are planning to initiate a final Phase III safety study with anticipated rights in the US.
Oculis is developing OCS-01 (dexamethasone cyclodextrin nanoparticle ophthalmic suspension 1.5% mg/mL), a novel formulation of dexamethasone using Oculis proprietary Solubilizing Nanoparticle (SNP) technology. OCS-01 has completed a Phase II trial in inflammation and pain following cataract surgery (SKYGGN trial), with 153 patients providing the first POC of a once-daily topical steroid. A long-acting topical. OCS-01 has also completed another Phase II trial in DME. Following the completion of both Phase II trials, an end-of-phase II meeting was conducted with the FDA, and as per the company, the product candidate is now moving into Phase III in both indications.
Currently, the drug candidate is being investigated in a Phase III clinical trial for post-operative pain and inflammation eye, expected to be completed by July 2024.
Opiranserin (VVZ-149) for injection, developed by Vivozon, represents a groundbreaking non-narcotic analgesic being developed to address postoperative pain. It is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A). Positioned as a primary treatment option in the global market, VVZ-149 aims to supplant opioid analgesics by offering an efficient and safe alternative for pain management. To tackle opioid misuse and abuse, VVZ-149 is being assessed in Phase III clinical trials in both Korea and the US.
Postoperative Pain Drugs Market Insights
The current postoperative pain treatment market consists of different approaches classified into pharmacologic and non-pharmacological therapies. The pharmacological therapies include analgesics that are further segregated into opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, corticosteroids, anesthetics, etc. Acute pain is also managed by the use of benzodiazepines, muscle relaxants, antidepressants, alpha-2 agonists, gamma-aminobutyric agonists, and cannabinoids. Further, non-pharmacological therapies include acupuncture, psychological approaches (cognitive behavioral therapy, mindfulness-based stress reduction), chiropractic manipulation, physical therapy, transcutaneous electrical stimulation, massage therapy, exercise, and other complementary and alternative medicine therapies (CAM). All these involve the concept known as multimodal analgesia.
In recent years, extensive changes have been observed in the postoperative pain management market. Opioids such as fentanyl, hydromorphone, and morphine were a gold standard, but these are being replaced by other more beneficiary approaches, such as multimodal analgesia, which has been the talk of the town. NSAIDs have become a sensible choice due to their effectiveness in pain reduction after surgical procedures. Moreover, NSAIDs have been recognized to decrease opioid consumption by less than 50%, provide superior analgesia when combined with opioids, have been proposed as first-line medications for mild-to-moderate pain, and possess several side effects. The drugs included in this category are exparel, acetaminophen, tramadol, gabanoids, gabapentin, pregabalin, and Ibuprofen.
Efficient pain management is critical for patients undergoing surgery, with its physiological benefits increasingly recognized as a key postoperative quality measure. Postoperative pain management seeks to alleviate discomfort with minimal side effects, yet evidence indicates that less than half of surgical patients achieve satisfactory pain relief.
Despite the growing awareness of the value of multimodal pain management plans, opioid monotherapy remains the foundation of post-surgical pain therapy. Opioids delivered by patient-controlled analgesia support systemic analgesia for treating moderate-to-severe postoperative pain. Analgesics that act by different mechanisms and at various receptor sites are normally combined to produce additive or synergistic pain relief and can reduce opioid use. Regimens that use nonopioid analgesics include paracetamol, NSAIDs (cyclooxygenase inhibitors), alpha 2 agonists (clonidine, dexmedetomidine), gabapentin, pregabalin, ketamine, lignocaine infusions, and peripheral nerve blocks, local anesthetic wound infiltration, and continuous wound infusion techniques.
The Postoperative Pain Therapeutics Market has been categorized by drug class (Opioids, NSAIDs, Cyclooxygenase-2-selective Inhibitors (COX-2) and local anesthetics, etc.), Route of administration (injectable, oral, topical, and other routes), and distribution channels (hospital and retail pharmacies and other available channels). The expected launch of upcoming therapies and greater integration of early patient screening, medication in secondary care and other clinical settings, research on best methods for implementation, and an upsurge in awareness will eventually facilitate the development of effective treatment options.
The current Postoperative Pain Therapeutics Market segmentation is based on the off-label therapies prescribed. The drugs that are being used in the present market include bronchodilators, diuretics, antibiotics, steroids, and others. These are the major segments covered in the forecast model.
This section focuses on the uptake rate of potential Postoperative Pain drugs expected to be launched in the market during 2020-2034. For example, IV Tramadol by Avenue Therapeutics is expected to enter the US market in 2028 with a "slow" uptake.
Postoperative Pain Pipeline Development Activities
The Postoperative Pain pipeline segment provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I. It also analyzes key Postoperative Pain companies involved in developing targeted therapeutics.
Pipeline Development Activities
The Postoperative Pain pipeline segment covers information on collaborations, acquisitions and mergers, licensing, and patent details for emerging therapies for postoperative pain.
KOL Views
To keep up with current Postoperative Pain treatment market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on the postoperative pain evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake, along with challenges related to accessibility, including Medical/scientific writers, Medical Professionals, Professors, Directors, and Others.
DelveInsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Centers like the University of Utah, University of California, San Francisco, University of Michigan Medical School, US, University of Versailles-St-Quentin, University Hospital Jena, Germany, Royal College of Anesthetists, UK, Shinshu University School of Medicine, Japan were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or postoperative pain market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
Physician's View
According to our primary research analysis, despite advancements in the postoperative pain treatment, significant unmet needs persist in effectively managing this complex disorder. Physicians are increasingly promoting the use of multimodal analgesia in postoperative pain management to reduce dependency on opioids and lower the likelihood of opioid-related issues. However, a significant obstacle is the absence of personalized treatment approaches. Each patient's pain response is distinct and influenced by various factors like genetics, age, existing health conditions, and the type of surgery. Customizing treatment plans according to individual patient needs can enhance pain relief while reducing the potential for adverse effects and enhancing overall recovery outcomes.
According to a KOL in the US, eye drops treatment that comes in the combination of corticosteroids, NSAIDs, and antibiotics is usually preferred by clinicians after ocular surgery. Eye drops are effective only in patients who are compliant but for noncompliant patients like elderly patients, it usually becomes problematic. After the approval of Dextenza, poorly compliant patients, which are around 50%, are likely to get prescribed Dextenza.
As per another KOL, among the patients undergoing surgery in Europe, 30% experience severe postoperative pain during the first 24 h. Also, 13% of these surgical patients experience moderate to severe postoperative pain on day 3 and 9% on day 14 after the surgical procedure.
Qualitative Analysis
We perform Qualitative and Postoperative Pain treatment market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy. In efficacy, the trial's primary and secondary outcome measures are evaluated; for instance incidence of overall adverse events (AEs), serious adverse events (SAEs), and AEs leading to discontinuation, and others.
Further, the therapies' safety is evaluated wherein the adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials, which directly affects the safety of the molecule in the upcoming trials. It sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Postoperative Pain Treatment Market Access and Reimbursement
The high cost of therapies for the treatment is a major factor restraining the growth of the drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment. The reimbursement challenges related to medical care and treatment for individuals with postoperative pain can be significant as it often requires specialized medical attention, covering the costs of diagnosis, treatment, and ongoing care. Health insurance plans may not fully cover limited coverage of some medical treatments, and therapies specific to postoperative pain. This can result in high out-of-pocket expenses for families seeking the best care for their loved ones. Moreover, it requires specialized care from healthcare providers with expertise. Finding and accessing such specialists may be challenging, and the associated costs may not always be fully reimbursed by insurance.
The Postoperative Pain report provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenarios, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Postoperative Pain Therapeutics Market Report Scope
Postoperative Pain Therapeutics Market Report key strengths
Postoperative Pain Therapeutics Market Insights
Postoperative Pain Epidemiology Insights
Current Postoperative Pain Treatment Market Scenario, Marketed Drugs, and Emerging Therapies