PUBLISHER: DelveInsight | PRODUCT CODE: 1442050
PUBLISHER: DelveInsight | PRODUCT CODE: 1442050
DelveInsight's "Glaucoma - Market Insights, Epidemiology and Market Forecast - 2034" report delivers an in-depth understanding of the Glaucoma, historical and forecasted epidemiology and the Glaucoma market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.
The Glaucoma market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM, Glaucoma market size from 2020 to 2034. The report also covers current Glaucoma treatment practices/algorithms and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.
Study Period: 2020-2034
Glaucoma Overview
According to the American Academy of Ophthalmology, glaucoma describes a group of conditions in which there is characteristic cupping of the optic disc with corresponding visual field defects due to retinal ganglion cell loss. It is a progressive condition and the most common cause of irreversible blindness worldwide. The two major categories of glaucoma are open-angle glaucoma (OAG) and narrow-angle glaucoma/angle-closure glaucoma (ACG). Glaucoma often does not cause noticeable symptoms in the early stages, so it is often called the "silent thief of sight." As the condition progresses, peripheral (side) vision may be affected, gradually narrowing the visual field.
Glaucoma Diagnosis
Although glaucoma is not curable, early diagnosis and adequate treatment effectively reduce or prevent further optic nerve (ON) damage. The diagnosis of glaucoma typically involves a comprehensive eye examination and several specific tests, namely, tonometry (measurement of intraocular pressure), an ophthalmoscopy (evaluation of the optic nerve for signs of damage), visual field testing (perimetry), gonioscopy (assessing the drainage angle of the eye to determine the type of glaucoma) to assess the health of the optic nerve and evaluate IOP levels.
The diagnosis of glaucoma typically involves a combination of clinical evaluation, visual field testing, optic nerve examination, and measurement of intraocular pressure (IOP). The diagnosis guidelines for glaucoma can vary to some extent based on geographical regions and medical societies, such as separate guidelines published by American Academy of Ophthalmology, European Glaucoma Society Terminology, and others.
Further details related to country-based variations are provided in the report
Glaucoma Treatment
There is no cure for glaucoma, but early treatment can often stop the damage and protect the vision. Doctors use a few different types of treatment for glaucoma, including medicines (usually eye drops), laser treatment, and surgery.
Glaucoma is treated by lowering the eye pressure (intraocular pressure), and depending on the situation, management includes prescription eye drops, oral medications, laser treatment, surgery, or a combination of any of these.
Medicines: Medications for glaucoma treatment aim to lower IOP by decreasing AH production and increasing AH outflow. Prostaglandin analogs and beta-blockers are currently the most frequently used agents.
Surgery: The most common type of surgery for glaucoma is called trabeculectomy. It involves removing part of the eye-drainage tubes to allow fluid to drain more easily.
As the market is derived using the patient-based model, the Glaucoma epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Prevalent Cases of Glaucoma, Total Diagnosed Prevalent Cases of Glaucoma, Type-specific Diagnosed Prevalent Cases of Glaucoma, Type-specific Diagnosed Prevalent Cases of Open-angle Glaucoma, Gender-specific Diagnosed Prevalent Cases of Glaucoma, and Age-specific Diagnosed Prevalent Cases of Glaucoma in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain) and the United Kingdom, and Japan, from 2020 to 2034. The total prevalent cases of Glaucoma in the 7MM comprised approximately 16,632,421 cases in 2022 and are projected to increase during the forecast period 2023-2034.
The drug chapter segment of the Glaucoma report encloses a detailed analysis of Glaucoma marketed drugs and late-stage (Phase III and Phase II) pipeline drugs. It also understands the Glaucoma clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.
Marketed Drugs
ROCKLATAN/ ROCLANDA (netarsudil/latanoprost, 0.02%/0.005%): Aerie Pharmaceuticals
Roclanda (in Europe), known as Rocklatan in the United States, is fixed-dose combination of a Rho kinase inhibitor and a prostaglandin F2a analog that reduces elevated intraocular pressure (IOP) in individuals diagnosed with open-angle glaucoma or hypertension. While it obtained approval in the US in March 2019, it gained approval in the European region in January 2021.
DURYSTA (bimatoprost SR): AbbVie Inc.
DURYSTA is an ophthalmic drug delivery system for a single intracameral administration of a biodegradable bimatoprost implant which is believed to lower IOP in humans by increasing the outflow of aqueous humor through both the trabecular meshwork (conventional) and uveoscleral routes (unconventional). It imitates the effects of prostamides, specifically prostaglandin F2a.
Note: Detailed marketed therapies assessment will be provided in the final report of Glaucoma.
Emerging Drugs
NCX-470: Nicox Ophthalmics
NCX 470 is an investigational ophthalmic treatment by Nicox Ophthalmics designed to address ocular hypertension and open-angle glaucoma. It belongs to the second-generation nitric oxide (NO) category-donating prostaglandin analogs. This therapeutic candidate is administered through the ophthalmic route, targeting the prostaglandin F2 alpha receptor and soluble guanylate cyclase to achieve its effects.
Based on a dual mechanism of action, NCX 470, a monotherapy, has the potential to be a new standard of care in reducing IOP glaucoma patients.
TRS01: Tarsier Pharma
TRS01, a lead product of Tarsier Pharma in Phase III, is a breakthrough immunomodulatory approach based on a bio-inspired new molecular platform. TRS was developed to engineer the immune system. The platform approaches inflammatory diseases from within the system. The technology can effectively treat various autoimmune and inflammatory ocular diseases.
Currently, TRS01 is being evaluated in a Phase III trial, called TRS4VISION, in patients with active noninfectious anterior uveitis and uveitic glaucoma. Uveitis glaucoma is a severe late-stage blinding condition that occurs when a patient develops glaucoma on top of uveitis
Note: Detailed emerging therapies assessment will be provided in the final report of Glaucoma.
Drug Class Insights
Management of the disease focuses on lowering intraocular pressure (IOP) with the current class of drugs, like prostaglandin analogs, beta-blockers, alpha-agonists, rho kinase inhibitors (ROCK) and carbonic anhydrase inhibitors. Prostaglandin analogs increase fluid outflow, beta-blockers reduce fluid production, alpha-adrenergic agonists decrease fluid production and increase outflow, carbonic anhydrase inhibitors reduce fluid production, rho kinase inhibitors increase fluid outflow, and cholinergic agonists increase fluid drainage.
The choice of medication depends on factors such as glaucoma severity, patient response, and potential side effects.
The primary objective of disease management is to reduce intraocular pressure (IOP), typically accomplished through the use of various drug classes such as prostaglandin analogs, beta-blockers, alpha-agonists, rho kinase inhibitors (ROCK), and carbonic anhydrase inhibitors. However, not all patients benefit from these treatments, as some may still experience optic nerve deterioration despite having normal IOP levels. In addition to pharmacological interventions, alternative measures such as incisional surgery, laser surgery, and medication are also commonly recommended.
The launch of emerging therapies, such as NCX 470 (Nicox Ophthalmics), PDP-716 (Sun Pharma Advanced Research Company Limited (SPARC)/ Visiox Pharma), and others are expected to impact the market positively.
This section focuses on the uptake rate of potential drugs expected to launch in the market during 2020-2034. For example, for PDP-716, in the US we expect the drug uptake to be Slow-medium with a probability-adjusted peak share of around 2%, and years to the peak is expected to be 8 years from the year of launch.
Further detailed analysis of emerging therapies drug uptake in the report.
Glaucoma Pipeline Development Activities
The report provides insights into different therapeutic candidates in Phase III, Phase II, and Phase I stage. It also analyzes key players involved in developing targeted therapeutics.
Pipeline Development Activities
The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Glaucoma emerging therapies.
KOL Views
To keep up with current market trends, we take KOLs and SMEs' opinions working in the domain through primary research to fill the data gaps and validate the secondary research. Industry Experts were contacted for insights on Glaucoma evolving treatment landscape, patient reliance on conventional therapies, patient's therapy switching acceptability, and drug uptake along with challenges related to accessibility, including KOL from Duke University Eye Center; Glaucoma Research Foundation; Centre Hospitalier National d'Ophtalmologie; European Board of Ophthalmology; Department of Ophthalmology, Kyushu University; and others.
Delveinsight's analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. Their opinion helps to understand and validate current and emerging therapies and treatment patterns or Glaucoma market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.
Qualitative Analysis
We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT and Conjoint Analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst's discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.
Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.
Further, the therapies' safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the route of administration, order of entry and designation, probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.
Market Access and Reimbursement
The high cost of therapies for the treatment of glaucoma is a major factor restraining the growth of the global glaucoma drug market. Because of the high cost, the economic burden is increasing, leading the patient to escape from proper treatment. In the US, between 2000 and 2020, the average adjusted reimbursement for the 22 analyzed procedures decreased by 20.5%. Reimbursement is a crucial factor that affects the drug's access to the market. Market access and reimbursement options can differ depending on regulatory status, target population size, care setting, unmet need, the magnitude of incremental benefit claims, and costs.
The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.
Market Insights
Epidemiology Insights
Current Treatment Scenario, Marketed Drugs, and Emerging Therapies