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PUBLISHER: FirstWord Group | PRODUCT CODE: 1605937

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PUBLISHER: FirstWord Group | PRODUCT CODE: 1605937

Multiple Sclerosis - KOL Insight

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This report provides a comprehensive analysis of the current and future landscape of multiple sclerosis (MS) therapies, focusing on the decline of oral disease-modifying therapies (DMTs) and the rise of higher-efficacy treatments. It examines the market dynamics of key therapies like Zeposia, Mavenclad, and Tysabri, and explores the potential of emerging treatments such as masitinib and tolebrutinib.

Key questions answered:

  • 1. What events are impacting the uptake of oral DMTs?
  • 2. How are therapies perceived by the medical community in terms of efficacy, tolerability, and ease of administration?
  • 3. Which recently completed or ongoing clinical trials have the greatest potential to affect prescribing trends?
  • 4. What will DMTs need to show to become the treatment of choice in specific therapy lines?
  • 5. How will the use of each current and pipeline DMT change in the future in terms of line of therapy and preference?
  • 6. What will pipeline products need to show in terms of efficacy and tolerability to compete with current therapies?
  • 7. Which pipeline products are the most promising, and how will they impact current market players?
  • 8. How will the treatment landscape for MS evolve in the future for each patient segment and line of therapy?

Key brands covered in this report:

  • Mavenclad (cladribine)
  • Ocrevus (ocrelizumab)
  • masitinib
  • Gilenya (fingolimod)
  • Mayzent (siponimod)
  • Kesimpta (ofatumumab)
  • Tecfidera (dimethyl fumarate)
  • Zeposia (ozanimod)
  • Ponvory (ponesimod)
  • tolebrutinib
  • Vumerity (diroximel fumarate)
  • Tysabri (natalizumab)
  • Briumvi (ublituximab)
  • fenebrutinib
  • remibrutinib
  • Aubagio (teriflunomide)
  • vidofludimus calcium
  • frexalimab

Companies:

  • Novartis
  • Roche
  • Sanofi
  • AB Science
  • Bristol Myers Squibb
  • Biogen
  • Neuraxpharm
  • TG Therapeutics
  • Vanda
  • Merck Group
  • Immunic
  • ImmuNext
  • Juvise Pharmaceuticals

Table of Contents

Executive summary

Treatment algorithm

Research objectives

  • Marketed drugs
    • Oral disease-modifying therapies
    • Second-generation sphingosine modulators
    • Mavenclad (cladribine; Merck Group)
    • Tysabri (natalizumab; Biogen)
    • Anti-CD20 monoclonal antibodies
  • Pipeline drugs
    • Masitinib (AB Science)
    • Tolebrutinib (Sanofi)
    • Fenebrutinib (Roche)
    • Remibrutinib (Novartis)
    • Vidofludimus calcium (IMU-838; Immunic)
    • Frexalimab (Sanofi/ImmuNext)
  • Earlier-stage approaches for MS
    • Key insights summary

Appendix

  • KOL details
    • KOLs from North America
    • KOLs from Europe
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Jeroen Van Heghe

Manager - EMEA

+32-2-535-7543

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Christine Sirois

Manager - Americas

+1-860-674-8796

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