Downstream Processing Market, By Technique, By Product, By Application, By End User, By Geography

Description

The Global Downstream Processing Market is estimated to be valued at USD 26.11 Bn in 2024 and is expected to reach USD 77.10 Bn by 2031, exhibiting a compound annual growth rate (CAGR) of 16.7% from 2024 to 2031.

Figure 1. Downstream Processing Market Share (%), By Region, 2024

Downstream processing refers to the purification and recovery steps in bioprocessing undertaken after fermentation to isolate the active ingredient or product of interest from cellular biomass or fermentation broth. It involves clarification to remove cellular debris and components, concentration to separate and recover the target product by reducing volume, and final purification using chromatographic techniques. Downstream processing plays a critical role in ensuring the purity, quality, and stability of biopharmaceutical products, thereby determining their success in the market. Advances in technologies for clarification and purification such as expanded bed chromatographic separation and continuous processing have enabled higher product yields and throughput at reduced costs of goods.

Market Dynamics:

The downstream processing market growth is driven by the rapid growth of the biopharmaceutical industry, preference for biologics over small molecule drugs, and strong demand for monoclonal antibodies and vaccines. However, high costs associated with downstream purification equipment and operations acts as a restraint. Advancements in continuous manufacturing and single-use technologies provide significant opportunities for market players to develop innovative solutions for integrated and modular processes. Market leaders are focusing on partnerships and M&A activities to strengthen their portfolio of purification solutions and chromatography resins.

Key features of the study:

This report provides in-depth analysis of the global downstream processing market, and provides market size (USD Million) and compound annual growth rate (CAGR%) for the forecast period (2024-2031), considering 2023 as the base year
It elucidates potential revenue opportunities across different segments and explains attractive investment proposition matrices for this market
This study also provides key insights about market drivers, restraints, opportunities, new product launches or approval, market trends, regional outlook, and competitive strategies adopted by key players
It profiles key players in the global downstream processing market based on the following parameters - company highlights, products portfolio, key highlights, financial performance, and strategies
Key companies covered as a part of this study include GE Healthcare, Merck KGaA, Thermo Fisher Scientific Inc., 3M Company, Lonza Group AG, Eppendorf AG
Insights from this report would allow marketers and the management authorities of the companies to make informed decisions regarding their future product launches, type up-gradation, market expansion, and marketing tactics
The global downstream processing market report caters to various stakeholders in this industry including investors, suppliers, product manufacturers, distributors, new entrants, and financial analysts
Stakeholders would have ease in decision-making through various strategy matrices used in analyzing the global downstream processing market

Detailed Segmentation-

By Technique
- Purification Techniques
- Solid-Liquid Separation
- Clarification/Concentration
By Product
- Chromatography Columns and Resins
- Filters
- Evaporators
- Centrifuges
- Other Products
By Application
- Antibodies Production
- Vaccines Production
- Insulin Production
- Other Application
By End User
- Biopharmaceutical Companies
- CMOs/CDMOs
- Research Institutes
- CROs
- Others
By Region:
- North America
- Europe
- Asia Pacific
- Latin America
- Middle East
- Africa
Company Profiles:
- Merck KGaA
- Thermo Fisher Scientific Inc.
- GE Healthcare
- Sartorius Stedim Biotech S.A.
- Repligen Corporation
- Pall Corporation
- M Company
- Eppendorf AG
- Agilent Technologies, Inc.
- Waters Corporation
- Shimadzu Corporation
- Bio-Rad Laboratories, Inc.
- Avantor Performance Materials, LLC
- Tosoh Corporation
- Column Technology Inc.
- Purolite
- R. Grace & Co.
- Asahi Kasei Corporation
- Novasep Holding S.A.S
- Boehringer Ingelheim

Product Code: CMI7061

1. Research Objectives and Assumptions

Research Objectives
Assumptions
Abbreviations

2. Market Purview

Report Description
- Market Definition and Scope
Executive Summary
- Market Snapshot, By Technique
- Market Snapshot, By Product
- Market Snapshot, By Application
- Market Snapshot, By End User
- Market Snapshot, By Region
Coherent Opportunity Map (COM)

3. Market Dynamics, Regulations, and Trends Analysis

Market Dynamics
- Drivers
- Restraints
- Opportunities
Impact Analysis
Market Trends
Key Developments
Regulatory Scenario
Acquisitions and Partnerships Scenario
Funding and Investments
PEST Analysis
Porter's Analysis

4. Global Downstream Processing Market - Impact of Coronavirus (COVID-19) Pandemic

Overall Impact
Government Initiatives
COVID-19 Impact on the Market

5. Global Downstream Processing Market, By Technique, 2019 - 2031, (USD Bn)

Overview
- Market Share Analysis, 2024 and 2031 (%)
- Y-o-Y Growth Analysis, 2020 - 2031
- Segment Trends
Purification Techniques
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Solid-Liquid Separation
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Clarification/Concentration
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)

6. Global Downstream Processing Market, By Product, 2019 - 2031, (USD Bn)

Overview
- Market Share Analysis, 2024 and 2031 (%)
- Y-o-Y Growth Analysis, 2020 - 2031
- Segment Trends
Chromatography Columns and Resins
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Filters
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Evaporators
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Centrifuges
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Others
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)

7. Global Downstream Processing Market, By Application, 2019 - 2031, (USD Bn)

Overview
- Market Share Analysis, 2024 and 2031 (%)
- Y-o-Y Growth Analysis, 2020 - 2031
- Segment Trends
Antibodies Production
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Vaccines Production
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Insulin Production
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)
Other Applications
- Overview
- Market Size and Forecast, and Y-o-Y Growth, 2019-2031, (USD Bn)

8. Global Downstream Processing Market, By Region, 2019 - 2031, (USD Bn)

Introduction
- Market Share Analysis, By Region, 2024 and 2031 (%)
- Y-o-Y Growth Analysis, For Region, 2020-2031
- Regional Trends
  - North America
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 - 2031, (USD Bn)
  - U.S.
  - Canada
Latin America
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 - 2031, (USD Bn)
  - Brazil
  - Mexico
  - Argentina
  - Rest of Latin America
Europe
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 - 2031, (USD Bn)
  - U.K.
  - Germany
  - Italy
  - France
  - Spain
  - Russia
  - Rest of Europe
Asia Pacific
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 - 2031, (USD Bn)
  - China
  - India
  - Japan
  - ASEAN
  - Australia
  - South Korea
  - Rest of Asia Pacific
Middle East
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Country, 2019 - 2031, (USD Bn)
  - GCC
  - Israel
  - Rest of Middle East
  - Africa
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, By Technique, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Product, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Application, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By End User, 2019 - 2031, (USD Bn)
- Market Size and Forecast, and Y-o-Y Growth, By Country/Region, 2019 - 2031, (USD Bn)
  - North Africa
  - Central Africa
  - South Africa

9. Competitive Landscape

Company Profiles
- Merck KGaA
  - Company Highlights
  - Product Portfolio
  - Key Highlights
  - Financial Performance
  - Market Strategies
- Thermo Fisher Scientific Inc.
- GE Healthcare
- Sartorius Stedim Biotech S.A.
- Repligen Corporation
- Pall Corporation
- M Company
- Eppendorf AG
- Agilent Technologies, Inc.
- Waters Corporation
- Shimadzu Corporation
- Bio-Rad Laboratories, Inc.
- Avantor Performance Materials, LLC
- Tosoh Corporation
- Column Technology Inc.
- Purolite
- W.R. Grace & Co.
- Asahi Kasei Corporation
- Novasep Holding S.A.S
- Boehringer Ingelheim

10. Analyst Recommendations

Wheel of Fortune
Analyst View
Coherent Opportunity Map

11. References and Research Methodology

References
Research Methodology
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