The Global Exosome Market - Market Size, Forecast, Trials and Trends, 2024

TABLE OF CONTENTS

1. REPORT OVERVIEW

• 1.1. Statement of the Report
• 1.2. Target Demographic
• 1.3. Report Sources
• 1.4. Purpose of the Report
• 1.5. Executive Summary
• 1.6. Introduction

2. BIOLOGY & FUNCTIONS OF EXOSOMES: AN OVERVIEW

• 2.1. Structure of an Exosome
  • 2.1.1. Molecular Contents of Exosomes
    • 2.1.1.1. Proteins in Exosomes
    • 2.1.1.2. Lipid Contents of Exosomes
    • 2.1.1.3. Nucleic Acids in Exosomes
  • 2.1.2. Membrane and Lumen Components of Exosomes
  • 2.1.3. Classification of Exosomes by Origin
    • 2.1.3.1. Natural Exosomes
      • 2.1.3.1.1. Isolation of Natural Exosomes
    • 2.1.3.2. Modified Exosomes
      • 2.1.3.2.1. Types of Therapeutic Cargos Loaded into Exosomes
      • 2.1.3.2.2. Biomedical Applications of Engineered Exosomes
  • 2.1.4. Synthetic Exosomes
• 2.2. Differences between Cell Therapy and Gene Therapy
• 2.3. The Shift from Cell Therapy to Exosome Therapy
• 2.4. Exosomes in the Next Ten Years

3. EXOSOME ENGINEERING: A NEW TECHNOLOGY PLATFORM

• 3.1. Interior Modification
  • 3.1.1. Pre-Isolation Interior Modification Methods
  • 3.1.2. Incubation
  • 3.1.3. Gene Editing
  • 3.1.4. Post-Isolation Interior Modification Methods
• 3.2. Surface Modifications
  • 3.2.1. Surface Modification through Parent Cell
  • 3.2.2. Direct Surface Modification
  • 3.2.3. Displayed Molecules in Exosomes
• 3.3. Interior Modification
  • 3.3.1. Pre-Isolation Interior Modification
  • 3.3.2. Post-Isolation Modification Methods
• 3.4. An Exosome Showing Modified Surface and Modified Interior
  • 3.4.1. Examples of Hydrophilic Cargo Loaded into Exosome Lumen

4. SCIENTIFIC PUBLICATIONS ON EXOSOMES

• 4.1. Publication Trends of Exosome Diagnostics and Therapeutics
• 4.2. PubMed Publications on Therapeutic Exosomes by Loading Technology
• 4.3. PubMed Papers on Exosome Isolation & Purification by Technology
• 4.4. PubMed Papers on Lipid Nanoparticles and Exosomes as Drug Carriers
• 4.5. Distribution of Exosome Publications by Disease Type
• 4.6. Exosome Publications by Cancer Type

5. EXOSOME PATENTS: AN OVERVIEW

• 5.1. Exosome Patent Publications over Time
• 5.2. Exosome Patents: Therapeutic vs. Diagnostics
• 5.3. Exosome Patent Applications by Exosome Source
• 5.4. Patents/Patent Applications by Isolation/Purification Technologies
• 5.5. Patents/Patent Applications by Type of Cargo
• 5.6. Patents/Patent Applications by Cargo Loading Methods
• 5.7. Patents/Patent Applications by Therapy Area
• 5.8. Leading Assignees of Exosome Patents
  • 5.8.1. Types of Patented Isolation/Preparations Technologies by Assignees
  • 5.8.2. Types of Cargos Employed by Assignees
  • 5.8.3. Cargo Loading Methods by Assignees
  • 5.8.4. Therapy Areas by Assignees
  • 5.8.5. Assignee Categories
• 5.9. Exosome Patent Applications by Jurisdiction
• 5.10. Exosome Patent Applicants
• 5.11. Exosome Patent Inventors
• 5.12. Exosome Patent Owners
• 5.13. Legal Status of Exosome Patents

6. EXOSOMES: CLINICAL TRIAL LANDSCAPE

• 6.1. Exosome Clinical Trials by Phase of Study
• 6.2. Exosome Clinical Trials by Funder Type
• 6.3. Exosome Clinical Trials by Technology
• 6.4. Current Status of Clinical Trials using Exosomes in Treating Diseases
• 6.5. Clinical Trials using Exosomes for Diagnostic Studies
• 6.6. Major Exosome R&D Companies
• 6.7. Exosome Therapeutics in Preclinical Development

7. EXOSOME ISOLATION/PURIFICATION TECHNOLOGIES: BRIEF OVERVIEW

• 7.1. Ultracentrifugation (UC)
  • 7.1.1. Differential Ultracentrifugation
  • 7.1.2. Density Gradient Ultracentrifugation (DGU)
• 7.2. Ultrafiltration (UF)
  • 7.2.1. Tandem-Configured Ultrafiltration
  • 7.2.2. Sequential Ultrafiltration
• 7.3. Size Exclusion Chromatography (SEC)
• 7.4. Polymer Precipitation Method
• 7.5. Immunoaffinity Capture Method
• 7.6. Aptamer-Based Method
• 7.7. Microfluidic Technique

8. PROPRIETARY TECHNOLOGY PLATFORMS OF EXOSOME COMPANIES

• 8.1. Description of Select Exosome Technology Platforms
  • 8.1.1. AGLE-102
  • 8.1.2. Hybridosome
  • 8.1.3. AB126
  • 8.1.4. CAP-1002 (Deramiocel)
  • 8.1.5. REGENT
  • 8.1.6. ExoFlo
  • 8.1.7. DeliverEX
  • 8.1.8. EXOVEX
  • 8.1.9. ExoSCRT
  • 8.1.10. LEAP
  • 8.1.11. ExoDx
  • 8.1.12. EXPLOR
  • 8.1.13. Exo-Target

9. EXOSOME ENGINEERING TECHNOLOGIES: AN OVERVIEW

• 9.1. Incubation Method
• 9.2. Transfection Method
• 9.3. Sonication Method
• 9.4. Electroporation Method
• 9.5. Extrusion Method
• 9.6. Freeze/Thaw Method
• 9.7. Genetic Engineering Method

10. THERAPEUTIC APPLICATIONS OF EXOSOMES: A BRIEF OVERVIEW

• 10.1. Key Players in the Exosome Therapeutic Space
  • 10.1.1. EXO-CD24 from Nano24 (OBCTCD24)
  • 10.1.2. The Hemopurifier
    • 10.1.2.1. Hemopurifier in Cancer
    • 10.1.2.2. Hemopurifier in Infectious Diseases
  • 10.1.3. REGENT from Carmine Therapeutics
  • 10.1.4. Exosome Customization Technology from Ciola
  • 10.1.5. CAP-1002 (Deramioce) from Capricor Therapeutics
  • 10.1.6. EXPLOR from ILIAS Biologics
  • 10.1.7. AB126 from Aruna Bio
  • 10.1.8. AGLE-102 from Aegle Therapeutics
  • 10.1.9. OmniSomes from OmniSpirant Therapeutics
  • 10.1.10. EXO-101 from Exogenus Therapeutics
  • 10.1.11. Purified Exosome Product (PEP) from RION

11. DIAGNOSTIC APPLICATIONS OF EXOSOMES

• 11.1. Advantages in Diagnostic Applications
• 11.2. Major Indications Focused for Diagnosis
• 11.3. Most Common Targeted Exosome Biomarkers
  • 11.3.1. Exosomal Proteins for Diagnostic Applications
  • 11.3.2. Exosomal miRNAs as Cancer Diagnostic Agents
• 11.4. Diagnostic Exosome Research
• 11.5. Key Players in the Development of Exosome Diagnostics
  • 11.5.1. LiquidScan from BioFluidica
  • 11.5.2. ExoEnrich from ExoCan
  • 11.5.3. ExoDx Prostate Test from Exosome Diagnostics, Inc.
  • 11.5.4. TauSome Test from Exosome Sciences
  • 11.5.5. Cancer Diagnosis from Exosomics S.p.A
  • 11.5.6. Guardant360 CDx from Guardant Health
  • 11.5.7. Liver Cancer Detection study by Mursla Bio
  • 11.5.8. BDE Biomarker Assay from NanoSomiX
  • 11.5.9. ExoScreen Assay from Theoria Science

12. APPLICATIONS OF EXOSOMES IN AESTHETICS

• 12.1. Aesthetic Exosome Treatments
  • 12.1.1. Exosomes in Facial Rejuvenation
  • 12.1.2. Exosomes in Hair Restoration
  • 12.1.3. Exosomes in Scar Reduction
  • 12.1.4. Exosomes in Breast Augmentation
• 12.2. Sources of Exosomes for Aesthetic Use
• 12.3. Science behind Dermatologically Relevant Exosomes
• 12.4. Key Players & Products
• 12.5. Popular Exosome-Based Aesthetics
  • 12.5.1. AnteAGE Pro System
  • 12.5.2. ExoCR from Cartessa
  • 12.5.3. ELEVAI enfinity from ELEVAI Labs
  • 12.5.4. EXO PLUS from Exoceuticals
  • 12.5.5. Vive from Kimera Labs
  • 12.5.6. CALM Serum from RION Aesthetics
  • 12.5.7. ASCE Exosomes from ExoCoBio

13. DEALS AND FUNDRAISING IN EXOSOME SPACE

• 13.1. Venture Capital Funding for Exosome companies
  • 13.1.1. EXO Biologics
  • 13.1.2. Exogenus Therapeutics
  • 13.1.3. INEXOPLAT
  • 13.1.4. Mantra Bio
  • 13.1.5. Anjarium Biosciences
  • 13.1.6. Evox Therapeutics, Ltd.
  • 13.1.7. ILIAS Biologics
  • 13.1.8. ExoCoBio, Inc.
  • 13.1.9. Aegle Therapeutics
  • 13.1.10. Evox Therapeutics
  • 13.1.11. Evox Therapeutics
  • 13.1.12. Codiak BioSciences
  • 13.1.13. Codiak BioSciences
  • 13.1.14. Exosome Diagnostics
  • 13.1.15. Exosome Diagnostics, Inc
• 13.2. Partnership Deals in Exosome Space
  • 13.2.1. Cytiva & Rooster Bio
  • 13.2.2. SomesTech & ConvEyXO
  • 13.2.3. RoosterBio, Inc. & FUJIFILM Diosynth Biotechnologies
  • 13.2.4. Evox Therapeutics & Eli Lilly
  • 13.2.5. Exopharm & Astellas
  • 13.2.6. Univercells Technologies & RoosterBio
  • 13.2.7. AgeX Therapeutics & UCI
  • 13.2.8. VivaZome & La Trobe University
  • 13.2.9. Evotec SE & Curexsys GmbH
  • 13.2.10. Bio-Techne & QIAGEN
  • 13.2.11. InnoCan Pharma & Recipharms
  • 13.2.12. Codiak BioSciences & Sarepta
  • 13.2.13. Evox Therapeutics & Takeda
  • 13.2.14. PureTech & Roche
  • 13.2.15. Evox Therapeutics & Boehringer Ingelheim
  • 13.2.16. Sarpeta Therapeutics & Codiak Biosciences
  • 13.2.17. Navigo Proteins & MDimune
  • 13.2.18. Jazz Pharmaceuticals & Codiak BioSciences
  • 13.2.19. Exosome Diagnostics & Intezyne
  • 13.2.20. Evox Therapeutics & Boehringer Ingelheim
• 13.3. Acquisition Deals
  • 13.3.1. ExoCoBio & BENEV
  • 13.3.2. Evox Therapeutics & Codiak Biosciences' Technology
  • 13.3.3. Lonza & Exosomics
  • 13.3.4. Lonza & Codiak Biosciences
  • 13.3.5. Bio-Techne Corporation & Exosome Diagnostics
  • 13.3.6. Lonza & HansaBioMed
• 13.4. Licensing Deals
  • 13.4.1. EVerZom & Erganeo
  • 13.4.2. Elevai Labs & Yuva Biosciences
  • 13.4.3. TOPPAN & Dai Nippon Toryo
  • 13.4.4. Carnegie Mellon University (CMU) & Coya Therapeutics
  • 13.4.5. INOVIQ, Ltd. & ResearchDx, Inc.
  • 13.4.6. ATUM & Codiak BioSciences
  • 13.4.7. Johns Hopkins University & Capricor Therapeutics
  • 13.4.8. Evox Therapeutics & Eli Lily
  • 13.4.9. Codiak BioSciences & Sarepta
  • 13.4.10. VivaZome Therapeutics & University of Adelaide
  • 13.4.11. Evox Therapeutics & Takeda
  • 13.4.12. CEVEC & Evox Therapeutics
  • 13.4.13. Orgenesis & Excella Bio
  • 13.4.14. System Biosciences & QIAGEN
  • 13.4.15. PureTech Health & 3D Biotechnologies
• 13.5. IPO
  • 13.5.1. Elevai Labs
  • 13.5.2. Codiak Biosciences
  • 13.5.3. Codiak Biosciences
  • 13.5.4. Codiak BioSciences

14. EXOSOME MARKET ANALYSIS

• 14.1. Market for Exosome Therapeutics
• 14.2. The Global Market for Ready-to-Use Purified Exosomes by Type
  • 14.2.1. Market Size of Exosomes by Parent Cell Type
• 14.3. Market for Exosome Diagnostics
• 14.4. Global Exosome Technologies Market by Product Type
• 14.5. Global Exosome-Based Aesthetics (Cosmeceuticals) Market
• 14.6. The Overall Market for Exosomes
• 14.7. The Market Driver of Exosome Therapies

15. PROFILES OF EXOSOME MARKET COMPETITORS

• 15.1. 101 Bio
  • 15.1.1. PureExo Exosome Isolation Kit
• 15.2. Abbexa, Ltd.
• 15.3. AcouSort AB
  • 15.3.1. Technology: Acoustic Separation
  • 15.3.2. EIC Award
• 15.4. Aegle Therapeutics
  • 15.4.1. Research & Development
• 15.5. Aethlon Medical, Inc.
  • 15.5.1. Hemopurifier
• 15.6. Akrivis Health Care Pvt., Ltd.
• 15.7. AM BioTech
  • 15.7.1. Bio-Pulsed Technology
  • 15.7.2. ExoGiov
  • 15.7.3. LA EXO Exosome Cosmetics
• 15.8. AMS Biotechnology, Ltd. (AMSBIO)
• 15.9. AnteAGE
  • 15.9.1. At-Home Skincare Products
  • 15.9.2. At-Home Brow & Lash Products
  • 15.9.3. VRS Box (6 Pack) [$150]
  • 15.9.4. Professional Skincare Products
  • 15.9.5. Growth Factor Microneedling Products
  • 15.9.6. Stem Cell Facial Microchanneling Products
  • 15.9.7. Medical Skin Care Products
  • 15.9.8. Growth Factor Skin Treatment Products
  • 15.9.9. Growth Factor Hair Regeneration Products
• 15.10. Aposcience AG
  • 15.10.1. Wound Healing
  • 15.10.2. Myocardial Infarction
• 15.11. Aruna Bio
  • 15.11.1. AB126 (Neural Exosome)
• 15.12. BENEV Company, Inc. (ExoCoBio)
  • 15.12.1. Exosome Regenerative Complex
  • 15.12.2. Exosome Regenerative Complex +
  • 15.12.3. EXO-XOM Facial
• 15.13. BioCat GmbH
  • 15.13.1. ExoQuick Exosome Precipitation
  • 15.13.2. Exosome RNA & DNA Purification
  • 15.13.3. Exosome RNA Amplification & Profiling
  • 15.13.4. Exosome Quantification
  • 15.13.5. Exosome Antibody Array
  • 15.13.6. ExoGlow EV Labeling Kits
  • 15.13.7. Exosome Engineering
• 15.14. BioFluidica
  • 15.14.1. LiquidScan
  • 15.14.2. Exosome Isolation
• 15.15. Biological Dynamics, Inc.
  • 15.15.1. Verita Technology
  • 15.15.2. ExoVerita Pro Exosome Enrichment Platform
  • 15.15.3. Exosome Isolation & Analysis Services
• 15.16. Biorbyt, Ltd.
• 15.17. Bioscience Institute
  • 15.17.1. Bioscience Clinic Middle East
  • 15.17.2. Bioscience Genomics
  • 15.17.3. Services
    • 15.17.3.1. ExoSkin Therapy
    • 15.17.3.2. ExoHair Therapy
    • 15.17.3.3. ExoJoints Therapy
    • 15.17.3.4. ExoMale Therapy
    • 15.17.3.5. ExoFemale Therapy
    • 15.17.3.6. XOLINE Exosome Cosmetics
• 15.18. Biosynth International, Inc.
  • 15.18.1. ME Kit (Microvesicle Extraction Kit)
• 15.19. BreStem Therapeutics, Inc.
• 15.20. Capricor Therapeutics
  • 15.20.1. Portfolio
  • 15.20.2. StealthX Technology
• 15.21. Carmine Therapeutics
  • 15.21.1. REGENT Platform
• 15.22. Cellarcus Biosciences, Inc.
  • 15.22.1. vFC Vesicle Analysis Assays
  • 15.22.2. vTAG Antibodies
  • 15.22.3. Vesicles and Vesicle Assay Standards
• 15.23. Cell Care Therapeutics
  • 15.23.1. CCT-101
• 15.24. Cells for Cells
  • 15.24.1. Current Clinical Trial using Exosomes
• 15.25. Cell Guidance Systems, Ltd.
  • 15.25.1. Exosome Products
  • 15.25.2. Exo-spin Purification
  • 15.25.3. ExoLISA Technology: Exosome Detection
  • 15.25.4. Exosome Validated Antibodies
  • 15.25.5. Instant Exosomes
  • 15.25.6. NTA Size Profiling Service
• 15.26. Ciloa
  • 15.26.1. Antibodies against Undruggable Targets
  • 15.26.2. Adjuvant & Virus-Free Vaccines
  • 15.26.3. Virus-Free Therapeutic Vectors
  • 15.26.4. Technology
• 15.27. ConvEyXO
  • 15.27.1. Exo-Harvest Technology
  • 15.27.2. XomeXBio Technology
• 15.28. Craif, Inc.
  • 15.28.1. NANO IP (Nano Intelligence Platform)
• 15.29. Creative Bioarray
  • 15.29.1. Exosome Antibodies
  • 15.29.2. Exosome DNA-RNA Extraction Kits
  • 15.29.3. Exosome Isolation Tools
  • 15.29.4. Exosome Standards
  • 15.29.5. Fluorescent Exosome Standards
  • 15.29.6. Liquid Biopsy
  • 15.29.7. Exosome Research Services
• 15.30. Creative Biostructure
  • 15.30.1. Exosome Products
  • 15.30.2. Exosome Services
    • 15.30.2.1. Exosome Isolation Services
    • 15.30.2.2. Exosome Analysis Services
    • 15.30.2.3. Exosome Characterization Services
    • 15.30.2.4. Exosome Engineering Services
    • 15.30.2.5. Exosome In Vitro Functional Assay
    • 15.30.2.6. Exosome In Vitro Functional Assay
• 15.31. Creative Biolabs
  • 15.31.1. Exosome Products
  • 15.31.2. Exosome Isolation Tools
  • 15.31.3. Exosome Capture & Quantification Kits
  • 15.31.4. Exosome Antibody Products
  • 15.31.5. Exosome Standards
  • 15.31.6. Exosome Labeling Kits
  • 15.31.7. Exosomes Surface Modification Kits
  • 15.31.8. Exosome Identification Kits
  • 15.31.9. Exosome Marker cDNA Plasmid Products
  • 15.31.10. Exosome Release Modulation Reagents
  • 15.31.11. LipidSync Exosomes
  • 15.31.12. Exosome Services
• 15.32. Creative Medical Technology Holdings, Inc.
  • 15.32.1. AmnioStem Stroke Therapy
• 15.33. Creative Proteomics
  • 15.33.1. Exosome Services
• 15.34. CUSABIO Technology LLC
  • 15.34.1. Exosome Isolation Kits
• 15.35. Diadem Biotherapeutics
  • 15.35.1. Technology
• 15.36. Direct Biologics
  • 15.36.1. ExoFlo
  • 15.36.2. AmnioWrap
• 15.37. Elevai Labs, Inc.
  • 15.37.1. ELEVAI enfinity
  • 15.37.2. ELEVAI empower
  • 15.37.3. ELEVAI Root Renewal System
• 15.38. Entelexo Biotherapeutics
• 15.39. EriVan Bio
  • 15.39.1. Services
  • 15.39.2. Research Products
• 15.40. EVerZom
  • 15.40.1. EVerZom Platform
• 15.41. Evolutionary Biologics, Inc.
  • 15.41.1. EXO ELIXIR
  • 15.41.2. EVO GROW
  • 15.41.3. EVO JEL
  • 15.41.4. EXO RNA
  • 15.41.5. EVO HYBRID
  • 15.41.6. EXO PERIO
• 15.42. Evomic Science LLC
  • 15.42.1. ExoEZ Exosome Isolation Kit
• 15.43. Evox Therapeutics, Ltd.
  • 15.43.1. Gene Therapy
  • 15.43.2. Gene Editing
  • 15.43.3. RNA Therapeutics
  • 15.43.4. Precision Therapeutic Targeting
  • 15.43.5. Protein Therapeutics
  • 15.43.6. Manufacturing Exosomes
  • 15.43.7. Focus on Rare Diseases
• 15.44. EXO Biologics
  • 15.44.1. Lead Product Candidate
• 15.45. ExoCan Healthcare Technologies Pvt., Ltd.
  • 15.45.1. ExoEnrich
  • 15.45.2. ExoEngineering
  • 15.45.3. SAC-3D
  • 15.45.4. Services
    • 15.45.4.1. Multiphenotype Screen
    • 15.45.4.2. Small Molecule Screening
    • 15.45.4.3. Exo-BiDD
• 15.46. Exocel Bio
  • 15.46.1. Services
    • 15.46.1.1. Exosome Isolation via Ultracentrifugation
    • 15.46.1.2. Nanoparticle Analysis for Size Distribution and Concentration
    • 15.46.1.3. Custom Experiments with NTA
    • 15.46.1.4. Custom Growth Factors Production
  • 15.46.2. Products
    • 15.46.2.1. Exovex REVIVE
    • 15.46.2.2. Exovex RENEW
    • 15.46.2.3. Exovex REVEAL
    • 15.46.2.4. Exovex REFINE
    • 15.46.2.5. Exovex RESTORE
    • 15.46.2.6. Exovex EQUUSOME
    • 15.46.2.7. Exovex CANISOME
    • 15.46.2.8. Exovex FELISOM
• 15.47. Exogenus Therapeutics
  • 15.47.1. Exo-101
  • 15.47.2. ExoWound
• 15.48. Exokeryx, Inc.
  • 15.48.1. Demeter EVPrep
  • 15.48.2. ExoScan
• 15.49. ExoProTher Medical
• 15.50. ExoQure
  • 15.50.1. Technology
  • 15.50.2. Products
• 15.51. EXORPHIA, Inc.
  • 15.51.1. Activation Technology to produce Prime-EV
  • 15.51.2. Modification Technology to Produce Smart-EV
  • 15.51.3. INPACT-EV Technology
  • 15.51.4. EV Analysis Technology: EV-QUEST
  • 15.51.5. EXORPHIA's Product Pipeline
• 15.52. ExosomeDx (biotechne)
  • 15.52.1. ExoDx Prostate Test
  • 15.52.2. Pharma Services
  • 15.52.3. Biomarker Discovery Services
• 15.53. ExosomePlus
  • 15.53.1. MSC-Derived Exosomes
  • 15.53.2. ExoCope Technology
• 15.54. Exosome Sciences
  • 15.54.1. TauSome (Exosomal Tau) Biomarker
• 15.55. ExoStemTech Co., Ltd.
  • 15.55.1. Cartisome
  • 15.55.2. EST-T-EXO
  • 15.55.3. Hepatosome
  • 15.55.4. Hypoxisome
  • 15.55.5. Exosome Manufacturing Platform
  • 15.55.6. Protein Loading & Delivery Platform
• 15.56. ExoVectory
  • 15.56.1. Technology
  • 15.56.2. Therapeutic Areas Focused
  • 15.56.3. Exosome Immunotherapy for Cancer
  • 15.56.4. Exosome Gene Therapy
• 15.57. ExSURE Pvt. Ltd.
• 15.58. Florica Therapeutics
• 15.59. HansaBioMed Life Sciences, Ltd.
  • 15.59.1. Products
  • 15.59.2. Services
• 15.60. ILIAS Biologics, Inc.
  • 15.60.2. Cargo Loading Process
  • 15.60.3. Exo-Target: Platform Technology
• 15.61. INEXOPLAT, Inc.
• 15.62. Innocan Pharma
  • 15.62.1. Cannabidiol (CBD)-Loaded Exosomes
• 15.63. Innovex Therapeutics, SL
  • 15.63.1. Research & Development
  • 15.63.2. Vaccine against Plasmodium vivax malaria (PvRexVac)
  • 15.63.3. Vaccine against COVID-19 (ExoCoVac)
  • 15.63.4. Vaccine against PRRSV (PrrsvExoVac)
• 15.64. INOVIQ, Ltd.
  • 15.64.1. NETs Technology
  • 15.64.2. EXO-NET Pan Exosome
• 15.65. Irazu Oncology
• 15.66. Izon Science, Ltd.
  • 15.66.1. qEV Isolation
  • 15.66.2. qEV Automation
  • 15.66.3. qEV Zenco
  • 15.66.4. Robotic System for Diagnostic Development
  • 15.66.5. qEV Magnetic Concentration Kit
  • 15.66.6. Tunable Resistive Pulse Sensing (TRPS)
• 15.67. Kimera Labs, Inc.
  • 15.67.1. Vive
  • 15.67.2. Luxir & Luxir+
• 15.68. Leading Biology, Inc.
• 15.69. LifeSpan Biosciences, Inc.
• 15.70. Lonza Group, Ltd.
  • 15.70.1. Exosome Service
• 15.71. Mantra Bio
  • 15.71.1. REVEAL
  • 15.71.2. Partnering
• 15.72. Mercury Bio
  • 15.72.1. The Chimeric yEV System
• 15.73. Mercy Bioanalytics
  • 15.73.1. The Mercy Halo Test
• 15.74. Micregen, Ltd.
  • 15.74.1. Secretomix
• 15.75. Microgentas
  • 15.75.1. Products
    • 15.75.1.1. Exo TFF
    • 15.75.1.2. ExoFilter
    • 15.75.1.3. ExoCAS-2 (Exosome Clustering and Scattering)
    • 15.75.1.4. ExoPAS Advanced (Exosome Precipitation and Scattering)
    • 15.75.1.5. miRQuick (Exosomal miRNA)
    • 15.75.1.6. PIBEX System
    • 15.75.1.7. Plant Exosomes for Cosmetics
    • 15.75.1.8. Centella Asiatica Extracellular Vesicles (CICA EVs)
  • 15.75.2. Services
• 15.76. miR Scientific
  • 15.76.1. miR Sentinel
• 15.77. Mursla Bio
  • 15.77.1. Liver EV Liquid Biopsy Platform
• 15.78. MyBioSource, Inc.
• 15.79. Nano 24 (OBCDCT24)
• 15.80. NanoSomiX, Inc.
  • 15.80.1. Technology
• 15.81. Nanovex Biotechnologies
  • 15.81.1. Technology
  • 15.81.2. Synthetic Exosomes
• 15.82. NeurExo Sciences
  • 15.82.1. Research & Development Programs
• 15.83. NeuroDex, Inc.
  • 15.83.1. ExoSORT
  • 15.83.2. Lumin-EV
  • 15.83.3. Alpha-synuclein Assay
  • 15.83.4. TDP43 Assay
  • 15.83.5. Synaptic Protein Assay
  • 15.83.6. Autophagy Assay
  • 15.83.7. Biomarker Discovery Services
  • 15.83.8. LuminEV Kit
• 15.84. Norgen Biotek Corporation
  • 15.84.1. Exosome Kits
    • 15.84.1.1. Intact Exosome Purification
    • 15.84.1.2. RNA Isolation from Intact Exosomes
    • 15.84.1.3. Exosome Purification, Exosome RNA and Free-Circulating RNA Isolation
    • 15.84.1.4. RNA Isolation from Purified Intact Exosomes
    • 15.84.1.5. Exosome Depletion
    • 15.84.1.6. Exosome Labeling and Cleaning Kit
    • 15.84.1.7. Isolation Services
    • 15.84.1.8. Contract Manufacturing Services
• 15.85. Novaxomx GmbH
  • 15.85.1. Technology
• 15.86. Novus Biologicals
  • 15.86.1. Exosome Research Tools
• 15.87. NurExone Biologic, Inc.
  • 15.87.1. ExoTherapy
• 15.88. Oasis Diagnostics Corporation
  • 15.88.1. Pure.SAL
• 15.89. NX Prenatal, Inc.
  • 15.89.1. Technology
• 15.90. OmniSpirant Therapeutics
  • 15.90.1. OmniSome Therapeutic Platform
• 15.91. OncoXome, Inc.
  • 15.91.1. OncoXome's Exosomes
• 15.92. Paracrine Therapeutics Pte, Ltd.
  • 15.92.1. Science
• 15.93. QIAGEN
  • 15.93.1. exoEasy Maxi Kit
  • 15.93.2. exoRNeasy Midi Kit
  • 15.93.3. mercury LNA miRNA Focus PCR Panels
  • 15.93.4. miRCURY Exosome Serum/Plasma Kit
• 15.94. Reactive Medical Labs
• 15.95. ReNeuron
  • 15.95.1. CustomEX - A Customizable Exosome Platform
• 15.96. RION Aesthetics, Inc.
  • 15.96.1. Products
    • 15.96.1.1. INTENSE Serum
    • 15.96.1.2. DAILY Serum
    • 15.96.1.3. CALM Serum
    • 15.96.1.4. HAIR Serum
• 15.97. Rivela Diagnostics
  • 15.97.1. Technology
• 15.98. RoosterBio, Inc.
  • 15.98.1. MSC-derived Exosomes
  • 15.98.2. QuickShip Exosomes
  • 15.98.3. QuickShip MSC and Exosome Media
  • 15.98.4. XF Bioreactor MSC & EV Development Kits
  • 15.98.5. XF Bioreactor MSC & EV Scale-Up Kits
  • 15.98.6. XF Bioreactor MSC & EV Starter Kits
  • 15.98.7. RoosterCollect-EV-CC
• 15.99. ShiftBIO
  • 15.99.1. NSM Platform Technology
• 15.100. SOL Bio Corporation
  • 15.100.1. Business Model
  • 15.100.2. NeutraRelease Technology
  • 15.100.3. ExoMain
  • 15.100.4. ExoBead
• 15.101. SomesTech
  • 15.101.1. Products & Solutions
    • 15.101.1.1. ExoNP
    • 15.101.1.2. ExoLoad
    • 15.101.1.3. AI + DDS
• 15.102. Stem Cell Medicine, Ltd.
  • 15.102.1. SCM's Pipeline
• 15.103. System Biosciences
  • 15.103.1. Products
    • 15.103.1.1. Exosome Isolation Products
    • 15.103.1.2. Exosome Detection Products
    • 15.103.1.3. Exosome Quantitation Products
    • 15.103.1.4. Exosome Labeling Kit Products
    • 15.103.1.5. Exosome Biomarker Discovery Products
    • 15.103.1.6. Exosome Engineering & Design Products
  • 15.103.2. Services
• 15.104. Theoria Science, Inc.
  • 15.104.1. ExoScreen Technology
• 15.105. TheraXyte
  • 15.105.1. TAXY - A Programmable Drug Delivery System
• 15.106. Thermo Fisher Scientific
  • 15.106.1. Exosome Products for Testing & Research
• 15.107. TheraXyte Bioscience
  • 15.107.1. TAXY
• 15.108. The Tiny Cargo Company
• 15.109. TransGen Biotech, Co., Ltd.
  • 15.109.1. Products
    • 15.109.1.1. TransExo Cell Media Exosome Kit
    • 15.109.1.2. TransExo Urine Exosome Kit
    • 15.109.1.3. TransExo Serum/Plasma Exosome Kit
    • 15.109.1.4. TransExo Serum/Plasma Exosome Total RNA Extraction Kit
    • 15.109.1.5. TransExo Serum/Plasma Exosome Total miRNA Extraction Kit
• 15.110. Tymora Analytical
  • 15.110.1. Services
    • 15.110.1.1. Plasma Proteomics (PTMs)
    • 15.110.1.2. Urine Proteomics
    • 15.110.1.3. Saliva Proteomics
    • 15.110.1.4. Tissue Proteomics
• 15.111. Unicyte AG
  • 15.111.1. Technology
• 15.112. Urvogelbio Pvt, Ltd.
• 15.113. Versatope Therapeutics
  • 15.113.1. Technology
  • 15.113.2. Universal Influenza Vaccine
• 15.114. VesiCURE Therapeutics
  • 15.114.1. modEXO Platform
  • 15.114.2. dilEVery Delivery System
• 15.115. Vesigen Therapeutics, Inc.
  • 15.115.1. ARMMs
  • 15.115.2. Disease Areas of Focus
    • 15.115.2.1. Ocular
    • 15.115.2.2. Immunology
    • 15.115.2.3. Neurology
    • 15.115.2.4. Hematology
• 15.116. VivaZome Therapeutics
  • 15.116.1. VivaZome's Clinical Targets
• 15.117. ZEO ScientifiX, Inc.
  • 15.117.1. Aesthetic Exosomes
  • 15.117.2. PPX
• 15.118. Xosomix

INDEX OF FIGURE

• FIGURE 2.1: Classification of Extracellular Vesicles
• FIGURE 2.2: Exosome Formation
• FIGURE 2.3: Exosome Uptake by Target Cells
• FIGURE 2.4: Structure of an Exosome
• FIGURE 2.5: Membrane Lumen Components of Exosomes
• FIGURE 2.6: Classification of Exosomes by Origin
• FIGURE 2.7: Exosome Isolation Methods
• FIGURE 2.8: Exosomes with Loaded Therapeutics in the Lumen and Surface Display
• FIGURE 3.1: Pre-Isolation Interior Modification Methods
• FIGURE 3.2: Post-Isolation Interior Modification Methods
• FIGURE 3.3: Surface Modification through Parent Cell
• FIGURE 3.4: Direct Surface Modification
• FIGURE 3.5: Pre-Isolation Interior Modification Methods
• FIGURE 3.6: Post-Isolation Interior Modification Methods
• FIGURE 3.7: An Engineered Exosome showing Surface and Interior Modifications
• FIGURE 4.1: Number of PubMed.gov Publications, 2000-2024
• FIGURE 4.2: Publication Trends of Exosome Diagnostics and Therapeutics
• FIGURE 4.3: Number of PubMed Papers on Exosome Cargo-Loading by Technology
• FIGURE 4.4: PubMed Papers on Exosome Isolation & Purification by Technology
• FIGURE 4.5: PubMed Papers on Lipid Nanoparticles and Exosomes as Drug Carriers
• FIGURE 4.6: Distribution of Exosome Publications by Disease Type
• FIGURE 4.7: Exosome Publications by Cancer Type
• FIGURE 5.1: Exosome Patent Publications over Time, 2000-June 2024
• FIGURE 5.2: Exosome Patents: Therapeutic vs. Diagnostics
• FIGURE 5.3: Exosome Patents/Patent Applications by Exosome Sources
• FIGURE 5.4: Patents/Patent Applications by Isolation-Preparation Technologies
• FIGURE 5.5: Patents/Patent Applications by Type of Cargo
• FIGURE 5.6: Patents/Patent Applications by Cargo Loading Methods
• FIGURE 5.7: Patents/Patent Applications by Therapy Area
• FIGURE 5.8: Leading Assignees of Exosome Patents
• FIGURE 5.9: Top Five Countries with Exosome Patents
• FIGURE 6.1: Percent Share of Clinical Trials by Application
• FIGURE 7.1: Schematic of Differential Ultracentrifugation
• FIGURE 7.2: Schematic of Density Gradient Ultracentrifugation
• FIGURE 7.3: Schematic of Tandem Configured Ultrafiltration
• FIGURE 7.4: Sequential Ultrafiltration
• FIGURE 7.5: Schematic of Size Exclusion Chromatography
• FIGURE 7.6: Schematic of Polymer Precipitation Method
• FIGURE 7.7: Schematic of Immunoaffinity Capture Method
• FIGURE 7.8: Diagram of Working Principle of Microfluidic Device
• FIGURE 9.1: Schematic of Incubation Method of Drug Loading
• FIGURE 9.2: Schematic of Transfection Method
• FIGURE 9.3: Schematic Illustration of Sonication Method
• FIGURE 9.4: Schematic Illustration of the Principle of Electroporation
• FIGURE 9.5: Schematic Illustration of Drug Loading by Extrusion Method
• FIGURE 9.6: Schematic Illustration of Genetic Modification of Exosome
• FIGURE 10.1: Schematic Illustration of the Structure of EXO-CD24
• FIGURE 10.2: Aethlon's Hemopurifier
• FIGURE 10.3: Ciola's Unique in vivo Technology
• FIGURE 10.4: Schematic of EXPLOR
• FIGURE 10.5: CNS Specificity of AB126
• FIGURE 10.6: OmniSomes from OmniSpirant
• FIGURE 10.7: EXO-101 from Exogenus
• FIGURE 11.1: Great Things in Tiny Packages
• FIGURE 11.2: Major Indications Focused for Diagnosis
• FIGURE 11.3: LiquidScan from BioFluidica
• FIGURE 11.4: Exosome Isolation by ExoEnrich
• FIGURE 11.5: Features of ExoDx Prostate Test
• FIGURE 11.6: ExoScreen Assay from Theoria Science
• FIGURE 12.1: Exosomes in Facial Rejuvenation using DermaPen
• FIGURE 12.2: Exosome Therapy for Hair Restoration
• FIGURE 12.3: Exosomes in Scar Reuction
• FIGURE 12.4: AnteAGE Pro System
• FIGURE 12.5: ExoCR from Cartessa
• FIGURE 12.6: ELEVAI enfinity
• FIGURE 12.7: EXO PLUS from Exoceuticals
• FIGURE 12.8: Vive from Kimera Labs
• FIGURE 12.9: CALM Serum from RION Aesthetics
• FIGURE 12.10: ASCE Exosomes from ExoCoBio
• FIGURE 14.1: Market for the Likely-to-be Approved Exosome Therapeutics, 2029-2035
• FIGURE 14.2: Global Market for Ready-to-Use Exosomes by Type, 2023
• FIGURE 14.3: Global Exosome Therapy Market by Parent Cell Type, 2023
• FIGURE 14.4: Global Market for Exosome Diagnostics by Geography, 2023-2031
• FIGURE 14.5: Global Exosome Technologies Market by Products, 2023-2031
• FIGURE 14.6: Global Market for Exosome-based Aesthetic Products by Segment
• FIGURE 14.7: The Overall Exosome Market by Segment, 2031
• FIGURE 15.1: Aethlon's Hemopurifier
• FIGURE 15.2: qEV Zenco for Therapeutic Development
• FIGURE 15.3: Robotic System for Diagnostic Development

INDEX OF TABLES

• TABLE 2.1: Number of Molecular Contents identified in Exosomes
• TABLE 2.2: Proteins Identified in Exosomes
• TABLE 2.3: Common Lipid Contents of Exosomes
• TABLE 2.4: Nucleic Acids Present in Cancer-Derived Exosomes
• TABLE 2.5: Types of Therapeutic Cargos Loaded into Exosomes
• TABLE 2.6: Differences between Cell Therapy and Exosome Therapy
• TABLE 3.1: Hydrophobic Cargo Incorporated in Exosome Mmbrane
• TABLE 3.2: Examples of Hydrophilic Cargo Loaded into Exosome Lumen
• TABLE 5.1: Exosome Patent Applications by Jurisdiction as of June 23, 2024
• TABLE 5.2: Exosome Patent Applicants
• TABLE 5.3: Exosome Patent Inventors
• TABLE 5.4: Exosome Patent Owners
• TABLE 5.5: Legal Status of Exosome Patents as of June 22, 2024
• TABLE 6.1: Exosome Clinical Trials by Phase of Study
• TABLE 6.2: Exosome Clinical Trials by Funder Type
• TABLE 6.3: Exosome Clinical Trials by Technology
• TABLE 6.4: Current Status of Clinical Trials using Exosomes in Treating Diseases
• TABLE 6.5: Clinical Trials using Exosomes for Diagnostic Studies
• TABLE 6.6: Major Exosome R&D Companies
• TABLE 6.7: Exosome Therapeutics in Preclinical Development
• TABLE 8.1: Exosome Technology Platforms Developed by Commercial Companies
• TABLE 10.1: Key Players in Therapeutic Exosome Research
• TABLE 11.1: Most Common Targeted Exosome Biomarkers
• TABLE 11.2: Exosomal Proteins for Diagnostic Applications
• TABLE 11.3: Exosomal miRNAs as Cancer Diagnostic Agents
• TABLE 11.4: A Sample of Exosome Diagnostic Clinical Trials
• TABLE 11.5: Key Players in the Development of Exosome Diagnostics
• TABLE 12.1: Key Players in Exosome-based Aesthetics
• TABLE 13.1: Venture Capital Funding raised by Exosome Companies
• TABLE 13.2: Partnership/Collaboration Deals in Exosome Space
• TABLE 13.3: Acquisition Deals in Exosome Space
• TABLE 13.4: Licensing Deals in Exosome Space
• TABLE 13.5: Exosome Companies raising IPO Funds
• TABLE 14.1: Likely-to-be Approved Exosome Therapeutics between 2026 and 2029
• TABLE 14.2: Market for the Likely-to-be Approved Exosome Therapeutics, 2029-2035
• TABLE 14.3: Global Market for Ready-to-Use Exosomes by Type, 2023-2031
• TABLE 14.4: Global Exosome Therapy Market by Parent Cell Type, 2023-2031
• TABLE 14.5: Global Market for Exosome Diagnostics by Geography, 2023-2031
• TABLE 14.6: Global Exosome Technologies Market by Products, 2023-2031
• TABLE 14.7: Global Market for Exosome-based Aesthetic Products by Segment
• TABLE 14.8: The Overall Market for Exosomes
• TABLE 15.1: Aegle's Product Pipeline
• TABLE 15.2: Aruna Bio's Product Pipeline
• TABLE 15.3: BreStem Therapeutics' Product Pipeline
• TABLE 15.4: Capricor's Multi-Stage Pipeline
• TABLE 15.5: Entelexo's Pipeline
• TABLE 15.6: Evox Therapeutics' Product Pipeline
• TABLE 15.7: EXO Biologic's Product Pipeline
• TABLE 15.8: EXORPHIA's Product Pipeline
• TABLE 15.9: ExoStemTech's Pipeline Products
• TABLE 15.10: ILIAS' Product Pipeline
• TABLE 15.11: INOVIQ's Development Pipeline
• TABLE 15.12: NeurExo's Research & Development Programs
• TABLE 15.13: NeuroDex's Pipeline
• TABLE 15.14: ShiftBIO's Natural Drug Delivery Platform-based Programs
• TABLE 15.15: Unicyte's Pipeline