PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1515380
PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1515380
gRNA Market size was valued at USD 489.34 Million in 2023, expanding at a CAGR of 18.5% from 2024 to 2032.
gRNA, or guide RNA, is a short synthetic RNA molecule vital to the CRISPR-Cas9 gene-editing system. It comprises two parts: a scaffold sequence that binds to the Cas9 enzyme and a customizable spacer sequence that identifies the target DNA sequence. The gRNA directs the Cas9 enzyme to a specific location in the genome through complementary base pairing with the target DNA, enabling precise cutting and subsequent gene modification. This targeted approach allows for gene knockouts, insertions, or corrections, making gRNA indispensable for genetic research and therapeutic applications.
gRNA Market- Market Dynamics
Growing research and development activities in the fields of proteomics and genomics to propel market demand
gRNA is witnessing significant demand due to its pivotal role in CRISPR-based genetic engineering. With its unique capability to guide the CRISPR system to specific DNA sequences, gRNA enables precise gene editing, driving advancements in medicine, agriculture, and biotechnology. The high demand for gRNA stems from its precision, versatility, and efficiency, promising breakthroughs in treating genetic disorders, revolutionizing agricultural methods, and uncovering hidden molecular pathways. The market is witnessing significant growth in research and development (R&D) activities within genomics and proteomics. Genomics-focused R&D aims to identify and validate potential targets for therapy while gaining insights into gene functions. Throughout this process, gRNAs play a pivotal role by enabling precise gene editing through CRISPR/Cas systems. Researchers leverage gRNAs to modify target genes, facilitating the examination of their effects and expediting the identification and validation of critical targets. R&D initiatives in proteomics and genomics frequently involve large-scale investigations to elucidate gene and protein functions. gRNAs are indispensable in functional genomics research, allowing researchers to selectively deactivate or adjust specific genes, thus deepening our understanding of gene function and unraveling complex biological pathways. Consequently, this sustained demand for gRNAs is fueled by these advancements in the long term.
gRNA Market- Key Insights
As per the analysis shared by our research analyst, the global market is estimated to grow annually at a CAGR of around 18.5% over the forecast period (2024-2032)
Based on Products and Services segmentation, the product was predicted to show maximum market share in the year 2023
Based on gRNA Type segmentation, research use was the leading type in 2023
Based on Application segmentation, Genome Engineering was the leading type in 2023
Based on End User segmentation, Pharmaceutical & Biotechnology Companies were the leading type in 2023
Based on region, North America was the leading revenue generator in 2023
The Global gRNA Market is segmented based on Products and Services, gRNA Type, Application, End User, and Region.
The market is divided into two categories based on Products and Services: Products and Custom gRNA Synthesis Services. In 2023, the product segment emerged as the leader in the gRNA market size, capturing a substantial revenue share. These products are preferred due to their remarkable characteristics of precision, efficacy, and selectivity in gene editing. Alongside products, the market provides a range of services such as gRNA design, synthesis, and delivery. These services empower researchers to tailor their gene editing endeavors with customized gRNA sequences and delivery mechanisms, thereby amplifying precision and specificity throughout the process. The extensive accessibility and superior purity of these products stand as pivotal factors driving the prominence of this segment.
The market is divided into two categories based on gRNA Type: Research-Use and GMP-grade. The research-use segment accounted for the largest market share in 2023. The significant demand for research-grade gRNA stems from the multitude of research programs conducted across various research institutions. With gRNA's applications extending into clinical research, it is expected that this segment will maintain its dominance over the forecast period. Moreover, the rising adoption of CRISPR/Cas9 technology, primarily employed in gene-editing tools, adds to the heightened demand for gRNA in research endeavors.
gRNA Market- Geographical Insights
Geographically, this market is widespread in the regions of North America, Latin America, Europe, Asia Pacific, and the Middle East and Africa. These regions are further divided as per the nations bringing business. North America led the global market with the largest market share in 2023. The region's leading position in the gRNA industry can be attributed to the presence of major players and a significant rise in research and development investments by these entities to spearhead the development of innovative and advanced products. An illustrative example of this is the collaboration between Thermo Fisher and Pfizer, Inc. in May 2023. Their partnership aimed to broaden access to Next-Generation Sequencing (NGS)-based testing for cancer patients, with a specific focus on lung and breast cancer, both prevalent and serious cancers globally.
In the gRNA market, major players are implementing diverse strategies to maintain competitiveness and foster innovation. Strategic collaborations with academic institutions, biotech firms, and pharmaceutical companies facilitate technology exchange, joint research projects, and access to diverse gene-editing applications, enhancing the development of novel gRNA design tools and optimization methodologies. Acquisitions of gene-editing startups or licensing agreements for proprietary gRNA libraries enable companies to expand their product portfolios and effectively address specific market niches. Moreover, investments in CRISPR-based platforms, high-throughput screening technologies, and bioinformatics solutions bolster firms' capabilities in designing precise and efficient gRNA sequences, and accelerating gene-editing workflows for therapeutic, agricultural, and research applications. These strategic initiatives underscore companies' commitment to advancing gene-editing technologies and driving transformative changes in precision medicine, agriculture, and basic science research.
In January 2023, a team of researchers from the Netherlands, Germany, and the United States employed several CRISPR-Cas9 screens to reveal the translation of non-canonical open reading frames (ORFs) in cancer cells as a survival mechanism. This phenomenon was specifically observed in childhood medulloblastoma, which stands as the most common pediatric brain cancer.
GLOBAL gRNA MARKET KEY PLAYERS- DETAILED COMPETITIVE INSIGHTS
Illinois Tool Works Inc.
Agilent Technologies Inc.
GENEWIZ (Azenta Life Sciences)
Horizon Discovery Ltd.
Jena Bioscience GmbH
Merck KGaA
Synbio Technologies
Synthego
System Biosciences, LLC.
Takara Bio Inc.
Thermo Fisher Scientific Inc.
Others