PUBLISHER: Coherent Market Insights | PRODUCT CODE: 1449642
PUBLISHER: Coherent Market Insights | PRODUCT CODE: 1449642
Global blarcamesin market will be valued at US$ 822.2 Mn in 2026 and is expected to reach US$ 992.4 Mn by 2031, exhibiting a compound annual growth rate (CAGR) of 3.8% from 2026 to 2031.
Report Coverage | Report Details | ||
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Base Year: | 2023 | Market Size in 2023/2024: | US$ 822.2 Mn |
Historical Data for: | 2019 to 2023 | Forecast Period: | 2026 to 2031. |
Forecast Period 2023/2024 to 2030/2031 CAGR: | 3.80% | 2030/2031 Value Projection: | US$ 992.4 Mn |
Blarcamesine is an agonist of the intracellular sigma-1 chaperone protein. Specifically, it is a mixed ligand for sigma1/muscarinic receptors. Expressed in most tissues and located at focal contacts between mitochondria and the endoplasmic reticulum, the sigma-1 receptor forms heterodimers with many other membrane receptors and, as such, influences multiple cellular pathways and physiological processes. Blarcamesine reportedly binds the sigma-1 receptor in the high nanomolar and the muscarinic receptor in the low micromolar range. The compound has been reported to have memory-preserving and neuroprotective effects in mice treated with the muscarinic receptor antagonist scopolamine, with synthetic AB oligomer injection, or with the NMDA receptor agonist dizocilpine (Villard et al., 2011). Other studies in the AB oligomer injection model suggest that blarcamesine may block tau hyperphosphorylation and protect mitochondria.
Market Dynamics:
Increasing government approval is expected to drive the growth of the market over the forecast period. For instance, on December 19, 2023, Anavex Life Sciences, a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental disorders, announced that the Committee for Medicinal Products for Human Use (CHMP) within the European Medicines Agency (EMA) agreed that oral blarcamesine for Alzheimer's disease is eligible for submission of an application for a Union Marketing Authorization in the EU under the European Medicines Agency's centralized procedure.