PUBLISHER: DelveInsight | PRODUCT CODE: 1605438
PUBLISHER: DelveInsight | PRODUCT CODE: 1605438
DelveInsight's "Parkinson's disease - Market Insights, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding of the Parkinson's disease, historical and forecasted epidemiology as well as the Parkinson's disease market trends in the United States, EU4 and the UK (Germany, France, Italy, Spain) and the United Kingdom, and Japan.
The Parkinson's disease market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Parkinson's disease market size from 2020 to 2034. The Report also covers current Parkinson's disease treatment practice, market drivers, market barriers, SWOT analysis, reimbursement and market access, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.
Study Period: 2020-2034
Parkinson's disease Overview
According to the Parkinson's Foundation, Parkinson's disease is a neurodegenerative disorder that affects predominately dopamine-producing (dopaminergic) neurons in a specific area of the brain called the substantia nigra. Because Parkinson's disease develops over time, various stages help identify how symptoms have progressed and what should be expected next. Generally, there are five stages of Parkinson's disease: Stage I, Stage II, Stage III, Stage IV, and Stage V.
Parkinson's disease diagnosis
Diagnosing Parkinson's disease can be challenging, as there is no definitive test for the condition. Instead, the diagnosis is typically based on a combination of medical history, symptoms, physical and neurological examinations, and sometimes additional tests. MRI may be used only to exclude other causes. DaTscan, an imaging test, can assist in confirming the diagnosis by assessing dopamine levels in the brain. Additionally, advancements in neuroimaging studies, including transcranial Doppler ultrasonography, PET, single-photon emission computed tomography (SPECT), morphometric MRI studies, tractography, functional MRI, and perfusion imaging, are being used to differentiate idiopathic Parkinson's disease from other parkinsonian disorders. Radionuclide imaging modalities like PET and SPECT, using a dopamine transporter ligand, have become the best approach to assess dopamine metabolism and deficiency.
Parkinson's disease treatment
Treatment involves pharmacologic approaches, typically with levodopa preparations prescribed with or without other medications, MAO-B inhibitors, COMT inhibitors, amantadine, and anticholinergics, and non-pharmacologic approaches (such as exercise, physical, occupational, and speech therapies). Approaches such as deep brain stimulation and treatment with levodopa-carbidopa enteral suspension can help individuals with medication-resistant tremors, worsening symptoms when the medication wears off, and dyskinesia.
The management of Parkinson's disease aims at improving the quality of life for individuals affected by the condition with symptomatic relief. There are several medications approved by the US FDA such as, XADAGO, DUOPA/DUODOPA, INBRIJA, ONGENTYS, and others are also being used to treat motor and non-motor symptoms associated with Parkinson's disease.
As the market is derived using a patient-based model, the Parkinson's disease epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by, Total Diagnosed Prevalent Cases of Parkinson's Disease, Gender-specific Diagnosed Prevalent Cases of Parkinson's Disease, Age-specific Diagnosed Prevalent Cases of Parkinson's Disease, Stage-specific Diagnosed Prevalent Cases of Parkinson's Disease, Diagnosed Prevalent Cases of Psychosis due to Parkinson's Disease, and Diagnosed Prevalent Cases of MCI due to Parkinson's Disease in the 7MM covering, the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2020 to 2034.
The drug chapter segment of the Parkinson's disease report encloses a detailed analysis of Parkinson's disease off-label drugs and late-stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Parkinson's disease clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
Marketed Drugs
CREXONT (carbidopa and levodopa) ER capsules: Amneal Pharmaceuticals
CREXONT is a novel oral formulation of carbidopa/levodopa (CD/LD) that combines immediate-release (IR) granules and extended-release (ER) pellets. This prescription medication is used to treat Parkinson's disease, Parkinson's disease caused by brain infection or inflammation, and Parkinson's disease-like symptoms resulting from carbon monoxide or manganese poisoning in adults. The ER beads in CREXONT consist of levodopa (LD), coated with a sustained-release polymer for slow drug release, a mucoadhesive polymer to ensure the granules remain at the absorption site longer, and an enteric coating to prevent premature disintegration in the stomach. This formulation is distinct from RYTARY (carbidopa/levodopa) extended-release capsules, Amneal's extended-release CD/LD treatment for Parkinson's disease approved by the US FDA in 2015.
In February 2024, Amneal Pharmaceuticals entered into an exclusive licensing agreement with Zambon Biotech for IPX203 (CREXONT) in the European Union.
In August 2024, the US FDA approved CREXONT extended-release capsules for the treatment of Parkinson's disease.
Emerging Drugs
SPN-830 (apomorphine infusion device): Supernus Pharmaceutical/Britannia Pharmaceuticals
SPN-830 (apomorphine infusion device) is an investigational apomorphine infusion device under review for the continuous treatment of motor fluctuations (OFF episodes) in Parkinson's disease patients that are not adequately controlled with oral levodopa and one or more adjunct Parkinson's disease medications. SPN-830 is an SC formulation of apomorphine delivered continuously through a portable electronic infusion pump under the skin for 14-18 h. The target infusion rate ranged between 3 mg and 8 mg per h. The thin, small needle applied underneath the skin is usually placed on the abdomen or upper thigh. Such administration has the potential to be less invasive, with fewer injection sites, and is more convenient than Supernus Pharmaceutical's already approved product APOKYN, which mimics the action of dopamine in the brain, is intended to reduce off periods on demand, and is administered under the skin.
In April 2024, the US FDA issued a complete response letter (CRL) for Supernus Pharmaceuticals' NDA for SPN-830.
Additionally, in August 2024, Supernus Pharmaceuticals resubmitted its NDA for the apomorphine infusion device (SPN-830) to provide continuous treatment for motor fluctuations (OFF episodes) in Parkinson's disease.
Parkinson's disease is a progressively worsening neurodegenerative disorder with an unclear cause and pathogenesis. Its global burden is increasing, driven by aging populations and environmental factors. Classic symptoms include motor issues like bradykinesia, rigidity, tremors, and postural instability, along with non-motor symptoms such as depression, cognitive impairment, and autonomic disturbances, which significantly affect quality of life. Diagnosing Parkinson's is challenging due to symptom overlap with other movement disorders, with imaging like PET scans aiding in diagnosis.
While no curative therapy exists, various pharmacological and non-pharmacological treatments are used to manage symptoms. Carbidopa/levodopa remains the most effective treatment, with new formulations like CREXONT (approved in August 2024) and RYTARY (approved in 2015) offering symptom relief. DUOPA, a carbidopa/levodopa enteral suspension, and HARUROPI TAPE (ropinirole HCL), a transdermal patch, provide additional options, though innovations have been limited.
The Parkinson's disease treatment landscape faces significant unmet needs, particularly for curative and disease-modifying therapies. Better motor symptom control, especially for tremors, gait, balance, and psychosis treatment, remains a critical challenge.
Nevertheless, a plethora of medications is under development. These include drugs that specifically target a-synuclein pathology, widely considered to be the driver of neurodegeneration in Parkinson's disease. These drugs offer hope for disease-modifying agents in the short- to medium-term future. In combination with several regenerative approaches, including stem cells and gene therapies, therapeutics for Parkinson's disease are likely to see significant advances over the coming years, with several novel, effective options likely to become available in the foreseeable future.
The current emerging pipeline is robust, late-stage drugs expected to enter the Parkinson's disease market during the forecast period include Supernus Pharmaceuticals/Britannia Pharmaceuticals' SPN-830 (apomorphine infusion pump), AbbVie's tavapadon, Pharma Two B's P2B001 (extended-release pramipexole and rasagiline), and Mitsubishi Tanabe Pharma Corporation (NeuroDerm)'s ND0612 (levodopa/carbidopa), among others. The approval of these therapies could significantly impact market dynamics, although their success rates remain uncertain.
This section focuses on the uptake rate of potential drugs expected to launch in the market during 2020-2034. For example, SPN-830 in the US is expected to be launched by 2025 with a peak share of 2.50%. Tavapadon is anticipated to take 7 years to peak with a medium uptake.
Parkinson's Disease Pipeline Development Activities
The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I stage. It also analyzes key players involved in developing targeted therapeutics.
Pipeline Development Activities
The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Parkinson's disease emerging therapies.
KOL Views
To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Parkinson's disease evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Parkinson's Foundation, Miami, US; Stanford University, US; Pacific Health Research and Education Institute, Honolulu, HI US; Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Germany; Sante publique France, French Public Health Agency, Saint-Maurice, France; Sante publique France, French Public Health Agency, Saint-Maurice, France; Universitario Central de Asturias, Spain; and Department of Neurology, The Jikei University Katsushika Medical Center, Tokyo, Japan.
Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps understand and validate current and emerging therapies, treatment patterns, or Parkinson's disease market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
Qualitative Analysis
We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Access and Reimbursement
The high cost of therapies for the treatment is a major factor restraining the growth of the global drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Market Insights
Epidemiology Insights
Current Treatment Scenario, Marketed Drugs, and Emerging Therapies
The Parkinson's Disease Epidemiology and Market Insight report for the 7MM covers the forecast period from 2024 to 2034, providing a projection of market dynamics and trends during this timeframe.
The Parkinson's Disease market is quite robust. The major players are Supernus Pharmaceuticals, Britannia Pharmaceuticals, AbbVie , Pharma Two B, Mitsubishi Tanabe Pharma Corporation, NeuroDerm and others which are currently developing drugs for the treatment of Parkinson's disease.
The market size is estimated through data analysis, statistical modeling, and expert opinions. It may consider factors such as prevalent cases, treatment costs, revenue generated, and market trends.
The increase in diagnosed prevalent cases of Parkinson's Disease and the launch of emerging therapies are attributed to be the key drivers for increasing the Parkinson's disease market.
Introducing new therapies, advancements in diagnostic techniques, and innovations in treatment approaches can significantly impact the Parkinson's disease treatment market. Market forecast reports may provide analysis and predictions regarding the potential impact of these developments.
The market forecast report may include information on the competitive landscape, profiling key market players, their product offerings, partnerships, and strategies, and helping stakeholders understand the competitive dynamics of the Parkinson's Disease market.