PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1424972
PUBLISHER: AnalystView Market Insights | PRODUCT CODE: 1424972
G-Protein Coupled Receptors Market size was valued at USD 3,629 Million in 2023, expanding at a CAGR of 4.9% from 2024 to 2032.
GPCRs, known as G-protein-coupled receptors, are a highly diverse and extensive group of membrane receptors found in eukaryotes. These receptors serve as a means of communication for various types of messages, including light energy, peptides, lipids, sugars, and proteins. Their significance in the human body cannot be overstated, as they are involved in a wide range of functions. The advancements in understanding of GPCRs have had a profound impact on modern medicine, with researchers estimating that a significant portion of marketed drugs exert their effects by binding to these receptors. Among the various physiological functions and pathological processes that GPCRs are involved in, they have emerged as a prominent target for drug development. In recent times, the focus on Alzheimer's disease (AD), the most prevalent form of dementia, has intensified due to its escalating prevalence and lack of a cure.
G-Protein Coupled Receptors Market- Market Dynamics
Rise in lifestyle-related diseases such as cancer, cardiovascular and respiratory diseases are expected to propel the market growth.
The pharmaceutical industry has the potential to address the increasing burden of lifestyle-related diseases by investing in research and development that focuses on GPCRs. Efforts in drug discovery can be directed towards creating compounds that interact with GPCRs to influence disease pathways. Both researchers and pharmaceutical companies can explore new drug candidates that target specific GPCRs associated with cancer, cardiovascular diseases, and respiratory diseases. According to the World Health Organization (WHO), non-communicable diseases (NCDs), including lifestyle diseases, are responsible for the deaths of 41 million people annually, accounting for 74% of all global deaths. As of 21 March 2021, 6.6 million individuals (12.1%) were affected by either cardiovascular or respiratory conditions, with 3.5 million people (6.4%) having cardiovascular conditions and 3.7 million (6.8%) having respiratory conditions.
G-Protein Coupled Receptors Market- Key Insights
As per the analysis shared by our research analyst, the global market is estimated to grow annually at a CAGR of around 4.9% over the forecast period (2024-2032)
Based on Assay Type segmentation, cAMP Functional Assays was predicted to show maximum market share in the year 2023
Based on Product segmentation, Cell lines was the leading type in 2023
Based on Application segmentation, Cancer Research was the leading type in 2023
On the basis of region, North America was the leading revenue generator in 2023
The Global G-Protein Coupled Receptors Market is segmented on the basis of Assay Type, Product, Application, and Region.
The market is divided into seven categories based on Assay Type: cAMP Functional Assays, Calcium Functional Assays, B-Arrestin Functional Assays, Radioligand Binding & GTPγS Functional Assays, Internalization Assays, Trafficking Assays and Other Assays. The market is primarily dominated by the cAMP Functional Assays segment. cAMP, which stands for cyclic adenosine monophosphate, plays a crucial role as an intracellular signaling molecule that is closely linked to GPCRs (G-Protein Coupled Receptors). In order to comprehend the activation and modulation of GPCRs, it is imperative to conduct functional assays that measure cAMP levels.
The market is divided into five categories based on Product: Cell Lines, Detection Kits, Cell Culture Reagents and Ligands. Cell lines play a dominant role in the market, particularly in high-throughput screening campaigns for drug discovery. They are instrumental in identifying compounds that can modulate GPCR activity and have the potential to become drug candidates.
The market is divided into five categories based on Application: Cancer Research, CNS Research, Metabolic Research, Cardiovascular Research, Respiratory Research, Inflammation Research and Other Applications. The market is largely dominated by the Cancer Research segment. In order to examine the effects of receptor modulation on cancer cell behavior, researchers frequently employ cell lines that express specific GPCRs. These stable cell lines, which have modified GPCR expression, serve as valuable resources for comprehending the involvement of GPCRs in cancer.
G-Protein Coupled Receptors Market- Geographical Insights
Geographically, this market is spread across North America, Latin America, Europe, Asia Pacific, and the Middle East and Africa. These regions are further divided based on the countries involved in business activities. The market in North America is projected to have a dominant position due to the region's increased focus on drug discovery and development. North America boasts a well-established and advanced healthcare infrastructure, which includes clinical research facilities and state-of-the-art laboratories. This infrastructure facilitates the execution of clinical trials and expedites the development and testing of new drugs that target GPCRs. Over the study period, the FDA approved a total of 355 new drugs and biologics. Out of these, research and development expenditures were available for 63 products (18%), which were developed by 47 different companies. The advancements in understanding GPCR structures and functions present opportunities for the discovery of novel drugs that offer improved efficacy and specificity. Europe holds the second-largest region for market growth, primarily due to the increasing research and development activities taking place in the region.
The competitive landscape of the G-Protein Coupled Receptors (GPCRs) market is influenced by the number and quality of drugs in the development pipeline targeting these receptors. Companies that possess promising drug candidates have the potential to gain a competitive advantage. Large pharmaceutical companies often allocate significant resources to GPCR research and drug development, enabling them to conduct extensive preclinical and clinical studies on potential GPCR-targeted therapeutics. The competition within the market may vary depending on the therapeutic areas that GPCR drugs are focused on.
In April 2023, Eurofins Discovery, a leading provider of products and services for the drug discovery industry, announced its acquisition of CALIXAR, a renowned provider of high-quality membrane proteins for life science. This acquisition enhances Eurofins Discovery's capabilities in membrane protein production, particularly for highly druggable targets, and strengthens their scientific leadership in G Protein-Coupled Receptors (GPCRs) and ion channels.
GLOBAL G-PROTEIN COUPLED RECEPTORS MARKET KEY PLAYERS- DETAILED COMPETITIVE INSIGHTS
Thermo Fisher Scientific Inc.
Eurofins Scientific
QIAGEN
WuXi AppTec
Promega Corporation
Abcam plc
Merck KGaA
PerkinElmer Inc.
Enzo Biochem Inc.
BD
Others