Angioedema- Pipeline Insight, 2025

DelveInsight's, "Angioedema- Pipeline Insight, 2025" report provides comprehensive insights about 20+ companies and 20+ pipeline drugs in Angioedema pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered:

• Global coverage

Angioedema: Understanding

Angioedema: Overview

Angioedema is defined as "subcutaneous tissues and/or submucosal tissues circumscribed non-pitting edema affecting lips, face, neck, and extremities oral cavity, larynx, and gut." It becomes life-threatening when it involves the larynx, while intestinal angioedema is painful and mimics acute abdomen. In inherited (hereditary angioedema) mutations in the gene encoding for C1-inhibitor cause hereditary angioedema and it is an autosomal dominant condition. Hereditary angioedema is a rare disease that often leads to delay in diagnosis as well as a misdiagnosis. Other factors leading to a misdiagnosis are unknown family history, gastrointestinal manifestations of disease without cutaneous involvement. Angioedema is caused by an increase in local capillary permeability and plasma extravasation, usually mediated by mast cells, histamine, or bradykinin release. Angioedema is most commonly histamine-mediated; mast cell and basophil stimulation results in histamine release. Angioedema with urticaria tends to suggest a histaminergic form, which includes acute allergic angioedema and histaminergic idiopathic angioedema. The exact cause depends on the type of angioedema a patient has.

Symptoms of angioedema typically appear suddenly and may remain for up to 3 days. Swelling beneath the skin's surface is the most common symptom of angioedema and may affect a person's hands, genitals, feet, legs, eyes, throat, tongue, bowel lining. Other symptoms may include a hot, prickling, or painful sensation, an itchy, red rash (urticaria), impaired vision, abdominal pain, bladder problems and difficulty breathing.

The diagnosis of angioedema is based on appearance of symptoms and a description of what may have triggered symptoms requesting and reviewing a person's family, medication, and medical history. If a person was exposed to a common allergen before angioedema occurred, allergic angioedema is likely. Alternatively, a family history of angioedema may suggest that angioedema presenting is hereditary. Tests used to diagnose the angioedema includes a skin prick test in which the skin is pricked with a very small amount of the suspected allergen, a blood test to see how the immune system reacts to a certain allergen, and a blood test to check for C1 esterase inhibitors, where low levels or dysfunction suggests the problem is hereditary. Treatment for angioedema depends on the type and cause, although most cases improve after a few days without treatment. Identifying and avoiding an allergen that may have caused angioedema is key to preventing further symptoms. If intervention is required, medications prescribed may include antihistamines, corticosteroids, epinephrine (EpiPen). If the cause is hereditary, there is no cure. However, a person may receive several types of treatment to help prevent angioedema symptoms, such as receiving specialized medications, a concentrate of the C1 inhibitor the protein they are missing and fresh frozen plasma. If a person experiences sudden swelling or trouble breathing, urgent medical attention is required. The most important action is to ensure a free airway, so a breathing tube might be placed for safety.

"Angioedema- Pipeline Insight, 2025" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Angioedema pipeline landscape is provided which includes the disease overview and Angioedema treatment guidelines. The assessment part of the report embraces, in depth Angioedema commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Angioedema collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights:

• The companies and academics are working to assess challenges and seek opportunities that could influence Angioedema R&D. The therapies under development are focused on novel approaches to treat/improve Angioedema.

Angioedema Emerging Drugs Chapters

This segment of the Angioedema report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Angioedema Emerging Drugs

• Donidalorsen: Ionis Pharmaceuticals

Donidalorsen, formerly known as IONIS-PKK-LRx, is a ligand-conjugated (LICA) investigational antisense medicine designed to reduce the production of prekallikrein, or PKK, to treat patients with hereditary angioedema, or HAE. PKK plays an important role in the activation of inflammatory mediators associated with acute attacks of HAE. HAE is a rare genetic disease characterized by rapid and painful attacks of inflammation in the hands, feet, limbs, face, abdomen, larynx and trachea. HAE can be fatal if swelling occurs in the larynx. In patients with frequent or severe attacks, doctors may use prophylactic treatment approaches to prevent and reduce the severity of HAE attacks. However, current prophylactic treatment approaches are very limited and have major tolerability issues due to challenging administration requirements leaving patients with few therapeutic options. Currently, the drug is in Phase III stage of its development for the treatment of hereditary angioedema.

• NTLA-2002: Intellia Therapeutics

NTLA-2002 is Intellia's wholly owned development candidate for the treatment of HAE and is company's second in vivo knockout therapeutic candidate. NTLA-2002 is currently being studied in a first-in-human Phase 1/2 clinical trial Based on Nobel Prize-winning CRISPR/Cas9 technology, NTLA-2002 is the first single-dose investigational treatment being explored in clinical trials for the potential to continuously reduce kallikrein activity and prevent attacks in people living with hereditary angioedema (HAE). NTLA-2002 is a wholly owned investigational CRISPR therapeutic candidate designed to inactivate the kallikrein B1 (KLKB1) gene, which encodes for prekallikrein, the kallikrein precursor protein. NTLA-2002 is Intellia's second investigational CRISPR therapeutic candidate to be administered systemically, by intravenous infusion, to edit disease-causing genes inside the human body with a single dose of treatment. Currently, the drug is in Phase III stage of its development for the treatment of hereditary angioedema.

• STAR-0215: Astria Therapeutics, Inc

STAR-0215, is a potential best-in-class monoclonal antibody inhibitor of plasma kallikrein designed to provide long-acting, safe, and effective attack prevention for HAE, with potential for dosing once every 3 and 6 months. Positive results from the Phase 1a clinical trial in healthy subjects support early proof of concept for STAR-0215's potential target profile: a long-acting preventative therapy, best-in-class PK profile, and dosing once every 3 and 6 months. Currently, the drug is in Phase II stage of its development for the treatment of hereditary angioedema.

Angioedema: Therapeutic Assessment

This segment of the report provides insights about the different Angioedema drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players in Angioedema
• There are approx. 20+ key companies which are developing the therapies for Angioedema. The companies which have their Angioedema drug candidates in the most advanced stage, i.e. phase III include, Ionis Pharmaceuticals.
• Phases

DelveInsight's report covers around 20+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Angioedema pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Angioedema: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Angioedema therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Angioedema drugs.

Angioedema Report Insights

• Angioedema Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Angioedema Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions:

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Angioedema drugs?
• How many Angioedema drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Angioedema?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Angioedema therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Angioedema and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Ionis Pharmaceuticals, Inc.
• Astria Therapeutics, Inc.
• Intellia Therapeutics
• BioMarin Pharmaceutical
• Incyte Corporation
• Novartis
• KalVista Pharmaceuticals, Ltd.
• Sanofi
• Pharvaris Netherlands B.V.
• ADARx Pharmaceuticals, Inc.
• CSL Behring
• CAMP4 Therapeutics

Key Products

• Donidalorsen
• STAR-0215
• NTLA-2002
• BMN 331
• Povorcitinib
• LOU064
• KVD900
• Dupilumab
• Deucrictibant
• ADX-324
• Garadacimab
• Research programme: liver disorder therapeutic