PUBLISHER: DelveInsight | PRODUCT CODE: 1553398
PUBLISHER: DelveInsight | PRODUCT CODE: 1553398
DelveInsight's "Axial Spondyloarthritis - Market Insights, Epidemiology and Market Forecast - 2034" report delivers an in-depth understanding of the indication axial spondyloarthritis, historical and forecasted epidemiology as well as the axial spondyloarthritis market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.
The axial spondyloarthritis market report provides real-world prescription pattern analysis, emerging drugs, market share of individual therapies, and historical and forecasted 7MM axial spondyloarthritis market size from 2020 to 2034. The report also covers current axial spondyloarthritis treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market's underlying potential.
Axial Spondyloarthritis Overview, Country-Specific Treatment Guidelines and Diagnosis
Axial Spondyloarthritis is a type of arthritis that primarily causes pain and swelling in the spine and the sacroiliac joints, which connect the bottom of the spine to the pelvis. It can also affect other joints and is a systemic disease, potentially impacting other body parts and organs. AxSpA often runs in families and can be categorized into two types: ankylosing spondylitis, or radiographic axSpA, where damage to the sacroiliac joints and spine is visible on X-rays, and non-radiographic axSpA, where damage may not be visible on X-rays but can be detected through magnetic resonance imaging (MRI). The condition typically begins between age 20 and 40 and is more common in men, although nr-axSpA may affect men and women equally.
The axial spondyloarthritis report provides an overview of axial spondyloarthritis pathophysiology, diagnostic approaches, and detailed treatment algorithm along with a real-world scenario of a patient's journey beginning from the first symptom, the time taken for diagnosis to the entire treatment process.
Further details related to country-based variations in diagnosis are provided in the report
Axial SpondyloarthritisTreatment
There is no cure for Axial Spondyloarthritis, but treatment focuses on relieving pain and stiffness in the back and other affected areas, maintaining spinal alignment, preventing joint and organ damage, preserving joint function and mobility, and improving the overall quality of life. Early and aggressive treatment is essential to prevent long-term complications and joint damage. A comprehensive treatment plan typically includes medication, non-drug therapies, healthy lifestyle habits, and, in rare cases, surgery.
The Axial Spondyloarthritis epidemiology chapter in the report provides historical as well as forecasted in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), the United Kingdom, and Japan from 2024 to 2034. The axial spondyloarthritis epidemiology is segmented with detailed insights into Total Prevalent Cases, Total Diagnosed Prevalent Cases, Gender-specific Cases, Gene-specific Cases, Age-specific Cases, Total Treated Cases of Axial Spondyloarthritis in the 7MM [2020-2034]
The drug chapter segment of the axial spondyloarthritis report encloses a detailed analysis of axial spondyloarthritis marketed drugs. It also deep dives into the axial spondyloarthritis pivotal clinical trial details, recent and expected market approvals, patent details, the latest news, and recent deals and collaborations.
Marketed Drugs
SIMPONI (golimumab): Janssen Pharmaceuticals
SIMPONI is a human IgG1? monoclonal antibody specific for human tumor necrosis factor-alpha (TNF--a) that exhibits multiple glycoforms. It was created using genetically engineered mice immunized with human TNF, resulting in an antibody with human-derived antibody variable and constant regions. It binds to both the soluble and transmembrane bioactive forms of human TNFa. This interaction prevents the binding of TNFa to its receptors, thereby inhibiting the biological activity of TNFa (a cytokine protein). This molecule is produced by a recombinant cell line cultured by continuous perfusion and is purified by a series of steps that include measures to inactivate and remove viruses.
In April 2009, the US FDA approved SIMPONI for the treatment of patients with Ankylosing Spondylitis.
XELJANZ (tofacitinib): Pfizer
XELJANZ, a film-coated immediate-release tablet, is the first and only oral JAK inhibitor approved in the European Union for five indications. It is prescribed for adults with active AS who have not responded adequately to conventional therapy and for adults with moderately to severely active RA after failure or intolerance to disease-modifying antirheumatic drugs (DMARDs). Additionally, it is used for adults with active PsA after DMARD failure or intolerance and for adults with moderately to severely active UC who have had an inadequate response, lost response, or were intolerant to conventional therapy or a biologic agent.
In December 2021, Pfizer announced that the US Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for XELJANZ/ XELJANZ XR (tofacitinib) for the treatment of adults with active Ankylosing Spondylitis who have had an inadequate response or intolerance to one or more tumor necrosis factor (TNF) blockers.
This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2024-2034, which depends on the competitive landscape, safety, and efficacy data along with order of entry. It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.
Further detailed analysis of emerging therapies drug uptake in the report...
Axial Spondyloarthritis Activities
The report provides insights into different therapeutic candidates. It also analyzes key players involved in developing targeted therapeutics.
Pipeline Development Activities
The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for axial spondyloarthritis emerging therapies.
KOL Views
To keep up with the real-world scenario in current and emerging market trends, we take opinions from Key Industry leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts were contacted for insights on the evolving treatment landscape, patient reliance on conventional therapies, patient therapy switching acceptability, and drug uptake along with challenges related to accessibility.
DelveInsight's analysts connected with 10+ KOLs to gather insights; however, interviews were conducted with 5+ KOLs in the 7MM. Centers such as Nationwide Children's Hospital, Columbus, OH, the United States, University Hospitals Dorset NHS Foundation Trust, North Shore University Health System, Evanston, Illinois, etc., were contacted. Their opinion helps understand and validate current and emerging treatment patterns of Axial Spondyloarthritis. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
Qualitative Analysis
We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of gaps in disease diagnosis, patient awareness, physician acceptability, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.
Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
In efficacy, the trial's primary and secondary outcome measures are evaluated; for instance, in event-free survival, one of the most important primary outcome measures is event-free survival and overall survival.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Access and Reimbursement
The report provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of currently used therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.